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SCLERA
Dr. VIVEKANAND.U
ANATOMY
• Stroma (Collagen
Bundles)
• Three Vascular Layers
– Conjunctiva Vessels
– Superficial Episcleral
Vessels
– Deep Vascular
Plexus
EPISCERITIS
• Inflammatory condition affecting the
episcleral tissue that lies between the
conjunctiva and the sclera.
• Mild, self-limiting, recurrent disease.
• Most cases are idiopathic
• 1/3 = underlying systemic condition.
CLINICAL TYPES
SIMPLE
EPISCLERITIS
NODULAR
SECTORAL DIFFUSE
SIMPLE EPISCLERITIS
• SECTORAL • DIFFUSE
NODULAR EPISCLERITS
TREATMENT
• TOPICAL STEROIDS
• NSAIDs
SCLERITIS
• Scleritis is a chronic, painful, and
potentially blinding inflammatory
disease that is characterized by edema
and cellular infiltration of the scleral and
episcleral tissues.
SCLERITIS
• Peak incidence: fifth decade
• Women are more likely to have scleritis
than men (1.6:1)
SYMPTOMS AND SIGNS
• Pain
• Tearing or photophobia
• Tenderness
• Decreased visual acuity
• Primary sign is redness
• Pain is the most common symptom
• The following pain descriptions are
characteristic of scleritis:
– Severe, penetrating pain that radiates to
the forehead, brow, jaw, or sinuses
– Awakens the patient during the night
– Exacerbated by touch; extremely tender
– Only temporarily relieved by analgesics
• Past medical and ocular histories
(To elucidate systemic diseases, trauma,
infections,drugs, or surgical
procedures)
• Past and present therapies and
responses to these interventions should
be investigated
SCLERITS
With inflammation
Nodular
Non - necrotizing Necrotizing
Without
inflammation
Diffuse
ANTERIOR POSTERIOR
Scleromalacia
perforans
NODULAR SCLERITIS
Nodular scleritis
NECROTISING SCLERITIS
COMPLICATIONS
• Corneal:
– Acute infiltrative stromal keratitis
– Sclerosing keratitis
– Peripheral ulcerative keratitis
• Others:
– Uveitis, uveal effusion, glaucoma, hypotony,
perforation.
CORNEAL COMPLICATIONS
Acute diffuse stromal keratitis Sclerosing keratitis
Peripheral ulcerative keratitis
Scleromalacia perforans
• Seen in women with
longstanding
rheumatoid arthritis
• Yellow scleral
necrotic plaques
• Scleral thinning
• Exposure of
underlying uvea
POSTERIOR SCLERITIS
Proptosis
Ophthalmoplegia
Swelling of disc
Thickening of sclera (US/CT)
& T sign (fluid in sub-Tenon’s
space)
Subretinal exudates
Choroidal foLds
Exudative RD
Ring choroidal detachment
POSTERIOR SCLERITIS
Exudative retinal detachment Uveal effusion
Subretinal mass
Choroidal folds
ASSOCIATIONS
AUTOIMMUNE INFECTIOUS MISCELLANEOUS
Connective tissue
diseases
Vasculitic
diseases
Rh. arthritis
SLE
Ank. spondylitis
Reactive arthritis
Psoriatic arthritis
IBD
PAN
Wegener’s
granulomatosis
Behcet disease
GCA
Bacterial
Fungal
Viral
Parasitic
Atopy
Chemical
injuries
Drugs
Eg:pamidronate
INVESTIGATION
• RF, ANA, cANCA, Antiphospholipid
antibodies
• B-scan
TREATMENT
• TOPICAL STEROIDS
• SYSTEMIC NASAIDs
• SYSTEMIC STEROIDS
• CYTOTOXIC AGENTS (Eg. Azt.,
mtx)
• IMMUNE MODULATORS
(cyclosporin)
SCLERAL DISCOLORATION
• FOCAL
– Brown black
• Alcaptonuria
– Rusty brown
• Haemochromatosis
– Blue grey
• Minocycline
• DIFFUSE
– Yellow
• Jaundice
– Blue
• Osteogenesis
imperfecta
• Turner syndrome
• Psuedoxanthoma
elasticum

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SCLERA.ppt