A presentation showing the various manifestations of systemic diseases on the skin.

1. January 31st, 2023
Dermatologic
Manifestations
of Systemic
Diseases

2. Expressing the diseases of….
• Cardiovascular
• Nervous
• Immunological
• Hematology
• Renal
• Endocrine
• Gastrointestinal

4. General
Clubbing (CHD,IE,AVshunts/aneurysms)
Cyanosis(CHD,LHF)

5. Mitralfascies(MS) Edema(RHF)

6. Xanthelasma
Tendonxanthomas
Hyperlipidemias

7. OslerNodes
Petechiae SplinterHemorrhages
Nail-foldinfarcts
JanewayLesions
IE

8. Acute Rheumatic Fever
Erythemamargiatum Subcutaneousnodules

10. Caf
é
-au-laitspots
Cutaneousneurofibromas
Port-winestain
Neuro
fi
bromatosis 1
Sturge Weber

11. Ash-leafspots Shagreenpatches
Tuberous Sclerosis

13. Sarcoidosis, the great imitator
Annularsarcoidosis
Erythemanodosum
Lupuspernio

14. SLE → Cutaneous LE (CLE)
Acute (ACLE)
Butterfly “malar” rash BulluosLE

15. Subacute (SCLE) Chronic (CCLE)
Annular Papulosuamous Discoid

16. Scleroderma
Di
ff
use: widespread + rapid, early visceral involvement.
Limited: localized (CREST) + late visceral involvement.
Calcinosis Raynaud+Sclerodactyly

19. Iron deficiency anemia
Pallor,Skindrynessandcoarsening,
Stomatitis, Angularcheilitis
Glossitis

20. Brittlenails koilonychia

21. ITP
Usuallyasymptomatic,mostlypetechiaeandafewecchymosesfoundon
examination,Oralbloodblisterswithgastrointestinalormucocutaneous
bleedingcanalsooccurandarereferredtoaswet purpura.
Oralpetechiae/purpura-lowerlip
Petechiaonthetongue&leg(plt= 3)

23. HSP
Palpablepurpuraiscommonlyapresentingsign.
•Usuallybeginsaserythematous,macular,orurticarialwheals.
•Whealscoalesceintopetechiaeandpalpablepurpura.
•Generallyfoundindependentareaslikelegsandbuttocks.

24. Purpurainvolvingthelower
extremitiesandthebuttocks
Severepalpablepurpuraof
HSPin13yearsoldgirl

25. DIC
PurpurafulminansisasevereskindisordertypicallyassociatedwithDIC.
Patientsarehypotensivewithreducedperipheralperfusion,contributingtotheskin
necrosisondistalextremitiesandelsewhere.Sometimes,skinnecrosisoccursina
patchydistribution.
Extensivegeographicareas
ofcutaneousinfarctionwith
hemorrhage involvingthe
face,breast,andextremities

27. Renal insufficiency
2. earthy color face, pallor
1. pruritic (scratch marks), dry skin

28. 3. nail changes 4. xerosis cutis

29. 5. calciphylaxis 6. uremic frost

31. Diabetes Mellitus

32. Acanthosis nigricans

33. LJM and scleroderma-like syndrome
➢AKA cheiroarthropathy prayer sign

34. Sclerederma diabeticorum
NECROBIOSIS LIPOIDICA

35. Granuloma annulare
Diabetic dermatopathy

36. Diabetic food ulcer

37. Cushing syndrome

38. Hyper-thyroidism

39. Hypo-thyroidism

40. Addison disease

42. Liver diseases