BPSMV, South Campus , DPER ,bhainswal Kalan , Sonipat Corticosteroids (Pharmacology)

2. • Corticosteroids are a class of steroid hormones that are
produced in the adrenal cortex.
• Corticosteroids are involved in a wide range of physiologic
system such as
 Stress response
 Immune response
 Regulation of inflammation
 Carbohydrate metabolism
 Protein catabolism
 Blood electrolytes level, and
 behaviour

6. Adrenal Gland
Medulla Cortex
Epinephrine Z. fasciculata
Z.glomerulosa Z.reticularis
Glucocorticoids
Mineralocorticoids Androgens

7. Deoxycorticosterone Acetate (DOCA)
Fludrocortisone
Aldosterone

10. cell membrane
Nucleus
Cytoplasmic
Receptor
Protein
Binding with
DNA
Transcription
of m-RNA
Corticosteroids
Steroid –
Receptor
Complex
New
Protein
Synthesis

11. Stress
Neural Input
Hypothalamus
Anterior Pituitary
Corticotropes
CRH release
CRH Synthesis

12. ACTH release
Adrenal Cortex
Glucocorticoids
Mineralocorticoids
Androgens