Oncolytic viruses (OVs) is a group of viruses that selectively replicate in and kill cancer cells, while leaving the normal tissue uninfected. OVs provide a diverse platform for immunotherapy; they act as in situ vaccines, and can be armed with immuno-modulatory transgenes or combined with other immunotherapies, such as immune-checkpoint inhibitor. https://www.creative-biolabs.com/oncolytic-virus/introduction-and-mechanism-of-oncolytic-virus-therapy.htm

1. Oncolytic Virus Immunotherapy

2. Contents
Definition of Oncolytic Virus Immunotherapy
History of Oncolytic Virus Immunotherapy
Properties of Oncolytic Viruses
Mechanism of Action of Oncolytic Viruses
Clinical Trials of Oncolytic Virus Immunotherapy
Approved Oncolytic Virus Immunotherapy
Oncolytic Virus Combination Therapy

3. Oncolytic virus immunotherapy is a therapeutic approach to cancer
treatment that utilizes native or genetically modified viruses that
selectively replicate within tumor cells.
Definition of Oncolytic Virus Immunotherapy

4. History of Oncolytic Virus Immunotherapy

5. Properties of Oncolytic Viruses
ss/ds DNA or RNA genome
ability to infect host cells and replicate
directly infect and lyse tumor cells in situ
do not require tumor-associated antigens in the vector

6. Oncolytic DNA viruses

7. Oncolytic RNA viruses

8. Mechanism of Action of Oncolytic Viruses
entry into cancer cells
exploit cancer immune evasion pathway
directly lytic effect on tumor cells
induce systemic anti-tumor immunity
target oncogenic pathways

9. Oncolytic viruses entry into cancer cells

10. Oncolytic viruses exploit cancer immune evasion pathways

11. Oncolytic viruses induce local and systemic anti-tumor immunity

12. Oncolytic viruses can target oncogenic pathways

13. Clinical Trials of Oncolytic Virus Immunotherapy

14. Key oncolytic viruses in clinical trials

15. Approved Oncolytic Virus Immunotherapy
Virus Trade name Developer Indication Approval
Ad5 H101
安柯瑞Oncorine®
ECHO-7 2014 2015 2016
2005
HSV-1 2015 2015
Nasopharyngeal
carcinoma
Melanoma
Metastatic
melanoma

16. Oncolytic Virus Combination Therapy
Combination with Adoptive T Cell Therapy
Combination with Immune Checkpoint Inhibitors
Combination with Cytokines
Combination with Cancer Vaccines
Combination with Chemoradiotherapy

17. Combination with adoptive T cell therapy

18. Combination with immune checkpoint inhibitors

19. Combination with cytokines

20. Immunostimulatory transgenes encoded by oncolytic viruses
Combination with cytokines

21. Combination with cancer vaccines

22. Thanks!