Kshirabdhi Tanaya MHN Tutor,SUM nursing college,SOA DTU ,BBSR

1. MOOD STABILIZER(Anti-Manic)
Mood stabilizers are used for the treatment of bipolar
affective disorders.
1-lithium carbonate:-
Indication:-
Prevention & treatment of manic episode of bipolar
disorder
Schizo affevtive disorder
Cyclothymia
Boderline personality disorder
Trichotillomania
Cluster headache
Alcohol dependence
Bulemia
Postpartum psychosis
Cortico-steroid induced psychosis

2. Mechanism of action:-
Norepinephrine,serotonin,dopamine,glutam
ate & GABA these neurotransmitters are
modulated or controlled by lithium.
Doses:-
900-2100 mg given in 2-3 divided doses
Normal blood lithium level:-
0.6 to 1.2meq/L
When >2meq/L it is called lithium toxicity.

3. Side effects:-
Fine hand tremor
Drowsiness
Dizziness
Headache
Dry mouth
Hypotension
Arrhythmias
Polyuria
Dehydration
Weight gain

4. Management for lithium toxicity:-
•Stop the drug
•Gastric lavage
•Dialysis
•I.V infusion

5. 2-Valproic acid(sodium valproate)
Indications:-
Manic episodes
Schizoaffective disorder
seizures
Migraine prophylaxis
Bulimia nervosa,OCD,PTSD
Dose:-
50-150 mcg/ml or 60 mg/kg/day orally

6. Side effects:-
Nausea
Vomiting
Drowsyness
Dizziness
Blood dyskariasis
Prolonged bleeding time
Risk of suicide

7. 3-Carbamazepine:-
It is a anti-convulsant drugs which is also used in mood
stabilzing.
Indications:-
seizures
Bipolar
Acute depression
Persistent schizophrenia
Mgt of alcohol withdrawal
Psychosis with Epilepsy
Trigeminal neuralgia
Boaderline personality disorder
Dose:-
6-12mcg/ml

8. SIDE EFFECTS:-
•Drowsiness
•Confusion
•Headache
•Ataxia
•Hypertension
•Dry mouth
•Nausea ,vomiting
•Abdominal pain
•Oliguria
•Bone marrow depression.