1. Name: Kennellen Rose S. Guiao Section: AB
Blood Group
System
Symbol
ISBT
Number
Chromosomal
Location
Antibodie
s
Antibody Class
Reaction
Temperature
Antigens
Clinical
Significance/Pathologic
Condition
ABO ABO 001
Chromosome
9q34.2
Anti-A
Anti-B
IgG and IgM
(predominantly)
Room temperature
(20°C to 24°C) or
below and
efficiently activate
complement at
37°C.
A, B, H
Alterred in some
hematologic disorders,
leukemia
Lewis LE 007
Chromosome
19p13.3
Anti-Lea
Anti-Leb IgM
Generally react
best at
temperatures
below 37°C.
Lea
, Leb
Le(ab), Le(bH),
ALe(b), BLe(b),
Le(x), Le(y)
Peptic ulcer
Stomach cancer
Breast cancer
Gastric cancer
Inflammatory response
to arthritic disease
colorectal cancer
Lung cancer
Risk for graft rejection
regression of anti tumor
function
MNS MNS 002
Chromosome
4q31.21
Anti-M
Anti-N
Anti-S
Anti-s
IgG and IgM
Anti-M: react
below 37°C
Anti-N: cold-
reactive IgM or IgG
saline agglutinin
Anti-S and Anti-s:
IgG, reactive a 37°C
M, N, S, s
Transfusion reactions
Hemolytic Disease of the
Fetus and Newborn
P1PK
P1PK
003
Chromosome
22q11.2–qter
Anti-P
Anti-P1
Anti-P1
k
Anti-P2
k
IgM 37°C P, P1, Pk
Hydatid disease
Fascioliasis, Clonorchis
sinensis and
Opisthorchis viverrini
infections
Biliary cirrhosis
AIHA
2. Rh RH 004
Chromosome
1p36.11
Anti-D
Anti-C
Anti-e
Anti-c
IgG 37°C D, C, E, c, e
Increased permeability
to cations
Lutheran LU 005
Chromosome
19q13.3
Anti-Lua
Anti-Lub
Anti-Lu3
IgM, IgG and IgA 37°C LU1, LU2, LU3
Lupus erythematosus
Shortened survival of
transfused cells
Post-transfusion
jaundice
Kell KEL 006
Chromosome
7q34
Anti-K
Anti-k
Anti-Kpa
Anti-Kpb
Anti-Jsb
Anti-Jsa
IgG and IgM
(rare)
37°C and
sometimes below
K, k
Kp(a), Kp(b)
Js(a), Js(b)
Severe hemolytic
diseases of newborn
Muscle and nerve
disorders
Areflexia
Elevated creatinine
phosphokinase
Duffy FY 008
Chromosome
1q23.2
Anti-Fya
Anti-Fyb
Anti-Fyx
Anti-Fy3
Anti-fy5
IgG and
IgM (rare)
37°C and
sometimes below
Fya
, Fyb
, Fy3
Hemolytic Transfusion
Reaction
Hemolytic Disease of the
Fetus and Newborn
Kidd JK 009
Chromosome
18q12.3
Anti-Jka
Anti-Jkb
IgG and IgM
(rare)
37°C and
sometimes below
Jka
and Jkb
Hemolytic Transfusion
Reaction
Hemolytic Disease of the
Fetus and Newborn
Diego DI 010
Chromosome
17q21.31
Anti-Dia
,
Anti-Dib
Anti-Wra
IgG or IgM
More active at
room temp. (25°C
and 37°C) than at
cold temp. (4°C and
18°C)
Dia
, Dib
, Wra
,
Wrb
Hemolytic Transfusion
Reaction and Hemolytic
Disease of the Fetus and
Newborn
Yt YT 011
Chromosome
7q22.1
Anti-Yta
Anti-Ytb IgG 37°C Yta
and Ytb Delayed Hemolytic
Transfusion Reaction
Xg XG 012 Xp22.33 Anti-Xga
IgG 37°C Xga
, CD99
Ichthyosis
Ocular albinism
Elevated CD99 (found in
Ewing sarcoma,
neurectodermal tumors,
lymphoma, and acute
lymphophatic leukemia)
3. Scianna SC 013
Chromosome
1p34.2
Anti-Sc1
Anti-Sc2
Anti-Sc3
Rd
IgG 37°C
Sc1, Sc2, Sc3 &
Rd (Radin)
Mild Hemolytic
Transfusion Reaction
Hemolytic Disease of the
Fetus and Newborn
Dombrock Do 014
Chromosome
12p12.3
Anti-Doa
Anti-Dob
Anti-Gya
Anti-Hy
Anti-Joa
IgG 37°C
Doa
, Dob
, Gya
,
Hy, Joa
Acute to delayed HTRs
PNH
Deficient in GPI-
anchored glycoprotein
Colton CO 015
Chromosome
7p14.3
Anti-Coa
Anti-Cob
Anti-Co3
Anti-Co4
IgG 37°C Coa
, Cob
, Co3
Acute to delayed
Hemolytic Transfusion
Reaction
Mild and Severe
Hemolytic Disease of the
Fetus and Newborn
Landsteiner-
Wiener
LW 016
Chromosome
19p13.2
Anti-LWa
Anti-
LWab
IgG 37°C LWa
, LWab
Hodgkin's disease
Leukemia and sarcoma
Lymphoma
Leukemia
Chido/Rogers CH/RG 017
Chromosome
6p21.3
Anti-Ch
Anti-Rg
IgG 37°C
Ch1, Ch2, Ch3,
Rg1 and Rg2
Graves' disease
SLE
Rheumatoid arthritis
H H 018
Chromosome
19q13.33
Anti-H IgM Below 37°C H
Acute Hemolytic
Transfusion Reaction
Hemolytic Disease of the
Fetus and Newborn
Kx XK 019 Xp21.1 Anti-KXA IgG 37°C Kx
McLeod phenotype (CNS
abnormalities, muscle
weakness,
cardiomyopathy)
Gerbich GE 020
Chromosome
2q14.3
Anti-Ge2
Anti-Ge3
Anti-Ge4
IgG and IgM
Room temperature
and below 37°C
Ge2, Ge3, Ge4
Delayed Transfusion
Reactions
Cromer CROM 021
Chromosome
1q32.2
Anti-Cra IgG 37°C Cra
Mild Hemolytic
Transfusion Reaction
Knops KN 022
Chromosome
1q32.2
Anti-Kna
Anti-Knb
Kna
, Knb
Indian IN 023
Chromosome
11p13
Anti-Ina
Anti-Inb
IgG 37°C Ina
, Inb
Hemolytic Transfusion
Reaction
4. Ok OK 024
Chromosome
19p13.3
Anti-Oka
IgG Oka
Has been implicated in
the accelerated
destruction of
transfused incompatible
red cells but no reports
of HDFN (maybe
because of its rare
presence)
Raph RAPH 025
Chromosome
11p15.5
Anti-
MER2
MER2
Hemolytic Transfusion
Reactions
John Milton
Hagen
JMH 026
Chromosome
15q24.1
Anti-JMH IgG 37°C JMH
Autoimmune RBC
Destruction
I I 027
Chromosome
6p24.2
Anti-I
Anti-i
IgM
4°C, 30°C to 32°C,
or below 37°C
I, i
Acute leukemia
HEMPAS
Raynaud's phenomenon
Sideroblastic anemia
Mononucleosis
Thalassemia
Globoside GLOB 028
Chromosome
3q26.1
Anti-P IgM and IgG
Room
temperature/
reacts at 37°C
P
Lysosomal Storage
Disorders
Aplastic Anemia
Gill GIL 029
Chromosome
9p13.3
Anti-GIL IgG 37°C GIL
Hemolytic Transfusion
Reactions
Rh-associated
glycoprotein
RHAG 030
Chromosome
6p21-qter
Anti-
RHAG1
Anti-
RHAG2
IgG 37°C
RHAG1,
RHAG2,
RHAG3,
RHAG4
Hemolytic Disease of the
Fetus and Newborn
