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Trigeminal Neuralgia
DR DILIP KUMAR M
D N B ( N E U RO S U RG ERY)
C O N S U LTA N T N E U RO S U RG EO N
L.B NAGAR, HYDERABAD
Date: 14-07-2018
Also known as –
• Tic doloureux
• Suicide disease
What is a Trigeminal Neuralgia ?
Defined by - International Association for the Study of Pain (ISAP)
•“ A sudden and usually unilateral severe brief stabbing , recurrent pain in the
distribution of one or more branches of the fifth cranial nerve.”
•It is an excruciating, short-lasting (<2 minutes), unilateral facial pain that may be
spontaneous or triggered by gentle, innocuous stimuli and separated by pain-
free intervals of varying duration
Why trigeminal neuralgia is important
• One of the most excruciating, agonising pains
• Recurrent episodes
• Disturbs the quality of life significantly
• Often wrongly diagnosed as pain of “dental origin” and patient may end up
with teeth extraction before the actual diagnosis is made
• Can cause severe psychological disturbances, patients may even develop
suicidal tendencies
Epidemiology
• Incidence - 4.3 per 100,000
• Female > male ( male preponderance in Indian studies)
• Right side > Left side ( 3:2)
• Mostly unilateral (95%)
• Bilateral (5%) ----- 18% in pts with MS (multiple sclerosis)
Most common age group : 50 -70 years
What is the cause ?
Neuro-vascular conflict
VASCULAR COMPRESSION
1. Superior Cerebellar A.
2. AICA
3. Serpentine Basilar A.
4. PICA.
5. Large pontine branches of Basilar A.
6. Combination of the above.
1. Superior Petrosal V.
2. Transverse Pontine V.
3. V. of Cerebellopontine fissure.
4. V. of Middle Cerebellar Peduncle.
5. Common stem of veins draining the lateral
part of cerebellar hemisphere.
ARTERIAL VENOUS
MIXED - ARTERIAL AND VENOUS
Most commonly involved division is V2 ( maxillary nerve)
MC – involved
V 2 + V3
V2
Trigger Zones
Nasolabial fold
Upper lip
Tooth
Triggering factors
Eating, talking, smiling, exposure to cold breeze, shaving
Patient fears to eat or brush ..
* Unshaved, Halitotic, cachectic appearance
Clinical features
Not all facial pains are trigeminal neuralgias
 Taking a good history
Atypical Trigeminal Neuralgia – TN 2
• Pain is aching, throbbing or burning for more than 50% of the time
and there is constant background pain but strictly confined to the
anatomical distribution of the trigeminal divisions.
• Can be multiple neurovascular conflicts
Pathology
Idiopathic / Primary Trigeminal Neuralgia – due to NV conflict
Secondary TN
• Normal neurological examination
• May be decreased sensation over involving area
• Absent corneal sensation – suspect CP angle tumor
• Hypertension (Neurogenic HTN )
• d/t Vascular compression over vagal REZ / ventrolateral medulla
• After MVD surgery  reports of disappearance of hypertension
TN- on contralateral side of CP angle tumor due to
1. Brian stem distortion
2. Arachnoiditis
3. Contralateral vascular cross compression
** INSPITE OF PRESENCE OF CP ANGLE MASS – ACTUAL VASCULAR COMPRESSION CAN BE
A CAUSE OF TN. In such cases ONLY TUMOR EXCSION WILL Not RELIEVE PAIN . MVD is
REQUIRED
Imaging
3D- FIESTA MRI scan
MRI features
Management of TN
1. Management of severe pain – crisis in ER
2. Medical Management
3. Surgical Management
a) Percutaneous procedures
b) Microvascular Decompression (MVD)
4. Stereotactic radiosurgery
Management of acute crisis in ER
• NSAIDS and Opiates usually do not work
• No best medication yet in acute episode
• i.v infusion of Fosphenytoin – useful in some pateints ( needs ECG
monitoring)
• Local 8% spray of lidocaine
Medical management
Psychological support
• The fear, loneliness, and depression associated with TN may require
psychological, social, or other nonmedical help.
• Support groups can help to reduce feelings of isolation and despair
and can also provide high-quality information
1. Radiofrequency ablation
2. Glycerol Rhizotomy
3. Balloon Rhizotomy
Percutaneous procedures
Percutaneous procedures
Percutaneous procedures are NOT first choice
Indications
1. Failed medical therapy
2. Unfit for MVD
3. Elderly > 65 years age
4. Previously failed MVD
5. TN – secondary to MS, Pontine infarction, Brain stem white matter
lesions
Microvascular decompression
Contraindications for surgery
complications
Radiosurgery
• Ablate the cisternal part of the trigeminal nerve with gamma knife
radiosurgery
• Linear accelerator based radiosurgery seems to be nearly as effective
• Takes time to show response – ( 4 weeks to 6 months)
• Recurrence rates are upto 25 %
• Radiosurgery may be indicated after a failed MVD or other measures
Recurrence rates
• Glycerol 54% (4 years)
• RF rhizotomy 23% (6 years)
• Balloon 21% (2 years)
• Radiosurgery 25% (3 years)
• MVD 15% (5 years)
MVD – Offers most
effective immediate
pain relief and
less recurrence
Microvascular decompression (MVD)
MVD - Video
Our Results
• Total no of cases: 35
• Duration : May 2014 to till date
• Follow up: No recurrence
• Complications : paradoxical csf rhinnorhea -1, improved
Facial nerve
Hemifacial spasm
Lower cranial nerves
LAKDIKAPUL & L.B NAGAR, HYDERABAD
THANK YOU
Questions
LAKDIKAPUL & L.B NAGAR, HYDERABAD
Dr Ramakrishna chowdary y
M.S, M.Ch (neurosurgery)
CONSULTANT Neurosurgeon

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TRIGEMINAL NEURALGIA - Dr Dilip kumar Macharla.pptx

  • 1. Trigeminal Neuralgia DR DILIP KUMAR M D N B ( N E U RO S U RG ERY) C O N S U LTA N T N E U RO S U RG EO N L.B NAGAR, HYDERABAD Date: 14-07-2018
  • 2. Also known as – • Tic doloureux • Suicide disease
  • 3. What is a Trigeminal Neuralgia ? Defined by - International Association for the Study of Pain (ISAP) •“ A sudden and usually unilateral severe brief stabbing , recurrent pain in the distribution of one or more branches of the fifth cranial nerve.” •It is an excruciating, short-lasting (<2 minutes), unilateral facial pain that may be spontaneous or triggered by gentle, innocuous stimuli and separated by pain- free intervals of varying duration
  • 4. Why trigeminal neuralgia is important • One of the most excruciating, agonising pains • Recurrent episodes • Disturbs the quality of life significantly • Often wrongly diagnosed as pain of “dental origin” and patient may end up with teeth extraction before the actual diagnosis is made • Can cause severe psychological disturbances, patients may even develop suicidal tendencies
  • 5. Epidemiology • Incidence - 4.3 per 100,000 • Female > male ( male preponderance in Indian studies) • Right side > Left side ( 3:2) • Mostly unilateral (95%) • Bilateral (5%) ----- 18% in pts with MS (multiple sclerosis)
  • 6. Most common age group : 50 -70 years
  • 7. What is the cause ? Neuro-vascular conflict
  • 8. VASCULAR COMPRESSION 1. Superior Cerebellar A. 2. AICA 3. Serpentine Basilar A. 4. PICA. 5. Large pontine branches of Basilar A. 6. Combination of the above. 1. Superior Petrosal V. 2. Transverse Pontine V. 3. V. of Cerebellopontine fissure. 4. V. of Middle Cerebellar Peduncle. 5. Common stem of veins draining the lateral part of cerebellar hemisphere. ARTERIAL VENOUS MIXED - ARTERIAL AND VENOUS
  • 9. Most commonly involved division is V2 ( maxillary nerve) MC – involved V 2 + V3 V2
  • 10. Trigger Zones Nasolabial fold Upper lip Tooth Triggering factors Eating, talking, smiling, exposure to cold breeze, shaving Patient fears to eat or brush .. * Unshaved, Halitotic, cachectic appearance
  • 12. Not all facial pains are trigeminal neuralgias  Taking a good history
  • 13.
  • 14. Atypical Trigeminal Neuralgia – TN 2 • Pain is aching, throbbing or burning for more than 50% of the time and there is constant background pain but strictly confined to the anatomical distribution of the trigeminal divisions. • Can be multiple neurovascular conflicts
  • 15. Pathology Idiopathic / Primary Trigeminal Neuralgia – due to NV conflict Secondary TN
  • 16. • Normal neurological examination • May be decreased sensation over involving area • Absent corneal sensation – suspect CP angle tumor • Hypertension (Neurogenic HTN ) • d/t Vascular compression over vagal REZ / ventrolateral medulla • After MVD surgery  reports of disappearance of hypertension
  • 17. TN- on contralateral side of CP angle tumor due to 1. Brian stem distortion 2. Arachnoiditis 3. Contralateral vascular cross compression ** INSPITE OF PRESENCE OF CP ANGLE MASS – ACTUAL VASCULAR COMPRESSION CAN BE A CAUSE OF TN. In such cases ONLY TUMOR EXCSION WILL Not RELIEVE PAIN . MVD is REQUIRED
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  • 23. Management of TN 1. Management of severe pain – crisis in ER 2. Medical Management 3. Surgical Management a) Percutaneous procedures b) Microvascular Decompression (MVD) 4. Stereotactic radiosurgery
  • 24. Management of acute crisis in ER • NSAIDS and Opiates usually do not work • No best medication yet in acute episode • i.v infusion of Fosphenytoin – useful in some pateints ( needs ECG monitoring) • Local 8% spray of lidocaine
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  • 27. Psychological support • The fear, loneliness, and depression associated with TN may require psychological, social, or other nonmedical help. • Support groups can help to reduce feelings of isolation and despair and can also provide high-quality information
  • 28. 1. Radiofrequency ablation 2. Glycerol Rhizotomy 3. Balloon Rhizotomy Percutaneous procedures
  • 30. Percutaneous procedures are NOT first choice Indications 1. Failed medical therapy 2. Unfit for MVD 3. Elderly > 65 years age 4. Previously failed MVD 5. TN – secondary to MS, Pontine infarction, Brain stem white matter lesions
  • 34. Radiosurgery • Ablate the cisternal part of the trigeminal nerve with gamma knife radiosurgery • Linear accelerator based radiosurgery seems to be nearly as effective • Takes time to show response – ( 4 weeks to 6 months) • Recurrence rates are upto 25 % • Radiosurgery may be indicated after a failed MVD or other measures
  • 35. Recurrence rates • Glycerol 54% (4 years) • RF rhizotomy 23% (6 years) • Balloon 21% (2 years) • Radiosurgery 25% (3 years) • MVD 15% (5 years) MVD – Offers most effective immediate pain relief and less recurrence
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  • 43. Our Results • Total no of cases: 35 • Duration : May 2014 to till date • Follow up: No recurrence • Complications : paradoxical csf rhinnorhea -1, improved
  • 47. LAKDIKAPUL & L.B NAGAR, HYDERABAD THANK YOU
  • 48. Questions LAKDIKAPUL & L.B NAGAR, HYDERABAD Dr Ramakrishna chowdary y M.S, M.Ch (neurosurgery) CONSULTANT Neurosurgeon