Bioinformatics

1. BIOINFORMATICS
Presented by – Faizan Ahmed Hilal
B.S, M.S Bioinformatics

2. Bioinformatics at Glance
 A computational approach to solve the biological problems
 Bioinformatics developed a new thought, to maintain the concepts and store the huge
amount of biological data
 Logical and technical means by which not only solve the biological problems but also can
predict the new aspects

3. Bioinformatics Areas
BIOINFORMATICS
GENOMICS
PROGRAMMING
PROTEOMICS
BIOSTATISTICS
COMPUTATIONAL
BIOLOGY
CHEMINFORMATICS
DBMS
SYSTEMATIC BIOLOGY

4. Bioinformatics and Internet
 Internet plays an important role to retrieve the biological information
 The Computational Part of bioinformatics use to optimize the biological problems like
(metabolic disorder, genetic disorder)
 Computatuional part contains:
Computer
Science
Operating System
Windows/Linux/mac
Tools Application
Software Development
Database Development

5. Maths in Bioinformatics
 The Mathematical portion helps to understand the algorithm used in
bioinformatics software and tools.
 The mathematical portion which is used in bioinformatics
Mathematics
Matrices
(Sequence alignement, blast
fasta, MSA & Phylogenetic
Prediction)
Complex Mathematics
Function(Fourier
Transformation)
Biostatistics(HMM,ANN in
secondary prediction)
Differentiation
Intigration(Time and Space
complexity E-value, p-value in
blast)

6. Bioinformatics Resources
Database Search Engine
NCBI/Swiss-Prot/ Uni-prot-k
Online sever tools
Clustal-W/ Swiss- Model Server
Relational Database management
System
Other Software & Information
Sources
Online Databases
KEGG/ModBase/PDB/Zinc
databasemolsoft
Biological Databases
Primary/ Secondary/ Composite
Bioinformatics Software’s
Application
Bioinformatics Software
Development

7. Biological Databases
Types of databases
 Bibliograhic databases
 Taxonomic databases
 Nucleic acid databases
 Genomic databases
 Protein databases
 Enzyme/metabolic pathways
Information Contain
 Literature
 Classification
 DNA information
 Gene level information
 Protein information
 Metabolic pathways

8. Types of biological Databases Available
 Primary databases
 Secondary databses
 Composite Databases
Primary
Database(Nucleic
Acid/ Protein)
EMBL
Genbank
DDBJ
SWISS-
PROT
TREMB
L
PIR

9. Secondary & Composite
Secondary databases
 PROSITE
 Pfam
 BLOCKS
 PRINTS
 InterPro
 UniProt
Composite databases
 NRDB
 OWL

10. Career Prospectives in Bioinformatics
 Scientist, Research Associate, Project Associate
 Prof, Reader, & Lect in UNIV/COLLEGES
 Technical Executive in Business & Development
 Data Analyst in Scientific org & labs
 Biosoft Developer/ Tester in IT Industry
 Programmers in Pharma & Biotech Companies