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Ders gastritis
- 1. Gastritis and Peptic Ulcer Disease Hakan Şentürk
- 2. Gastritis/Gastropathy • Helicobacter pylori associated gastritis. Type B • Autoimmune gastritis-Atrophic gastritis Type A • Eosinophilic gastritis • Bile acid gastropathy • Portal-hypertensive gastropathy
- 3. Helicobacter pylori gastritis • HP is present in 70-85 % of Turkish population. • HP colonization of gastric mucosa may be totally asymptomatic. • However if dyspeptic symptoms are present, its eradication is effective. • It should be eradicated in all patient with NSAID use. • It may lead to atrophic gastritis. • It may lead to gastric cancer in a very low minority of HP infected patients. • However 90 % of gastric cancers result from HP infection.
- 4. Autoimmune Gastritis • Parietal hücrelere karşı antikorlar. • Hipoasidite ve hipergastrinemi • Intestinal metaplazi • Megaloblastic anemi (Intrinsic factor deficiency-related) • It may lead to dysplasia and gastric cancer. • Atrophic gastritis may happen in the setting of HP infection and after GA develops, HP may not be found in biopsy specimens.
- 5. Bile acid gastropathy • It is most common in subjects with gastric resection and gastroenterostomy; Cholecystectomy; Gallbladder stone. • However it may happen without these conditions. • It is called as duodeno-gastric reflux (DGR) as well. • Characterized by bile acid damage to gastric mucosa • Symptoms are the same with any type of gastritis • Difficult-to-treat condition
- 6. PEPTIC ULCER DİSEASE • Peptic ulcers mainly present in duodenal bulb and gastric body and antrum • The etiology is mostly chronic helicobacter pylori infection • The frequency is increases with non-steroidal anti-inflammatory drug (NSAID) use. • It may be related to aspirin use as well. • Sometimes malignant ulcers may be confused with benign peptic ulcers in stomach. In this case biopsy is necessary. • They may spontaneously heal. • They may result with complications
- 7. Complications of Peptic Ulcer Disease • Bleeding • Perforation • Pyloric stenosis • Penetration to pancreas