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TMJ secrets
Islam Kassem,BDS,MSc,MFDS RCS Ed,MOMS RCPS Glasg,FFD RCSI

Consultant Oral & Maxillofacial Surgeon
Islam Kassem
• BDS Alexandria Dental school 2002
• MSc Oral & Maxillofacial surgery 2008
• MFDS RCS Ed 2005
• MOMS RCPS Glasg 2009
• FFD RCSI OS OM 2011
• AO-CMF Fellowship 2012
• American Aesthetic fellowship diploma 2013
• Implant Diploma Napoli university 2014
• Laser Diploma ALD 2015
• Oral & Maxillofacial Surgeon
Declaration

• There is no conflict of interest in this
Course .
• I have no monetary benefit from this
Course.
• No implied sponsorship by any company to
the speaker 
• all photographed patients were treated by
the speaker and consented for
photographing and public publishing
ikassem@dr.com
How to treat
TMJ??
the answer will
take two days
And more
12 CME
8
online learning
TMJ Course
Content
Day 1
Introduction
Surgical anatomy
pathology of TMJ
Clinical Diagnosis
Different treatment of TMJ pathology
10
Day 2
Medical management of TMD
laser bio stimulation
neurotoxin
compilications of TMJ treatment
11
TMJ Syndrome an outdated concept
Should be able to distinguish between
muscular disorders and joint disorders
Must rule out joint pathology
Economics
$30 Billion lost productivity
550 million work days per year
Epidemiology
10 million people treated for “TMJ” at any one
time
50% of population
1/5 require some treatment
1/10 of those treated will need surgery
Epidemiology
Avg age onset 18-26
Females 5:1
50% have progressive Sx
50% accommodate by functioning within
physiologic limits
84% not treated improve
86% treated improve
Oro-Facial Pain
What is Pain?
• “Pain is an unpleasant sensory and emotional
experience associated with actual or potential
tissue damage or described in terms of such
damage”
• “- pain is always subjective -”
Int. Assoc. for the Study of Pain
Oro-Facial Pain
• The remit of the dentist?
• Patients go to dentist to get
problem fixed
– Filling, extraction etc
• Problem arises when dentist
can’t fix it!
• Patients don’t go to dentist for
medical/psychological help!
• Dentist under pressure to do
something!
• Poor inter-professional
communication between
medicine and dentistry
• Dentists often isolated
Oro-facial Pain
• Oro-facial pain can be
difficult to diagnose!
• TMD can be a great
mimic!
• Beware of referred pain!
In the primary care setting

how much do each of the following contribute to
the diagnosis?
• History taking
• >80%
• Physical examination
• <10%
• Investigations
• <10%
• So why do we do so many investigations?
Why Do We Order So Many Tests?
• "Defensive" medicine in an increasingly
litigious environment
• Loss of confidence in our abilities to extract
meaningful information from the history and
examination
Consequences of Ordering So Many
Tests
– Time delay in diagnosis as one awaits the test
results
– The patient is exposed to the risk and side effects
of tests that may not be necessary
The pain history
• Onset, location and duration of facial pain
• Alleviating or aggravating factors
• Medical, dental & social history
KEY QUESTIONS
• IS THE PAIN PRESENT EVERY DAY ?
• WHAT IS A NORMAL DAY LIKE ?
• HOW SEVERE IS THE PAIN ? –
• (Score 0-10)
Rules of Thumb!
• Dental pain gets better or worse!
• Chronic pain is rarely dental!
• If an experienced dentist “feels” the pain is
not dental they are most often right !
5th & 7th Cranial Nerves
1. Sensory root of
trigeminal nerve
2. Pons
3. Vestibulocochlear nerve
4. Facial nerve
5. Abducent nerve
6. Medulla oblongata
7. Motor root of
trigeminal nerve
8. Basilar sulcus
Nasopharyngeal Carcinoma

(Trotter’s Syndrome)
• Maxillary pain
– With numbness!!
• Unilateral
nosebleeds
Toothache
Dental caries
Dental Pain - radiation
• Caries in mandibular
molars can produce
pain around the ear
• Caries in maxillary
teeth can produce
maxillary, orbital, retro-
orbital
Dental Pain
• Dental pain can be difficult
to diagnose!
– Tooth sleuth!
– Hot water test!
• TMD can be a great
mimic!
– Headaches, jaw pain,
toothache etc.!
• Beware of referred pain
– sinuses, cervical spine, heart
etc.!
Acute Maxillary Sinusitis
• Unilateral or bilateral
pressure, fullness or
burning pain over
cheekbone, upper teeth
and around eyes
• Exacerbated by stooping
• Usually follows an URTI
• Most cases self limiting
Chronic Maxillary Sinusitis
• Feeling of pressure below
the eyes or toothache
• Computed Tomography
• Endoscopy
Sinusitis Management
• Decongestants
• Steam inhalations
• Antibiotics if indicated
• Local Heat
• Antihistamines if allergic component
• corticosteroids
• Sinus irrigation
• Endoscopic surgery
TEMPOROMANDIBULAR JOINT
DISORDERS
• Common
• More has been written about this topic than
for any other joint !
• Various classifications
• Many cases are self limiting
• Surgery is indicated in very few BUT
important exceptions
Temporomandibular Dysfunction
• Pain in the joint and/or surrounding muscles
• Joint “clicking”
• Periods of limitation of joint movement (trismus)
EPIDEMIOLOGICAL DATA
• Percentage of population with signs
50-75%
• Percentage of population with symptoms
20-25%
• Percentage of population who seek
treatment 3-4%
Temporomandibular Dysfunction
• Causes
• Parafunction
– Bruxism
– Clenching
• Emotional stress
• Predisposition (F>M)
– Joint hypermobility
• Occlusal factors – little
evidence
Bruxism
• Tooth wear
• Painful teeth
• Cracked cusps
• Mouth ulcers due to trauma
• Jaws ache in the morning
Temporomandibular Dysfunction
• Pain distribution
• Variable – a great mimic!!
• Joint pain
• Earache
• Toothache
• Facial pain
• Headache
• Can be associated with
neck and shoulder pain
Treatment of TMD
Trigeminal Neuralgia - Description
• A painful unilateral affliction of the face,
characterized by brief electric shock-like
(lancinating) pains limited to one or more
divisions of the trigeminal nerve
• Pain evoked by washing, shaving,
smoking, talking, brushing, air blowing, or
spontaneously occurring
• Pain is abrupt in onset and may remit for
varying periods
Trigeminal Neuralgia
• Subclassified into idiopathic and
symptomatic
• Idiopathic trigeminal neuralgia: due to an
interaction between trigeminal nerve and
vasculature
• Symptomatic trigeminal neuralgia: caused
by demonstrable structural lesion
Trigeminal Neuralgia
• Females > males
• Usually elderly – (if < than 40 -?MS)
• Restricted to Vth nerve
– Similar can affect IXth nerve – glossopharyngeal
neuralgia
• Trigger point – may bear no anatomical
relation to site of pain but on same side!
• Sleep often not affected
• May go into remission
Trigeminal Neuralgia
Diagnosis:
• History
• Examination
• MRI
– aberrant pontine blood
vessel?
– exclusion of other
cause (neoplasm, MS)
• (Response to trial of
carbamazepine)
Trigeminal Neuralgia
Treatment:
• Medical – anticonvulsants
( e.g. carbamazepine) –
needs medical monitoring!
• Use of additive drugs –
e.g. baclofen
• Damage to trigger point –
alcohol injection,
cryotherapy
Trigeminal Neuralgia – Surgical
Treatment
• Radiofrequency
ganglionolysis
• Microvascular
decompression
Establishment of VZV Latency in Sensory-Nerve
Ganglia.
After a primary VZV infection (chickenpox), latent VZV
infection is established in the dorsal-root ganglia, and
zoster occurs with subsequent reactivation of the virus
N Engl J Med Vol 356(13) P1338-1343
Zoster: Clinical Features
• Usually limited to 1 or 2
adjacent, unilateral
dermatomes
• “Grape-like” lesions
clustered on an
erythematous base
• Lesions usually heal
within 4 weeks1
Post Herpetic Neuralgia
• Burning, itching, prickly pain that worsens
with contact or movement
• Persists along any of the three trigeminal
nerve distributions affected by shingles
• Difficult to treat!
• Importance of adequate treatment of
shingles – especially the elderly
• Carbamazepine, tricyclics
Giant Cell Arteritis
• Over 50yrs,women>men
• recent onset headache,scalp tenderness
• Jaw/tongue claudication (tired tongue/
jawache)
• anorexia
• visual disturbances
• Swollen disc usually
GCA Diagnosis
• ESR/CRP
• BP, CXR
• Biopsy of temporal
artery
Treatment of GCA
• Give corticosteroids immediately in all
suspected cases
• Start with 1mg/Kg prednisolone daily with vitamin
D and calcium supplements.
• Refer for Ophthalmology
Psychogenic

Somatisation Disorders
Somatisation has been defined as “the
expression of personal and social distress in
an idiom of bodily complaints with medical
help seeking”
Common !
“In general medical practice, somatisation
associated with psychiatric illness accounts
for 20 - 30% of all consultations”
DEPRESSIVE ILLNESS
• Persistent low mood (> 2weeks)
• Feeling worthless, hopeless, suicidal
• Loss of interest in usual activities
– anhedonia
• Fatigue
• Poor concentration
• Reduced sleep
• Poor appetite
Warning Signs
Atypical Pain Conditions
• Atypical = poorly understood!
• Often regarded as purely “psychogenic”!
• But chronic pain will make you depressed!
• Other factors may be involved!
– There may be a cause?
– Patient may just be a poor historian!
• Be careful of labels!
• Keep an open mind!
“Atypical” Facial Pain Conditions
• Persistent idiopathic facial pain
• Persistent dento-alveolar pain (atypical
odontalgia)
• Oral dysaesthesia
• Phantom bite syndrome
• (TMD)
• Syndrome of bizarre oro-facial symptoms
Persistent Idiopathic Facial Pain
• Middle aged or older
• Mainly female
• Constant pain / discomfort
• Poorly localised
• May cross midline
• Does not waken patient from sleep
• Lack objective signs
• Investigations (-ve)
• Other symptoms (headaches,IBS,backache etc.)
Persistent Idiopathic Facial Pain
• Demand physical treatment
• Often do not accept psychological
explanation
• May have seen several specialists/
practitioners
• May be obsessed with symptoms
Psychogenic Toothache
• Patient reports that multiple teeth are often painful with
frequent change in character and location
• A general departure from normal or physiological patterns of
pain
• Patient presents with chronic pain behaviour
• Lack of response to reasonable dental treatment
• Unusual or unexpected response to therapy
• No other identifiable pain condition that can explain the
toothache
Non-Odontogenic Toothaches 

Warning Symptoms- Summary
• Spontaneous multiple toothaches
• Inadequate local dental cause for the pain
• Stimulating, burning, non-pulsatile toothaches
• Constant, unremitting, non-variable toothaches
• Persistent, recurrent toothaches
• Local anesthetic blocking of the offending tooth does not
eliminate the pain
• Failure of the toothache to respond to reasonable dental
therapy
Chronic Orofacial pain
Burning mouth syndrome is characterized as a
burning, tender, or annoying sensation in the
mouth with no apparent mucosal lesion.
Descriptive symptom
Late middle age – elderly
Female>Male
Burning Mouth Syndrome

(glossodynia, glossopyrosis)
• Possible causes
• Haematinic deficiency
– Fe, B12, Folate
• Diabetes melitus
• Candidosis
• Dry mouth
• Denture problems
• Parafunctional
• Psychogenic
– Anxiety
• Cancerophobia+++
– Depression
Management – What You Should Do!
• History ( what’s the story in detail )
– Exacerbants, alleviation, associated features
• Exclude organic disease
• Be aware of emotional state
– Depression / anxiety (HAD score)
- Secondary gain – what benefits does the patient get
from being unwell?
• Life events – connections with onset etc.
• Discuss with GMP (with patients consent)
• Decide on need for medication / referral
Management – What You Should Do!
• Remember the patients pain is real even if a
physical cause can not be found – tact!
• Allow the patient to express themselves
– What do you understand about your pain?
– What do you feel it represents?
– Cancer phobia?
• It can take time
• Remember most complaints are regarding
communication – or lack of it!
Management Strategies 

The Pain Clinic
• Medical – drugs – alter the chemical soup!
• Surgical – nerve ablation procedures e.g. for
cancer pain
• Physiotherapy – improving activity
• Clinical Psychology – living with the problem
– Cognitative, Behavioural Therapy (CBT)
Pain Management is multidisciplinary!
Liaise closely with the GMP
Take-Home Points
• Oro-facial pain is common
• Most cases are dental
• Diagnosis can be very difficult
• Patients are frequently frustrated & very
distressed by time they reach secondary
care
• Need a lot of listening too!
Conclusions
• Careful history taking is essential to correctly
diagnose facial pain
• Remember the anatomy of the trigeminal
nerve
• Many facial pain syndromes are wrongly
attributed to disease of the teeth or sinuses
OROFACIAL PAIN
The field of Dentistry that includes the
Assessment, Diagnosis and Treatment of
Complex chronic orofacial pain and dysfunction
Oromotor and jaw behaviour disorders
Chronic facial, head and neck pain
o Head
-meninges
-skull & scalp
-nerves
-trigeminal (V)
-C2-3 (GON/LON)
o Orofacial
-sinuses
-TMJ, ear
-teeth, nerves
o Neck & shoulders
Pain generators
Red flags
T.I.N.T
o Tumour
o Temporal arteritis
o Intracranial pressure
o Infection
o Neurovascular
o Trigeminal
o Trauma
Red Flag Case Presentation
Female 16 years
Hx of constant deep aching TMJ/jaw pain worse with
chewing, extending to occiput.
Initially treated with Occlusal Splint/Physio.
Headaches on exertion - paroxysmal with “fainting”.
Parents noted subtle personality changes.
MRI - Arnold Chiari formation- surgery.
Intracranial Pathology 

Diagnostic Clues

Neurological type symptoms/signs.
No response to peripheral therapies.
Unusual or worsening symptoms despite therapy.
Negative response to somatic/sympathetic blocks.
Intracranial pathology
Common manifestations of raised intracranial pressure


Space Occupying Lesions

Neoplasms
Arterial dissection
Aneurysms
Infection/Abscess
Infarction/haemorrhage
Oedema
Angioma
Temporal (Giant cell) Arteritis
RED FLAG
Headache emergency
New onset headache in >50 years
Uni/bilateral dull temporal pain
Claudication masticatory muscles
Visual disturbance
Polymyalgia-shoulder/hip, malaise
Swollen, tender temporal artery
Elevated ESR, CRP
Positive biopsy
Temporal Arteritis
RED FLAG
Headache of vascular origin
Initial symptoms may resemble TMD
- Pain/stiffness in jaw
- Pain/fatigue of jaw when chewing
- Pain may radiate to ear, teeth
- Temporal headache
If untreated may cause blindness, stroke and death!
Generally resolves with high dose steroids
Extracranial Sources of Orofacial Pain
Teeth and oral mucosa
ENT, paranasal sinuses
TMJs &myofascial
Tongue
Salivary Glands
Lymph Glands
Eyes
Vessels & nerves
Odontogenic Pain – Toothache
â–Ş Most common cause of orofacial pain!
â–Ş Often missed by medical people
â–Ş Dental caries into dentine / pulp
â–Ş Pulpitis, pulp necrosis
â–Ş Cracked teeth
â–Ş Periodontal infection
â–Ş ASK ABOUT HOLES IN TEETH
â–Ş Hot/cold/bite SENSITIVITY, PAIN AT NIGHT
TOOTHACHE
• Toothache - most common orofacial pain complaint
• 12.2% of population reported toothache in last 6M
• Diagnosis can be challenging and complicated
• Pain from one tooth may be referred from another
tooth or from other orofacial structures
• Other craniofacial pain disorders may mimic the
symptoms of toothache
• Proper diagnosis is critical
Consider all pains in the mouth and face to be
of dental origin until proven otherwise
TEMPOROMANDIBULAR DISORDERS
Major cause of Non Dental Pain in Orofacial Region
TEMPOROMANDIBULAR DISORDERS
Collection of medical and dental conditions
affecting the temporomandibular joint and/or
muscles of mastication and/or contiguous
tissues resulting in pain and/or dysfunction
NEUROVASCULAR PAIN
Case Presentation
48 year old female
Intermittent dull throbbing pain in upper tooth/jaw,
radiating to temple and eye.
Severe attacks, last 1-3 days with constant dull pain.
When severe, feels sick and prefers dark, quiet room to
sleep.
Attacks used to respond well to NSAIDs.
Had a root canal, crown of upper premolar + splint
Migraine
Case Presentation
Male in mid forties.
Right sided face pain attacks on/off over three years
Extending into right eye.
Often awakened from sleep with severe throbbing pain.
Would get up and pace around holding his R. eye.
Face would feel sweaty, tearing of eye.
Numerous dental visits – Root canals/ extractions.
Case Presentation
EXAMINATION
Cranial nerve screen - Normal
TMJ/Myofascial – Normal
Oro-dental- Normal
Medication Trial - response to oxygen/sumatriptan
TRIGEMINALAUTONOMIC
CEPHALGIAS (TACs)
CLUSTER HEADACHE
CHRONIC PAROXYSMAL HEMICRANIA
HEMICRANIA CONTINUA
Peri-orbital or maxillary pain.
Frequently leads to dental work including extractions.
Unilateral, severe attacks with typical autonomic
headache accompanying symptoms.
Cluster Headache

Clinical Features
• Attacks are severe - boring
• Strictly unilateraln in and
around eye and/or temporal
region - “hot poker”
• Attack duration 15-180 min
• Attacks occur from once
every 2nd day up to 8x day.
• Attacks occur in series
lasting weeks to months
Remissions mths-yrs
• Autonomic features +++
• Males 5-7:1
65% had dental Tx
Chronic Paroxysmal Hemicrania
Similar to Cluster but
Female preponderance (3:1)
Attacks are more frequent and of shorter duration
5-40 attacks per day (median 5-10)
Attacks last 2-45 minutes
At least one autonomic symptom on the side of pain
conjunctival injection lacrimation
nasal congestion rhinorrhoea,
ptosis eyelid oedema
Chronic Paroxysmal Hemicrania
Always unilateral orbital, and/or temporal.
Severe stabbing/boring type pain that throbs as it builds
up.
Episodic form occursin bouts lasting months to years with
clear intervals (rare).
In most cases responds rapidly and absolutely to
Indomethacin (diagnostic test).
Tension Type Headache (TTH)
Previously called tension headache, muscle contraction
headache, stress headache
Most common primary headache (30-70% prevalence)
Episodic (frequent/infrequent) and chronic forms
Usually frontal /temporal location
Tightness, pressure in hat-band like distribution
+/- pericranial muscle tenderness
Often co morbid with migraine w/o aura.
Tension Type Headache
NOT DUE TO ABNORMAL MUSCLE CONTRACTION
Neuropathic Orofacial Pains
EPISODIC
Trigeminal Neuralgia
Glossopharyngeal Neuralgia
CONTINUOUS
Painful Traumatic Trigeminal Neuropathy
Post Herpetic Neuralgia
Persistent Idiopathic Facial Pain (PIFP)
Persistent Dento-alveolar Pain (PADP)
Burning Mouth Syndrome
Case Presentation
â–Ş 65 year old female
â–Ş Sharp shooting pains upper anterior teeth 22/23
â–Ş Saw dentist - fillings, root canals, extraction,
bridge, removal of bridge
â–Ş Inserting denture triggers sharp pain
â–Ş Repeated denture adjustments
Case Presentation
EXAMINATION
Cervical spine - normal
Cranial nerve screen - normal
TMJ/MM - normal
Myofascial - tender masseter.
Intraoral - mucosa normal appearance
trigger area palatal to 23 site.
Orofacial Neuropathic Pain
Trigeminal neuralgia
Brief, electric shock-like, lancinating pains
that affects the face unilaterally affecting one
or more divisions of the trigeminal nerve
Trigeminal Neuralgia
Intermittent brief paroxysmal pain (secs-mins)
Limited distribution: V2 and/or V3 > V1
Trigger zone –minor stimuli- touch, wind, shave
Abrupt in onset and termination and may remit
Remission period can spontaneously occur that lasts for
weeks to years, and may return
Triggerable or spontaneous
No obvious local cause
Painful Post Traumatic Trigeminal
Neuropathy (AFP, PIFP)
Unilateral facial and/or oral pain
Usually continuous +/- sharp jolts of pain
History of trauma to same V nerve branch
Positive and/or negative neurosensory signs
(allodynia, hyperalgesia, hypoesthesia etc)
Equivocal response to LA nerve block
Varying degree of central & sympathetic involvement
Case presentation
40 yo female
Complains of 3 years continuous dull aching pain in
lower left quadrant. Occasional sharp pains.
Problem commenced after periodontal surgery and
surgical extraction of third molar.
Since had RCT of 1st and 2nd molars w/o effect
Aggravated by eating on that side and brushing teeth.
Persistent Dento-Alveolar Pain
Disorder (PDAP)
(Atypical Odontalgia, Phantom tooth pain)
Continuous variable pain
Localized to dento-alveolar region – tooth/extrn sites
Usually multiple (unsuccessful) dental procedures
No obvious local pathology-clinical/radiography
Not caused by another disease or disorder
+/- Sensory abnormalities
Somatic block equivocal
Case Presentation
48 year old female
2 years continuous dull, aching, burning pain in upper
right jaw
Presumed pulpitis so over time 3 x root canals
Extractions all upper molars, now wants premolar out
Extractions only aggravated pain, which has spread
Some sinus and menopausal symptoms
Hx of depression - not current
Case Presentation
Cervical Spine - normal
Cranial Nerve Screen - normal
Stomatognathic- normal
Myofascial – trigger points but not replicating pain
Intraoral- Extraction sites hyperaesthetic
Somatic block – negative
Sympathetic block- partially positive
Cone Beam CT, MRI- normal
Persistent Dento-Alveolar Pain
Disorder (PDAP) 

(Atypical Odontalgia, Phantom Tooth pain)
Females > males – usually mid 40s on
Posterior maxillary quadrant most often
Hx of trauma - multiple dental procedures
Somatosensory abnormalities around tooth site
No evidence of psychopathology
<50% responded to LA block
Variable response to TCA, gabapentinoids, topicals etc
Repeated dental procedures are contraindicated
EETS
Excessive Endodontic Treatment Syndrome
Classification of Orofacial Pains
Somatic Pain
Superficial Pain
MucogingivalPain
Deep Pain
CutaneousPain
MusclePain
Myospasm
CentralMediatedMyalgia
MyofascialPain
LocalMuscleSoreness
ProtectiveCo-Contraction
TMJPain
OsseousPain
Connect.TissuePain
PeriodontalPain
VisceralPain
MusculoskeletalPain
VisceralMucosalPain
Glandular,ENTPain
PulpalPain
VascularPain
NeurovascularPain
CapsularPain
ArthriticPain
RetrodiscalPain
LigamentousPain
Neuropathic Pain
Episodic Pain
ParoxysmalNeuralgia
Continuous Pain
TrigeminalNeuralgia
PeripheralMediatedPain
MetabolicPolyneuropathies
CentralMediatedPain
EntrapmentNeuropathy
DeafferentationPain
NeuriticPain
BurningMouthDisorder
AtypicalOdontalgia
(PhantomPain)
NeurovascularVariants
OtherPrimaryHeadache
ClusterandotherTCA
ArteritisPain
PeripheralNeurits
HerpesZoster
PostHerpeticNeuralgia
Mood Disorders
BipolarDisorder
MoodDisorderdueto
aMedicalCondition
DepressiveDisorder
Anxiety Disorders
PosttraumaticStress
Disorder
AnxietyDisorderdueto
aMedicalCondition
GeneralizedAnxiety
Disorder
Somatoform Disorders
ConversionDisorder
PainDisorder
Undifferentiated
SomatoformDisorder
Other Conditions
PsychologicalFactors
AffectingMedCondition
OtherConditions
Malingering
Hypochondriasis
Axis II
(Psychological Conditions)
Axis I
(Physical Conditions)
OtherNeuralgias
Okeson, 2003ChronicRegional
PainSyndrome
Sympathetically Maintained Pain
Tension-Type
Migraine
Carotidynia
TraumaticNeuroma
MaladaptiveHealth
Behavior
Stress-Related
PhysiologicalResponse
PersonalityTraits
orCopingStyle
Axis I Axis II
Diagnosis
Thank you
• Islam Kassem

• ikassem@dr.com

• 00201222209842

• 002034810481

• 00201091472244
ikassem@dr.com
Break

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Introduction to TMJ

  • 1. TMJ secrets Islam Kassem,BDS,MSc,MFDS RCS Ed,MOMS RCPS Glasg,FFD RCSI Consultant Oral & Maxillofacial Surgeon
  • 2. Islam Kassem • BDS Alexandria Dental school 2002 • MSc Oral & Maxillofacial surgery 2008 • MFDS RCS Ed 2005 • MOMS RCPS Glasg 2009 • FFD RCSI OS OM 2011 • AO-CMF Fellowship 2012 • American Aesthetic fellowship diploma 2013 • Implant Diploma Napoli university 2014 • Laser Diploma ALD 2015 • Oral & Maxillofacial Surgeon
  • 3.
  • 4. Declaration
 • There is no conflict of interest in this Course . • I have no monetary benefit from this Course. • No implied sponsorship by any company to the speaker  • all photographed patients were treated by the speaker and consented for photographing and public publishing ikassem@dr.com
  • 5.
  • 10. Content Day 1 Introduction Surgical anatomy pathology of TMJ Clinical Diagnosis Different treatment of TMJ pathology 10
  • 11. Day 2 Medical management of TMD laser bio stimulation neurotoxin compilications of TMJ treatment 11
  • 12. TMJ Syndrome an outdated concept Should be able to distinguish between muscular disorders and joint disorders Must rule out joint pathology
  • 13. Economics $30 Billion lost productivity 550 million work days per year
  • 14. Epidemiology 10 million people treated for “TMJ” at any one time 50% of population 1/5 require some treatment 1/10 of those treated will need surgery
  • 15. Epidemiology Avg age onset 18-26 Females 5:1 50% have progressive Sx 50% accommodate by functioning within physiologic limits 84% not treated improve 86% treated improve
  • 16.
  • 18. What is Pain? • “Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage” • “- pain is always subjective -” Int. Assoc. for the Study of Pain
  • 19. Oro-Facial Pain • The remit of the dentist? • Patients go to dentist to get problem fixed – Filling, extraction etc • Problem arises when dentist can’t fix it! • Patients don’t go to dentist for medical/psychological help! • Dentist under pressure to do something! • Poor inter-professional communication between medicine and dentistry • Dentists often isolated
  • 20. Oro-facial Pain • Oro-facial pain can be difficult to diagnose! • TMD can be a great mimic! • Beware of referred pain!
  • 21. In the primary care setting
 how much do each of the following contribute to the diagnosis? • History taking • >80% • Physical examination • <10% • Investigations • <10% • So why do we do so many investigations?
  • 22. Why Do We Order So Many Tests? • "Defensive" medicine in an increasingly litigious environment • Loss of confidence in our abilities to extract meaningful information from the history and examination
  • 23. Consequences of Ordering So Many Tests – Time delay in diagnosis as one awaits the test results – The patient is exposed to the risk and side effects of tests that may not be necessary
  • 24. The pain history • Onset, location and duration of facial pain • Alleviating or aggravating factors • Medical, dental & social history
  • 25. KEY QUESTIONS • IS THE PAIN PRESENT EVERY DAY ? • WHAT IS A NORMAL DAY LIKE ? • HOW SEVERE IS THE PAIN ? – • (Score 0-10)
  • 26. Rules of Thumb! • Dental pain gets better or worse! • Chronic pain is rarely dental! • If an experienced dentist “feels” the pain is not dental they are most often right !
  • 27. 5th & 7th Cranial Nerves 1. Sensory root of trigeminal nerve 2. Pons 3. Vestibulocochlear nerve 4. Facial nerve 5. Abducent nerve 6. Medulla oblongata 7. Motor root of trigeminal nerve 8. Basilar sulcus
  • 28. Nasopharyngeal Carcinoma
 (Trotter’s Syndrome) • Maxillary pain – With numbness!! • Unilateral nosebleeds
  • 31. Dental Pain - radiation • Caries in mandibular molars can produce pain around the ear • Caries in maxillary teeth can produce maxillary, orbital, retro- orbital
  • 32. Dental Pain • Dental pain can be difficult to diagnose! – Tooth sleuth! – Hot water test! • TMD can be a great mimic! – Headaches, jaw pain, toothache etc.! • Beware of referred pain – sinuses, cervical spine, heart etc.!
  • 33. Acute Maxillary Sinusitis • Unilateral or bilateral pressure, fullness or burning pain over cheekbone, upper teeth and around eyes • Exacerbated by stooping • Usually follows an URTI • Most cases self limiting
  • 34. Chronic Maxillary Sinusitis • Feeling of pressure below the eyes or toothache • Computed Tomography • Endoscopy
  • 35. Sinusitis Management • Decongestants • Steam inhalations • Antibiotics if indicated • Local Heat • Antihistamines if allergic component • corticosteroids • Sinus irrigation • Endoscopic surgery
  • 36. TEMPOROMANDIBULAR JOINT DISORDERS • Common • More has been written about this topic than for any other joint ! • Various classifications • Many cases are self limiting • Surgery is indicated in very few BUT important exceptions
  • 37. Temporomandibular Dysfunction • Pain in the joint and/or surrounding muscles • Joint “clicking” • Periods of limitation of joint movement (trismus)
  • 38. EPIDEMIOLOGICAL DATA • Percentage of population with signs 50-75% • Percentage of population with symptoms 20-25% • Percentage of population who seek treatment 3-4%
  • 39. Temporomandibular Dysfunction • Causes • Parafunction – Bruxism – Clenching • Emotional stress • Predisposition (F>M) – Joint hypermobility • Occlusal factors – little evidence
  • 40. Bruxism • Tooth wear • Painful teeth • Cracked cusps • Mouth ulcers due to trauma • Jaws ache in the morning
  • 41. Temporomandibular Dysfunction • Pain distribution • Variable – a great mimic!! • Joint pain • Earache • Toothache • Facial pain • Headache • Can be associated with neck and shoulder pain
  • 43. Trigeminal Neuralgia - Description • A painful unilateral affliction of the face, characterized by brief electric shock-like (lancinating) pains limited to one or more divisions of the trigeminal nerve • Pain evoked by washing, shaving, smoking, talking, brushing, air blowing, or spontaneously occurring • Pain is abrupt in onset and may remit for varying periods
  • 44. Trigeminal Neuralgia • Subclassified into idiopathic and symptomatic • Idiopathic trigeminal neuralgia: due to an interaction between trigeminal nerve and vasculature • Symptomatic trigeminal neuralgia: caused by demonstrable structural lesion
  • 45. Trigeminal Neuralgia • Females > males • Usually elderly – (if < than 40 -?MS) • Restricted to Vth nerve – Similar can affect IXth nerve – glossopharyngeal neuralgia • Trigger point – may bear no anatomical relation to site of pain but on same side! • Sleep often not affected • May go into remission
  • 46. Trigeminal Neuralgia Diagnosis: • History • Examination • MRI – aberrant pontine blood vessel? – exclusion of other cause (neoplasm, MS) • (Response to trial of carbamazepine)
  • 47. Trigeminal Neuralgia Treatment: • Medical – anticonvulsants ( e.g. carbamazepine) – needs medical monitoring! • Use of additive drugs – e.g. baclofen • Damage to trigger point – alcohol injection, cryotherapy
  • 48. Trigeminal Neuralgia – Surgical Treatment • Radiofrequency ganglionolysis • Microvascular decompression
  • 49. Establishment of VZV Latency in Sensory-Nerve Ganglia. After a primary VZV infection (chickenpox), latent VZV infection is established in the dorsal-root ganglia, and zoster occurs with subsequent reactivation of the virus N Engl J Med Vol 356(13) P1338-1343
  • 50. Zoster: Clinical Features • Usually limited to 1 or 2 adjacent, unilateral dermatomes • “Grape-like” lesions clustered on an erythematous base • Lesions usually heal within 4 weeks1
  • 51. Post Herpetic Neuralgia • Burning, itching, prickly pain that worsens with contact or movement • Persists along any of the three trigeminal nerve distributions affected by shingles • Difficult to treat! • Importance of adequate treatment of shingles – especially the elderly • Carbamazepine, tricyclics
  • 52. Giant Cell Arteritis • Over 50yrs,women>men • recent onset headache,scalp tenderness • Jaw/tongue claudication (tired tongue/ jawache) • anorexia • visual disturbances • Swollen disc usually
  • 53. GCA Diagnosis • ESR/CRP • BP, CXR • Biopsy of temporal artery
  • 54. Treatment of GCA • Give corticosteroids immediately in all suspected cases • Start with 1mg/Kg prednisolone daily with vitamin D and calcium supplements. • Refer for Ophthalmology
  • 55. Psychogenic
 Somatisation Disorders Somatisation has been defined as “the expression of personal and social distress in an idiom of bodily complaints with medical help seeking”
  • 56. Common ! “In general medical practice, somatisation associated with psychiatric illness accounts for 20 - 30% of all consultations”
  • 57. DEPRESSIVE ILLNESS • Persistent low mood (> 2weeks) • Feeling worthless, hopeless, suicidal • Loss of interest in usual activities – anhedonia • Fatigue • Poor concentration • Reduced sleep • Poor appetite Warning Signs
  • 58. Atypical Pain Conditions • Atypical = poorly understood! • Often regarded as purely “psychogenic”! • But chronic pain will make you depressed! • Other factors may be involved! – There may be a cause? – Patient may just be a poor historian! • Be careful of labels! • Keep an open mind!
  • 59. “Atypical” Facial Pain Conditions • Persistent idiopathic facial pain • Persistent dento-alveolar pain (atypical odontalgia) • Oral dysaesthesia • Phantom bite syndrome • (TMD) • Syndrome of bizarre oro-facial symptoms
  • 60. Persistent Idiopathic Facial Pain • Middle aged or older • Mainly female • Constant pain / discomfort • Poorly localised • May cross midline • Does not waken patient from sleep • Lack objective signs • Investigations (-ve) • Other symptoms (headaches,IBS,backache etc.)
  • 61. Persistent Idiopathic Facial Pain • Demand physical treatment • Often do not accept psychological explanation • May have seen several specialists/ practitioners • May be obsessed with symptoms
  • 62. Psychogenic Toothache • Patient reports that multiple teeth are often painful with frequent change in character and location • A general departure from normal or physiological patterns of pain • Patient presents with chronic pain behaviour • Lack of response to reasonable dental treatment • Unusual or unexpected response to therapy • No other identifiable pain condition that can explain the toothache
  • 63. Non-Odontogenic Toothaches 
 Warning Symptoms- Summary • Spontaneous multiple toothaches • Inadequate local dental cause for the pain • Stimulating, burning, non-pulsatile toothaches • Constant, unremitting, non-variable toothaches • Persistent, recurrent toothaches • Local anesthetic blocking of the offending tooth does not eliminate the pain • Failure of the toothache to respond to reasonable dental therapy
  • 64. Chronic Orofacial pain Burning mouth syndrome is characterized as a burning, tender, or annoying sensation in the mouth with no apparent mucosal lesion. Descriptive symptom Late middle age – elderly Female>Male
  • 65. Burning Mouth Syndrome
 (glossodynia, glossopyrosis) • Possible causes • Haematinic deficiency – Fe, B12, Folate • Diabetes melitus • Candidosis • Dry mouth • Denture problems • Parafunctional • Psychogenic – Anxiety • Cancerophobia+++ – Depression
  • 66. Management – What You Should Do! • History ( what’s the story in detail ) – Exacerbants, alleviation, associated features • Exclude organic disease • Be aware of emotional state – Depression / anxiety (HAD score) - Secondary gain – what benefits does the patient get from being unwell? • Life events – connections with onset etc. • Discuss with GMP (with patients consent) • Decide on need for medication / referral
  • 67. Management – What You Should Do! • Remember the patients pain is real even if a physical cause can not be found – tact! • Allow the patient to express themselves – What do you understand about your pain? – What do you feel it represents? – Cancer phobia? • It can take time • Remember most complaints are regarding communication – or lack of it!
  • 68. Management Strategies 
 The Pain Clinic • Medical – drugs – alter the chemical soup! • Surgical – nerve ablation procedures e.g. for cancer pain • Physiotherapy – improving activity • Clinical Psychology – living with the problem – Cognitative, Behavioural Therapy (CBT) Pain Management is multidisciplinary! Liaise closely with the GMP
  • 69. Take-Home Points • Oro-facial pain is common • Most cases are dental • Diagnosis can be very difficult • Patients are frequently frustrated & very distressed by time they reach secondary care • Need a lot of listening too!
  • 70. Conclusions • Careful history taking is essential to correctly diagnose facial pain • Remember the anatomy of the trigeminal nerve • Many facial pain syndromes are wrongly attributed to disease of the teeth or sinuses
  • 71. OROFACIAL PAIN The field of Dentistry that includes the Assessment, Diagnosis and Treatment of Complex chronic orofacial pain and dysfunction Oromotor and jaw behaviour disorders Chronic facial, head and neck pain
  • 72. o Head -meninges -skull & scalp -nerves -trigeminal (V) -C2-3 (GON/LON) o Orofacial -sinuses -TMJ, ear -teeth, nerves o Neck & shoulders Pain generators
  • 73. Red flags T.I.N.T o Tumour o Temporal arteritis o Intracranial pressure o Infection o Neurovascular o Trigeminal o Trauma
  • 74. Red Flag Case Presentation Female 16 years Hx of constant deep aching TMJ/jaw pain worse with chewing, extending to occiput. Initially treated with Occlusal Splint/Physio. Headaches on exertion - paroxysmal with “fainting”. Parents noted subtle personality changes. MRI - Arnold Chiari formation- surgery.
  • 75. Intracranial Pathology 
 Diagnostic Clues
 Neurological type symptoms/signs. No response to peripheral therapies. Unusual or worsening symptoms despite therapy. Negative response to somatic/sympathetic blocks.
  • 76. Intracranial pathology Common manifestations of raised intracranial pressure
  • 77. 
 Space Occupying Lesions
 Neoplasms Arterial dissection Aneurysms Infection/Abscess Infarction/haemorrhage Oedema Angioma
  • 78. Temporal (Giant cell) Arteritis RED FLAG Headache emergency New onset headache in >50 years Uni/bilateral dull temporal pain Claudication masticatory muscles Visual disturbance Polymyalgia-shoulder/hip, malaise Swollen, tender temporal artery Elevated ESR, CRP Positive biopsy
  • 79. Temporal Arteritis RED FLAG Headache of vascular origin Initial symptoms may resemble TMD - Pain/stiffness in jaw - Pain/fatigue of jaw when chewing - Pain may radiate to ear, teeth - Temporal headache If untreated may cause blindness, stroke and death! Generally resolves with high dose steroids
  • 80. Extracranial Sources of Orofacial Pain Teeth and oral mucosa ENT, paranasal sinuses TMJs &myofascial Tongue Salivary Glands Lymph Glands Eyes Vessels & nerves
  • 81. Odontogenic Pain – Toothache â–Ş Most common cause of orofacial pain! â–Ş Often missed by medical people â–Ş Dental caries into dentine / pulp â–Ş Pulpitis, pulp necrosis â–Ş Cracked teeth â–Ş Periodontal infection â–Ş ASK ABOUT HOLES IN TEETH â–Ş Hot/cold/bite SENSITIVITY, PAIN AT NIGHT
  • 82. TOOTHACHE • Toothache - most common orofacial pain complaint • 12.2% of population reported toothache in last 6M • Diagnosis can be challenging and complicated • Pain from one tooth may be referred from another tooth or from other orofacial structures • Other craniofacial pain disorders may mimic the symptoms of toothache • Proper diagnosis is critical
  • 83. Consider all pains in the mouth and face to be of dental origin until proven otherwise
  • 84. TEMPOROMANDIBULAR DISORDERS Major cause of Non Dental Pain in Orofacial Region
  • 85. TEMPOROMANDIBULAR DISORDERS Collection of medical and dental conditions affecting the temporomandibular joint and/or muscles of mastication and/or contiguous tissues resulting in pain and/or dysfunction
  • 87. Case Presentation 48 year old female Intermittent dull throbbing pain in upper tooth/jaw, radiating to temple and eye. Severe attacks, last 1-3 days with constant dull pain. When severe, feels sick and prefers dark, quiet room to sleep. Attacks used to respond well to NSAIDs. Had a root canal, crown of upper premolar + splint
  • 89. Case Presentation Male in mid forties. Right sided face pain attacks on/off over three years Extending into right eye. Often awakened from sleep with severe throbbing pain. Would get up and pace around holding his R. eye. Face would feel sweaty, tearing of eye. Numerous dental visits – Root canals/ extractions.
  • 90. Case Presentation EXAMINATION Cranial nerve screen - Normal TMJ/Myofascial – Normal Oro-dental- Normal Medication Trial - response to oxygen/sumatriptan
  • 91. TRIGEMINALAUTONOMIC CEPHALGIAS (TACs) CLUSTER HEADACHE CHRONIC PAROXYSMAL HEMICRANIA HEMICRANIA CONTINUA Peri-orbital or maxillary pain. Frequently leads to dental work including extractions. Unilateral, severe attacks with typical autonomic headache accompanying symptoms.
  • 92. Cluster Headache
 Clinical Features • Attacks are severe - boring • Strictly unilateraln in and around eye and/or temporal region - “hot poker” • Attack duration 15-180 min • Attacks occur from once every 2nd day up to 8x day. • Attacks occur in series lasting weeks to months Remissions mths-yrs • Autonomic features +++ • Males 5-7:1 65% had dental Tx
  • 93. Chronic Paroxysmal Hemicrania Similar to Cluster but Female preponderance (3:1) Attacks are more frequent and of shorter duration 5-40 attacks per day (median 5-10) Attacks last 2-45 minutes At least one autonomic symptom on the side of pain conjunctival injection lacrimation nasal congestion rhinorrhoea, ptosis eyelid oedema
  • 94. Chronic Paroxysmal Hemicrania Always unilateral orbital, and/or temporal. Severe stabbing/boring type pain that throbs as it builds up. Episodic form occursin bouts lasting months to years with clear intervals (rare). In most cases responds rapidly and absolutely to Indomethacin (diagnostic test).
  • 95. Tension Type Headache (TTH) Previously called tension headache, muscle contraction headache, stress headache Most common primary headache (30-70% prevalence) Episodic (frequent/infrequent) and chronic forms Usually frontal /temporal location Tightness, pressure in hat-band like distribution +/- pericranial muscle tenderness Often co morbid with migraine w/o aura.
  • 96. Tension Type Headache NOT DUE TO ABNORMAL MUSCLE CONTRACTION
  • 97. Neuropathic Orofacial Pains EPISODIC Trigeminal Neuralgia Glossopharyngeal Neuralgia CONTINUOUS Painful Traumatic Trigeminal Neuropathy Post Herpetic Neuralgia Persistent Idiopathic Facial Pain (PIFP) Persistent Dento-alveolar Pain (PADP) Burning Mouth Syndrome
  • 98. Case Presentation â–Ş 65 year old female â–Ş Sharp shooting pains upper anterior teeth 22/23 â–Ş Saw dentist - fillings, root canals, extraction, bridge, removal of bridge â–Ş Inserting denture triggers sharp pain â–Ş Repeated denture adjustments
  • 99. Case Presentation EXAMINATION Cervical spine - normal Cranial nerve screen - normal TMJ/MM - normal Myofascial - tender masseter. Intraoral - mucosa normal appearance trigger area palatal to 23 site.
  • 101. Trigeminal neuralgia Brief, electric shock-like, lancinating pains that affects the face unilaterally affecting one or more divisions of the trigeminal nerve
  • 102. Trigeminal Neuralgia Intermittent brief paroxysmal pain (secs-mins) Limited distribution: V2 and/or V3 > V1 Trigger zone –minor stimuli- touch, wind, shave Abrupt in onset and termination and may remit Remission period can spontaneously occur that lasts for weeks to years, and may return Triggerable or spontaneous No obvious local cause
  • 103. Painful Post Traumatic Trigeminal Neuropathy (AFP, PIFP) Unilateral facial and/or oral pain Usually continuous +/- sharp jolts of pain History of trauma to same V nerve branch Positive and/or negative neurosensory signs (allodynia, hyperalgesia, hypoesthesia etc) Equivocal response to LA nerve block Varying degree of central & sympathetic involvement
  • 104. Case presentation 40 yo female Complains of 3 years continuous dull aching pain in lower left quadrant. Occasional sharp pains. Problem commenced after periodontal surgery and surgical extraction of third molar. Since had RCT of 1st and 2nd molars w/o effect Aggravated by eating on that side and brushing teeth.
  • 105. Persistent Dento-Alveolar Pain Disorder (PDAP) (Atypical Odontalgia, Phantom tooth pain) Continuous variable pain Localized to dento-alveolar region – tooth/extrn sites Usually multiple (unsuccessful) dental procedures No obvious local pathology-clinical/radiography Not caused by another disease or disorder +/- Sensory abnormalities Somatic block equivocal
  • 106. Case Presentation 48 year old female 2 years continuous dull, aching, burning pain in upper right jaw Presumed pulpitis so over time 3 x root canals Extractions all upper molars, now wants premolar out Extractions only aggravated pain, which has spread Some sinus and menopausal symptoms Hx of depression - not current
  • 107. Case Presentation Cervical Spine - normal Cranial Nerve Screen - normal Stomatognathic- normal Myofascial – trigger points but not replicating pain Intraoral- Extraction sites hyperaesthetic Somatic block – negative Sympathetic block- partially positive Cone Beam CT, MRI- normal
  • 108. Persistent Dento-Alveolar Pain Disorder (PDAP) 
 (Atypical Odontalgia, Phantom Tooth pain) Females > males – usually mid 40s on Posterior maxillary quadrant most often Hx of trauma - multiple dental procedures Somatosensory abnormalities around tooth site No evidence of psychopathology <50% responded to LA block Variable response to TCA, gabapentinoids, topicals etc Repeated dental procedures are contraindicated
  • 110. Classification of Orofacial Pains Somatic Pain Superficial Pain MucogingivalPain Deep Pain CutaneousPain MusclePain Myospasm CentralMediatedMyalgia MyofascialPain LocalMuscleSoreness ProtectiveCo-Contraction TMJPain OsseousPain Connect.TissuePain PeriodontalPain VisceralPain MusculoskeletalPain VisceralMucosalPain Glandular,ENTPain PulpalPain VascularPain NeurovascularPain CapsularPain ArthriticPain RetrodiscalPain LigamentousPain Neuropathic Pain Episodic Pain ParoxysmalNeuralgia Continuous Pain TrigeminalNeuralgia PeripheralMediatedPain MetabolicPolyneuropathies CentralMediatedPain EntrapmentNeuropathy DeafferentationPain NeuriticPain BurningMouthDisorder AtypicalOdontalgia (PhantomPain) NeurovascularVariants OtherPrimaryHeadache ClusterandotherTCA ArteritisPain PeripheralNeurits HerpesZoster PostHerpeticNeuralgia Mood Disorders BipolarDisorder MoodDisorderdueto aMedicalCondition DepressiveDisorder Anxiety Disorders PosttraumaticStress Disorder AnxietyDisorderdueto aMedicalCondition GeneralizedAnxiety Disorder Somatoform Disorders ConversionDisorder PainDisorder Undifferentiated SomatoformDisorder Other Conditions PsychologicalFactors AffectingMedCondition OtherConditions Malingering Hypochondriasis Axis II (Psychological Conditions) Axis I (Physical Conditions) OtherNeuralgias Okeson, 2003ChronicRegional PainSyndrome Sympathetically Maintained Pain Tension-Type Migraine Carotidynia TraumaticNeuroma MaladaptiveHealth Behavior Stress-Related PhysiologicalResponse PersonalityTraits orCopingStyle Axis I Axis II Diagnosis
  • 111. Thank you • Islam Kassem • ikassem@dr.com • 00201222209842 • 002034810481 • 00201091472244