Fluidodynamics
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Meccanica dei fluidi: pressione, legge di Stevino e legge di Pascal, pressa idraulica, manometro di Torricelli, spinta di Archimede, condizioni di galleggiamento; fluidodinamica, regimi di flusso, flusso laminare e turbolento, equazione di continuità e portata, equazione di Bernoulli, cuore e sistema circolatorio, aneurisma e stenosi; viscosità, forze coesive ed adesive, idrofobicità ed angolo di contatto, viscosità e forze frenanti, gel elettroforesi, centrifugazione, cenni su microfluidica e lab on chip Fluidodynamics: pression, Stevino law, Pascal law, hydraylic press, Torricelli experiment, Archimede principle and buoyant force, condition for floating; fluidodynamics, flow regimes, laminar and turbolent regime, continuity equation, Bernoulli principle, heart and circulatory system, acute coronary syndrome and cerebral aneurysm; viscosity, cohesive and adhesive forces, hydrophobicity and contact angle, viscosity, gel electrophoresis, centrifugation, microfluidics and lab on chip research
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Fluidodynamics
- 1. group Giuseppe Maruccio giuseppe.maruccio@unisalento.it Giuseppe Maruccio Omnics Research Group Dip. di Matematica e Fisica, Università del Salento, CNR NANOTEC - Institute of Nanotechnology Via per Arnesano, 73100, Lecce (Italy) Fluidodynamics (Tecnologia dei Bioprocessi Fisica sperimentale per le Biotecnologie)
- 2. giuseppe.maruccio@unisalento.it Short Note for the readers My slides are not original at all! I prepared these presentations also employing material/images/slides/videos from books, presentations found on the web and youtube too. In case I lost some reference, first of all my apologizes to the authors and please inform me in order to correctly acknowledge them.
- 5. giuseppe.maruccio@unisalento.it Legge di Stevino e Legge di Pascal
- 6. giuseppe.maruccio@unisalento.it Pressa idraulica Application of Pascal Law Joseph Bramah designed the hydraulic press in 1795
- 7. giuseppe.maruccio@unisalento.it Construction and working of hydraulic press
- 8. giuseppe.maruccio@unisalento.it How to Make Powerful Hydraulic Press
- 11. giuseppe.maruccio@unisalento.it Science - Archimedes' Principle
- 15. giuseppe.maruccio@unisalento.it Diving the Icy Blue Waters of Antarctica for Blue Planet II - Hugh Miller E le navi ? Come fanno a galleggiare ?
- 17. giuseppe.maruccio@unisalento.it Archimede ed il problema della corona https://www.youtube.com/ watch?v=sw66gzBD9fE
- 18. giuseppe.maruccio@unisalento.it Meccanica dei Fluidi 𝐴1 𝑣1 = 𝐴2 𝑣2=cost.Equazione di continuità Pressione 𝑃 = 𝐹 𝑁 𝐴 1Pa = 1N/m2, 1 atm = 1.013 x 105 Pa = 760 Torr Variazione Pressione con profondità 𝑃 = 𝑃0 + 𝜌𝑔ℎ Spinta di Archimede 𝐵 = 𝜌 𝑓𝑙𝑢𝑖𝑑𝑜 𝑔 𝑉𝑠𝑝𝑜𝑠𝑡𝑎𝑡𝑜 Condizione galleggiamento 𝜌𝑐𝑜𝑟𝑝𝑜 < 𝜌 𝑓𝑙𝑢𝑖𝑑𝑜 𝜌 = 𝑚 𝑉 Densità 𝑃 + 1 2 𝜌𝑣2 + 𝜌𝑔𝑦 = cost.Equazione di Bernoulli
- 21. giuseppe.maruccio@unisalento.it Regime laminare e turbolento
- 24. giuseppe.maruccio@unisalento.it Bernoulli's principle 3d animation
- 25. giuseppe.maruccio@unisalento.it The Heart and Circulatory System - How They Work
- 26. giuseppe.maruccio@unisalento.it Acute Coronary Syndrome and Heart Attack
- 29. giuseppe.maruccio@unisalento.it What is Viscosity? (in one minute!) Viscosity is the resistance of a fluid to flow molecules experience friction due to molecular interactions among them larger viscosity larger force required to induce movement key for process involving fluid flow
- 30. giuseppe.maruccio@unisalento.it Viscosity, Cohesive and Adhesive Forces
- 32. giuseppe.maruccio@unisalento.it VIIa. Nanobiotechnologies Biosensors └ Basics └ Recognition └ Transduction └ Temp └ Mass └ EC └ ISFET └ Neur └ Optical └ XMR Contact angle goniometry (CAG) 1. Drop of water (other liquid) in contact with surface; 2. Angle between the film and liquid droplet measured. While CAG cannot determine the exact molecular composition, it can provide a rough estimate of both film quality and overall hydrophilic character. Measured angle reflects DEGREE OF SURFACE ORDER, and can indicate incorporation of functional groups. Ex. n-alkanethiolate SAM: contact angle slightly different from water droplet resting upon close-packed, methyl-terminated surface versus droplet resting upon disordered and thus exposed methylene tails and interior of the film. For more hydrophilic surfaces (i.e., –OH, –COOH, or –CO2CH3- terminated surfaces), the water droplet will make a smaller contact angle as the water will more effectively wet the hydrophilic surface. Conversely, a drop of a neat liquid such as hexadecane against the surface of an n-alkanethiolate SAM will have a very low contact angle, as the hydrocarbon liquid will spread across the surface of the film. Progress in Surface Science 75 (2004) 1–68 32
- 33. giuseppe.maruccio@unisalento.it VIIa. Nanobiotechnologies Biosensors └ Basics └ Recognition └ Transduction └ Temp └ Mass └ EC └ ISFET └ Neur └ Optical └ XMR Wenzel state Cassie state 33 Superhydrophobicity
- 34. giuseppe.maruccio@unisalento.it Demonstration of the Lotus Effect
- 40. giuseppe.maruccio@unisalento.it How to test the Viscosity of a Liquid
- 41. giuseppe.maruccio@unisalento.it Forze Frenanti 𝐹𝑜𝑟𝑧𝑒 𝑓𝑟𝑒𝑛𝑎𝑛𝑡𝑖 𝑅 = −𝑏 Ԧ𝑣 𝑚𝑔 − 𝑏𝑣 = 𝑚𝑎 𝑑𝑣 𝑑𝑡 = 𝑔 − 𝑏 𝑚 𝑣 = 0 𝑣𝑙𝑖𝑚𝑖𝑡𝑒 = 𝑚𝑔 𝑏 𝑣 = 𝑚𝑔 𝑏 1 − 𝑒− Τ𝑏𝑡 𝑚 = 𝑣𝑙𝑖𝑚𝑖𝑡𝑒 1 − 𝑒− Τ𝑡 𝜏 Esempio 6.8. Sfera che cade nell’olio 𝑏 = 𝑚𝑔 𝑣𝑙𝑖𝑚𝑖𝑡𝑒
- 44. giuseppe.maruccio@unisalento.it Forze Frenanti 2 𝐹𝑜𝑟𝑧𝑒 𝑓𝑟𝑒𝑛𝑎𝑛𝑡𝑖 𝑅 = 1 2 𝐷𝜌𝐴𝑣2 𝑚𝑔 − 1 2 𝐷𝜌𝐴𝑣2 = 𝑚𝑎 𝑎 = 𝑑𝑣 𝑑𝑡 = 𝑔 − 𝐷𝜌𝐴 2𝑚 𝑣2 = 0 𝑣𝑙𝑖𝑚𝑖𝑡𝑒 = 2𝑚𝑔 𝐷𝜌𝐴
- 48. giuseppe.maruccio@unisalento.it Running an Agarose Gel - University of Leicester
- 51. giuseppe.maruccio@unisalento.it VIIb. Nanobiotechnologies Microfluidics └ Introd. └ Theory └ Components/Applications Esempi What is the regime in a μ-fluidic device? 51
- 52. giuseppe.maruccio@unisalento.it VIIb. Nanobiotechnologies Microfluidics └ Introd. └ Theory └ Components/Applications Effects of the micro-domain: laminar flow 52
- 53. giuseppe.maruccio@unisalento.it VIIb. Nanobiotechnologies Microfluidics └ Introd. └ Theory └ Components/Applications Hydrodynamic focusing 53
- 54. giuseppe.maruccio@unisalento.it VIIb. Nanobiotechnologies Microfluidics └ Introd. └ Theory └ Components/Applications Dispensing in μ-fluidic devices 54
- 55. giuseppe.maruccio@unisalento.it VIIb. Nanobiotechnologies Microfluidics └ Introd. └ Theory └ Components/Applications Dispensing in μ-fluidic devices 55
- 56. giuseppe.maruccio@unisalento.it VIIb. Nanobiotechnologies Microfluidics └ Introd. └ Theory └ Components/Applications Droplet Microfluidics 56
- 57. group Giuseppe Maruccio giuseppe.maruccio@unisalento.it Organ-on-chip X.Lin et al, Anal. Methods, 2018, 10, 3122–3130
- 59. group Giuseppe Maruccio giuseppe.maruccio@unisalento.it Liquid Biopsies – Tumor Circulome Z. Qi et al., J Cancer 2018; 9(18):3417-3426, doi:10.7150/jca.24591 G. De Rubis et al, Trends in Pharmacological Sciences, 2019 doi.org/10.1016/j.tips.2019.01.006