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Common Wisdom in
Eye Care
Science or Myth?
Dwight Thibodeaux, OD
Angle closure and normal IOP
• 60 year old female, pain, nausea and blur OD
over weekend after dilated eye exam on
previous Friday
• 2+ NSC OU
• Pupil fixed
• LASIK OU x 10 yrs
• Grade 0 angle
• 3+ corneal edema
• IOP 13 OD, 14 OS
• DX? Mgmt?
PISK
Pressure-induced
Intra-lamellar Stromal Keratitis
Diamox
+/-Compazine
Combigan q2min
Pilo 2% in 10 min,
then qid until PI
Glaucoma and ocular perfusion
OHTS - Incr. risk for long term progression
with greater fluctuations in mean ocular
perfusion pressure
• Diastolic OPP below 50 mmHg = high risk
• Treatment with HT meds and nocturnal
systemic hypotension are risk factors
Ocular Perfusion Pressure
• Diastolic Ocular Perfusion Pressure = DBP – IOP
• BP 110/70 IOP 25
• DOPP = 70-25 = 45
• DOPP < 50 high risk of progression
Blue Mountains Eye Study
• Ophthalmology Jan 2013
• 77% greater risk of developing glaucoma
within 10 years for those with narrowed
retinal arterioles
Ocular Perfusion Pressure
• OPP only an estimate using brachial BP
• Can have good OPP and still show progression
• Recently, low CSF pressure and LTG linked
Rev. of Ophth. 2011
• CSF-P and trans-laminar pressure gradient not
easily managed or measured
Biomechanical
Factors - Collagen
• IOP related connective tissue
stress within the nerve head
based on indiv. anatomy
• Compression, deformation
of lamina cribosa
• Restricted axoplasmic flow
and GC axonal damage
• Cupping is not just a sign
Corneal Hysteresis - Collagen
• Condon, Weinreb, Sullivan-
Mee, others – lower CH
increased VF loss/prog.
• Glaucoma risk factor
• Reichert ORA $14,500
• True IOP’s, CH measure
• Not yet standard of care
Neuroprotection
• Low-pressure Glaucoma Treatment Study
• A2 selective agonist vs B-blocker
• 0.2% brimonidine vs 0.5% timolol
• No significant IOP or VF differences for up
to 24 months
• After 24 months, still same IOP’s, but
better VF’s with brimonidine group
Myth: Pachymetry allows for
adjusted IOP readings
• Too many biomechanical variables
involved to assign a specific value
• Nonlinear relationship between CCT & IOP
• Best to simply use low CCT (<500) as a
biomarker/structural risk factor
Common Practice: OCT’s and
VF’s are each done yearly for
glaucoma patients
• Should give greater weight to structural tests
(OCT) early, and functional tests (VF) later
Early - OCT GCC and possibly Matrix FDT
Moderate - OCT and SITA STD 30-2 VF
Severe - 10-2 VF
Myth –Proper treatment stops
glaucoma progression
Glaucoma progression
Common Practice:
Monocular trials
Now mostly an abandoned practice
Long established crossover effect of beta blockers
Substantial PA fellow eye effects -- ARVO 2011
IOP variations differ eye to eye and day to day
Better to get multiple pre and post treatment IOP
measurements on different days and times
• ARVO 2011
• Peaks and valleys
different day to day
• Single day serial
tonometry not clinically
relevant other than
finding mean or peak
daytime IOP’s
Myth: Single-day serial
tonometry characterizes future
IOP readings
• OHTS – Single target IOP or % often too
aggressive. Target range a better option
• Thicker corneas responded less well, but
were lower risk
• Use BP and supine IOP as guides in LTG
• No easy way to measure nocturnal IOP
Common practice: A target IOP
Overnight IOP Monitor
Sensimed Triggerfish
IOP, pach, gonio, VF and
S/D photos are still the
standard of care in glaucoma
SD-OCT is now becoming the standard for
early glaucoma diagnosis. VF alone will
under-diagnose
Ophthalmology 2012 - disc margin and C/D
estimates wrong in clinical exams and
photos compared to OCT
Evolving Standard of Care
Weinreb, UCSD
OCT-measured ganglion cell loss is first optic
nerve-related glaucoma finding
Sullivan-Mee, Aug. 2012 Optometry Times
OCT GCC best measure of RNFL in high
myopes and tilted discs. More repeatable,
better in assessing GC health than PP NFL
Is cost of instrumentation limiting scope?
GCC – NFL, GCL and IPL
Depends on size, location, retinal layer
Small, disc margin NFL (flame) heme
2/3rds inferotemporal, NTG > POAG?
DDX -- PVD, diabetes, HT
Myth – All hemorrhages of the
disc signify glaucoma
progression
Disc Hemorrhage
Myth – Timolol is “old school”
• Side effects/contraindications overblown-
Melton and Thomas
• 15-20% IOP reduction at qd AM (Istalol)
• Great adjunct to PA’s, few allergic rxns.
• .25% for whites, .5% for the the more pigmented
• Very inexpensive in generic form
• GFS not needed - no better, more expensive
Myth: Alternative tx for
glaucoma are bogus
Mirtogenol - Clinical Ophthalmology, 2010
wild bilberry + pine bark extract
80 mg cap po 1/day = Lumigan qhs,
Takes 24 wks for full effect, also additive to topicals
Exercise – Johns Hopkins, 20% IOP reduction after 4 mo.
Punctal Occlusion w/plugs 2011 study - 2 mm Hg red.
Statins reduce incidence of glaucoma by 7%
Myth: Every new glaucoma
patient should be put on drops
• Consider age, health status, quality of life,
compliance and cost
• European standard of care is different - SLT first?
• Cataract sx. red. IOP by 20% in 40% of pts - OHTS
• W/iStent 68%
• Ab interno
• No bleb
• FDA approved
iStent
Trabecular Micro-bypass Stent
MIGS – Minimally Invasive
Glaucoma Surgery -ab interno
• iStent, others – 1 or more, w or w/o
cat. sx. Eliminates one topical med
• CyPass, others – supraciliary
microstents - 3mm incision
• Trabectome – RF surgical ablation of
2-4 clock hrs of trabecular meshwork
and Schlemm’s canal
Supraciliary microstents
increase uveoscleral outflow
Trabectome
MIGS – ab externo
• Canaloplasty – enlarges Schlemm’s canal
by catheter dilation and suture placement
• Ex-PRESS glaucoma filtration device
(Alcon) Placed under lamellar scleral flap
and into ant. chamber – bleb drainage,
standardizes outflow level compared to
standard trabeculectomy
Emerging alternate drug
delivery system in glaucoma
• Punctal plug - latanoprost time release
• At 4 wks 6 mmHg reduction, lasts 2 mo.
• Mean IOP decrease of 24.3%
• Adverse effect – epiphora
• Stage 2 FDA trials
• Well known iris and periocular pigment
changes, iris cysts and contraindications
for iritis and CME -- but what is this?
Prostaglandin Analogs
PAP – Prostaglandin Associated
Periorbitopathy
• Upper lid ptosis
• Fat atrophy
• Involution of
dermatochalasis
• Deepening lid sulcus
• Mild enophthalmos
• Inferior scleral show
• Prominent lid vessels
2013 CPT changes
• No additional codes for optometry in CPT, but NM
added new surgical codes:
68040 expression conj. follicles
68530 removal FB from lacrimal passages
68810 probing naso-lacrimal duct
• Two deleted codes- tonography
w/ and w/o water provocation
No ICD-9 changes, 10/1/14 ICD-10
Cigna and Lovelace
discrimination - status report
• OD’s forced to use VSP PEC for Lovelace
Salud medical visits
• OD’s forced to be panel providers for
vision plan to be on Cigna medical panel
• Meeting with Insurance Superintendent
after legislative session
2014
• NM to have Health Insurance Exchange
ready for enrollment by October 2013
• 25% of NM population on Medicaid
• 340,000 children, funded 70% of births
• 170,000 more adults expected to be on
Medicaid by 1st Qtr. 2014 - ACA
• Pediatric benefit includes annual
comprehensive eye exam vs screening
• Embedded vision plans likely primary 
SGR and IPAB
No fix for SGR soon, last cut of 5.4% in 2002
Independent Payment Advisory Board
(IPAB) established by ACA begins in 2014
Will recommend cuts, concentrating on
practitioners, based on variation from
targeted growth rate
Rulings can only be reversed by 2/3rds vote
of Congress
Medicare – Multiple
Procedure Payment
Reductions
• Started this January 1 this year for TC of VF, OCT,
photos, ultrasound, topography
• Reduced payments when multiple services are
furnished on the same day
• Most expensive service paid in full (PC and TC)
• TC of all other listed procedures paid at 50% of
fee schedule
• Claim adjustment code 59 on remittance advice
Other Third
Party Woes
• Medicare Zone Program Integrity
Contractors (ZPIC’s) and Recovery Audit
Contractors (REC’s) paid on % of amount
recovered. Using statistical sampling,
patient leads, etc.
• Unannounced visits, ruthless, $6 billon
recovered in 2012. Expanding to our zone
and moving to docs vs hospitals/facilities
EMR audit risk
• Auto-fill history for repeat patient visits vs
information entered at time of service
• Interpretation and Report poorly designed
in some software – not separate enough
from rest of chart - need orders for tests
• Complete I/R on day of service
Major Medical
Embedded
Vision Plans
• Typically low paying
• Monitor for discrimination - OD vs OMD
• Watch chair costs vs reimbursement
• Especially bad payments in optical goods
• AOA interactive calculator aoa.org/x9619

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Eyecare Myths

  • 1. Common Wisdom in Eye Care Science or Myth? Dwight Thibodeaux, OD
  • 2. Angle closure and normal IOP • 60 year old female, pain, nausea and blur OD over weekend after dilated eye exam on previous Friday • 2+ NSC OU • Pupil fixed • LASIK OU x 10 yrs • Grade 0 angle • 3+ corneal edema • IOP 13 OD, 14 OS • DX? Mgmt?
  • 4. Glaucoma and ocular perfusion OHTS - Incr. risk for long term progression with greater fluctuations in mean ocular perfusion pressure • Diastolic OPP below 50 mmHg = high risk • Treatment with HT meds and nocturnal systemic hypotension are risk factors
  • 5. Ocular Perfusion Pressure • Diastolic Ocular Perfusion Pressure = DBP – IOP • BP 110/70 IOP 25 • DOPP = 70-25 = 45 • DOPP < 50 high risk of progression
  • 6. Blue Mountains Eye Study • Ophthalmology Jan 2013 • 77% greater risk of developing glaucoma within 10 years for those with narrowed retinal arterioles
  • 7. Ocular Perfusion Pressure • OPP only an estimate using brachial BP • Can have good OPP and still show progression • Recently, low CSF pressure and LTG linked Rev. of Ophth. 2011 • CSF-P and trans-laminar pressure gradient not easily managed or measured
  • 8. Biomechanical Factors - Collagen • IOP related connective tissue stress within the nerve head based on indiv. anatomy • Compression, deformation of lamina cribosa • Restricted axoplasmic flow and GC axonal damage • Cupping is not just a sign
  • 9. Corneal Hysteresis - Collagen • Condon, Weinreb, Sullivan- Mee, others – lower CH increased VF loss/prog. • Glaucoma risk factor • Reichert ORA $14,500 • True IOP’s, CH measure • Not yet standard of care
  • 10. Neuroprotection • Low-pressure Glaucoma Treatment Study • A2 selective agonist vs B-blocker • 0.2% brimonidine vs 0.5% timolol • No significant IOP or VF differences for up to 24 months • After 24 months, still same IOP’s, but better VF’s with brimonidine group
  • 11. Myth: Pachymetry allows for adjusted IOP readings • Too many biomechanical variables involved to assign a specific value • Nonlinear relationship between CCT & IOP • Best to simply use low CCT (<500) as a biomarker/structural risk factor
  • 12. Common Practice: OCT’s and VF’s are each done yearly for glaucoma patients • Should give greater weight to structural tests (OCT) early, and functional tests (VF) later Early - OCT GCC and possibly Matrix FDT Moderate - OCT and SITA STD 30-2 VF Severe - 10-2 VF
  • 13.
  • 14. Myth –Proper treatment stops glaucoma progression
  • 16. Common Practice: Monocular trials Now mostly an abandoned practice Long established crossover effect of beta blockers Substantial PA fellow eye effects -- ARVO 2011 IOP variations differ eye to eye and day to day Better to get multiple pre and post treatment IOP measurements on different days and times
  • 17. • ARVO 2011 • Peaks and valleys different day to day • Single day serial tonometry not clinically relevant other than finding mean or peak daytime IOP’s Myth: Single-day serial tonometry characterizes future IOP readings
  • 18. • OHTS – Single target IOP or % often too aggressive. Target range a better option • Thicker corneas responded less well, but were lower risk • Use BP and supine IOP as guides in LTG • No easy way to measure nocturnal IOP Common practice: A target IOP
  • 20. IOP, pach, gonio, VF and S/D photos are still the standard of care in glaucoma SD-OCT is now becoming the standard for early glaucoma diagnosis. VF alone will under-diagnose Ophthalmology 2012 - disc margin and C/D estimates wrong in clinical exams and photos compared to OCT
  • 21. Evolving Standard of Care Weinreb, UCSD OCT-measured ganglion cell loss is first optic nerve-related glaucoma finding Sullivan-Mee, Aug. 2012 Optometry Times OCT GCC best measure of RNFL in high myopes and tilted discs. More repeatable, better in assessing GC health than PP NFL Is cost of instrumentation limiting scope?
  • 22. GCC – NFL, GCL and IPL
  • 23. Depends on size, location, retinal layer Small, disc margin NFL (flame) heme 2/3rds inferotemporal, NTG > POAG? DDX -- PVD, diabetes, HT Myth – All hemorrhages of the disc signify glaucoma progression
  • 25. Myth – Timolol is “old school” • Side effects/contraindications overblown- Melton and Thomas • 15-20% IOP reduction at qd AM (Istalol) • Great adjunct to PA’s, few allergic rxns. • .25% for whites, .5% for the the more pigmented • Very inexpensive in generic form • GFS not needed - no better, more expensive
  • 26. Myth: Alternative tx for glaucoma are bogus Mirtogenol - Clinical Ophthalmology, 2010 wild bilberry + pine bark extract 80 mg cap po 1/day = Lumigan qhs, Takes 24 wks for full effect, also additive to topicals Exercise – Johns Hopkins, 20% IOP reduction after 4 mo. Punctal Occlusion w/plugs 2011 study - 2 mm Hg red. Statins reduce incidence of glaucoma by 7%
  • 27. Myth: Every new glaucoma patient should be put on drops • Consider age, health status, quality of life, compliance and cost • European standard of care is different - SLT first? • Cataract sx. red. IOP by 20% in 40% of pts - OHTS • W/iStent 68% • Ab interno • No bleb • FDA approved
  • 29. MIGS – Minimally Invasive Glaucoma Surgery -ab interno • iStent, others – 1 or more, w or w/o cat. sx. Eliminates one topical med • CyPass, others – supraciliary microstents - 3mm incision • Trabectome – RF surgical ablation of 2-4 clock hrs of trabecular meshwork and Schlemm’s canal
  • 32. MIGS – ab externo • Canaloplasty – enlarges Schlemm’s canal by catheter dilation and suture placement • Ex-PRESS glaucoma filtration device (Alcon) Placed under lamellar scleral flap and into ant. chamber – bleb drainage, standardizes outflow level compared to standard trabeculectomy
  • 33. Emerging alternate drug delivery system in glaucoma • Punctal plug - latanoprost time release • At 4 wks 6 mmHg reduction, lasts 2 mo. • Mean IOP decrease of 24.3% • Adverse effect – epiphora • Stage 2 FDA trials
  • 34. • Well known iris and periocular pigment changes, iris cysts and contraindications for iritis and CME -- but what is this? Prostaglandin Analogs
  • 35. PAP – Prostaglandin Associated Periorbitopathy • Upper lid ptosis • Fat atrophy • Involution of dermatochalasis • Deepening lid sulcus • Mild enophthalmos • Inferior scleral show • Prominent lid vessels
  • 36. 2013 CPT changes • No additional codes for optometry in CPT, but NM added new surgical codes: 68040 expression conj. follicles 68530 removal FB from lacrimal passages 68810 probing naso-lacrimal duct • Two deleted codes- tonography w/ and w/o water provocation No ICD-9 changes, 10/1/14 ICD-10
  • 37. Cigna and Lovelace discrimination - status report • OD’s forced to use VSP PEC for Lovelace Salud medical visits • OD’s forced to be panel providers for vision plan to be on Cigna medical panel • Meeting with Insurance Superintendent after legislative session
  • 38. 2014 • NM to have Health Insurance Exchange ready for enrollment by October 2013 • 25% of NM population on Medicaid • 340,000 children, funded 70% of births • 170,000 more adults expected to be on Medicaid by 1st Qtr. 2014 - ACA • Pediatric benefit includes annual comprehensive eye exam vs screening • Embedded vision plans likely primary 
  • 39. SGR and IPAB No fix for SGR soon, last cut of 5.4% in 2002 Independent Payment Advisory Board (IPAB) established by ACA begins in 2014 Will recommend cuts, concentrating on practitioners, based on variation from targeted growth rate Rulings can only be reversed by 2/3rds vote of Congress
  • 40. Medicare – Multiple Procedure Payment Reductions • Started this January 1 this year for TC of VF, OCT, photos, ultrasound, topography • Reduced payments when multiple services are furnished on the same day • Most expensive service paid in full (PC and TC) • TC of all other listed procedures paid at 50% of fee schedule • Claim adjustment code 59 on remittance advice
  • 41. Other Third Party Woes • Medicare Zone Program Integrity Contractors (ZPIC’s) and Recovery Audit Contractors (REC’s) paid on % of amount recovered. Using statistical sampling, patient leads, etc. • Unannounced visits, ruthless, $6 billon recovered in 2012. Expanding to our zone and moving to docs vs hospitals/facilities
  • 42. EMR audit risk • Auto-fill history for repeat patient visits vs information entered at time of service • Interpretation and Report poorly designed in some software – not separate enough from rest of chart - need orders for tests • Complete I/R on day of service
  • 43. Major Medical Embedded Vision Plans • Typically low paying • Monitor for discrimination - OD vs OMD • Watch chair costs vs reimbursement • Especially bad payments in optical goods • AOA interactive calculator aoa.org/x9619