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My essential tips & tricks
for success in antegrade approach
Jan-Malte Sinning, MD, FESC
St. Vincent Hospital Cologne
Potential Conflicts of Interest
Receipt of grants / research support:
Boston Scientific, Edwards Lifesciences, and Medtronic.
Proctor:
Medtronic and Boston Scientific.
Scientific Advisory Board:
Abbott, Abiomed, Boston Scientific, Boehringer Ingelheim, and Medtronic.
Receipt of speaker honoraria and/or travel expenses:
Abbott, Abiomed, Astra Zeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Bristol
Myers Squibb, Edwards Lifesciences, Medtronic, Novartis, Novo Nordisk, Pfizer, Shockwave
Medical, and Zoll.
76 years old patient with dyspnea NYHA III
Rationales for CTO Recanalization
• Relief of angina/ischemia (typically exertional symptoms)
• Improvement of ventricular function
• Reduced incidence of late CABG
• Possible improvement in event-free survival
✅
✅
✅
Four options for crossing CTOs
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
AWE
ADR
RDR
RWE
Hybrid algorithm combining antegrade and retrograde skills
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Global CTO Crossing Algorithm
Wu EB et al., JACC 2021;78:840-853
J-CTO Score predicts lesion complexity and success rate
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
My Essential Tips & Tricks for
Success in Antegrade CTO PCI
Tips & Tricks 1 – Vascular Access
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 1 – Vascular Access
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 1 – Vascular Access
Tips & Tricks 2 – Guiding catheters
LCA RCA
Tips & Tricks 2 – Guiding catheters
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 2 – Guiding catheters & extensions
Tips & Tricks 3 – Guidewire selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 3 – Guidewire selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 3 – Guidewire selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 3 – Guidewire selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 3 – Guidewire selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 3 – Guidewire selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 4 – Microcatheter selection
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 5 – Antegrade Wire Escalation (AWE)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 5 – Antegrade Wire Escalation (AWE)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Fielder XT
Gladius MG
Gaia II / III
Hornet 14
My Algorithm
Tips & Tricks 5 – Antegrade Wire Escalation (AWE)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 5 – Antegrade Wire Escalation (AWE)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Stay intra-plaque (= true lumen) !
Tips & Tricks 5 – Antegrade Wire Escalation (AWE)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 5 – Antegrade Wire Escalation (AWE)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 5 – Antegrade Wire Escalation (AWE)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
76 years old patient with dyspnea NYHA III
Bifemoral (5F, 7F), AWE via Caravel 135: Fielder XT, Gaia 2nd
Dual injections are essential
Antegrade crossing with Gaia 2nd
- Wire position in distal LAD ?
- True to true crossing ?
- Diagonal branches ?
- Lesion preparation necessary?
Tips & Tricks 6 – Intravascular Imaging
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
IVUS interpretation: 4 steps to success
Step 1: Evaluation of lesion significance / wire position
Step 1: Evaluation of lesion significance / wire position
Step 2: Characterization of lesion
Step 2: Characterization of lesion
Step 3: Evaluation of vessel diameter & lesion length
Step 3: Evaluation of vessel diameter & lesion length
Step 4: Assessment of implantation quality
Step 4: Assessment of implantation quality
Step 1: Evaluation of lesion significance
Step 1: Evaluation of lesion significance Step 2: Characterization of lesion
Step 2: Characterization of lesion
True lumen
Severe calcification 270°
False lumen
True
False
True lumen
LAD
D1
Circular calcification
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 7 – Antegrade Dissection Reentry (ADR)
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 8 - Lesion Preparation & plaque modification
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
RotaPRO® Rotational Atherectomy System
1.25 mm
1.5mm 1.75mm
2.0mm
Sharma SK et al., Circ Cardiovasc Interv. 2019;12:e007448
Rotational atherectomy with RotaPro 1.50 burr
High pressure PTCA (24atm) with NC-Balloon 3.0/15.0, 3.5/15.0 mm
Step 3: Evaluation of vessel diameter & lesion length
Step 3: Evaluation of vessel diameter & lesion length
3.0mm
4.0mm
51.0mm
Tips & Tricks 9 - Stenting
PCI with Promus 3.5/38.0mm, 3.0/16.0mm plus POT 4.0/15.0mm
Step 4: Assessment of implantation quality
Step 4: Assessment of implantation quality
No dissection
Circular stent expansion
Good strut apposition
Left main OK !
Tips & Tricks 10 – Intraprocedural Management
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 10 – Intraprocedural Management
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
Tips & Tricks 10 – Intraprocedural Management
James Spratt et al. eBook „A guide
to mastering antegrade CTO PCI“
My essential Tips & Tricks for success in antegrade CTO PCI
1. Safe vascular access (fluoroscopy or sonography guidance)
2. Guiding catheter strategy
3. Dedicated CTO wires
4. Microcatheter selection according to strategy
5. AWE (Fielder XT, Gaia II / III, Hornet 14), parallel wiring
6. Liberal use of IVUS
7. Know ADR techniques
8. Lesion preparation (rotational / orbital atherectomy, IVL, etc.)
9. Stenting optimized by intravascular imaging
10. Intraprocedural management (ACT, conscious sedation, echo etc.)
Thank you very much for your attention !
Jan-Malte.Sinning@cellitinnen.de

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Jan Malte Sinning: Keynote: My essential tips & tricks for success in antegrade approach

  • 1. My essential tips & tricks for success in antegrade approach Jan-Malte Sinning, MD, FESC St. Vincent Hospital Cologne
  • 2. Potential Conflicts of Interest Receipt of grants / research support: Boston Scientific, Edwards Lifesciences, and Medtronic. Proctor: Medtronic and Boston Scientific. Scientific Advisory Board: Abbott, Abiomed, Boston Scientific, Boehringer Ingelheim, and Medtronic. Receipt of speaker honoraria and/or travel expenses: Abbott, Abiomed, Astra Zeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Bristol Myers Squibb, Edwards Lifesciences, Medtronic, Novartis, Novo Nordisk, Pfizer, Shockwave Medical, and Zoll.
  • 3. 76 years old patient with dyspnea NYHA III
  • 4. Rationales for CTO Recanalization • Relief of angina/ischemia (typically exertional symptoms) • Improvement of ventricular function • Reduced incidence of late CABG • Possible improvement in event-free survival ✅ ✅ ✅
  • 5. Four options for crossing CTOs James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“ AWE ADR RDR RWE
  • 6. Hybrid algorithm combining antegrade and retrograde skills James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 7. Global CTO Crossing Algorithm Wu EB et al., JACC 2021;78:840-853
  • 8. J-CTO Score predicts lesion complexity and success rate James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 9. My Essential Tips & Tricks for Success in Antegrade CTO PCI
  • 10. Tips & Tricks 1 – Vascular Access James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 11. Tips & Tricks 1 – Vascular Access James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 12. Tips & Tricks 1 – Vascular Access
  • 13. Tips & Tricks 2 – Guiding catheters LCA RCA
  • 14. Tips & Tricks 2 – Guiding catheters James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 15. Tips & Tricks 2 – Guiding catheters & extensions
  • 16. Tips & Tricks 3 – Guidewire selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 17. Tips & Tricks 3 – Guidewire selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 18. Tips & Tricks 3 – Guidewire selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 19. Tips & Tricks 3 – Guidewire selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 20. Tips & Tricks 3 – Guidewire selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 21. Tips & Tricks 3 – Guidewire selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 22. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 23. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 24. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 25. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 26. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 27. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 28. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 29. Tips & Tricks 4 – Microcatheter selection James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 30. Tips & Tricks 5 – Antegrade Wire Escalation (AWE) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 31. Tips & Tricks 5 – Antegrade Wire Escalation (AWE) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“ Fielder XT Gladius MG Gaia II / III Hornet 14 My Algorithm
  • 32. Tips & Tricks 5 – Antegrade Wire Escalation (AWE) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 33. Tips & Tricks 5 – Antegrade Wire Escalation (AWE) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“ Stay intra-plaque (= true lumen) !
  • 34. Tips & Tricks 5 – Antegrade Wire Escalation (AWE) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 35. Tips & Tricks 5 – Antegrade Wire Escalation (AWE) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 36. Tips & Tricks 5 – Antegrade Wire Escalation (AWE) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 37. 76 years old patient with dyspnea NYHA III
  • 38. Bifemoral (5F, 7F), AWE via Caravel 135: Fielder XT, Gaia 2nd
  • 39. Dual injections are essential
  • 40. Antegrade crossing with Gaia 2nd - Wire position in distal LAD ? - True to true crossing ? - Diagonal branches ? - Lesion preparation necessary?
  • 41. Tips & Tricks 6 – Intravascular Imaging James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 42. IVUS interpretation: 4 steps to success Step 1: Evaluation of lesion significance / wire position Step 1: Evaluation of lesion significance / wire position Step 2: Characterization of lesion Step 2: Characterization of lesion Step 3: Evaluation of vessel diameter & lesion length Step 3: Evaluation of vessel diameter & lesion length Step 4: Assessment of implantation quality Step 4: Assessment of implantation quality
  • 43. Step 1: Evaluation of lesion significance Step 1: Evaluation of lesion significance Step 2: Characterization of lesion Step 2: Characterization of lesion True lumen Severe calcification 270° False lumen True False True lumen LAD D1 Circular calcification
  • 44. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 45. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 46. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 47. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 48. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 49. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 50. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 51. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 52. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 53. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 54. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 55. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 56. Tips & Tricks 7 – Antegrade Dissection Reentry (ADR) James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 57. Tips & Tricks 8 - Lesion Preparation & plaque modification James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 58. RotaPRO® Rotational Atherectomy System 1.25 mm 1.5mm 1.75mm 2.0mm Sharma SK et al., Circ Cardiovasc Interv. 2019;12:e007448
  • 59. Rotational atherectomy with RotaPro 1.50 burr
  • 60. High pressure PTCA (24atm) with NC-Balloon 3.0/15.0, 3.5/15.0 mm
  • 61. Step 3: Evaluation of vessel diameter & lesion length Step 3: Evaluation of vessel diameter & lesion length 3.0mm 4.0mm 51.0mm Tips & Tricks 9 - Stenting
  • 62. PCI with Promus 3.5/38.0mm, 3.0/16.0mm plus POT 4.0/15.0mm
  • 63. Step 4: Assessment of implantation quality Step 4: Assessment of implantation quality No dissection Circular stent expansion Good strut apposition Left main OK !
  • 64. Tips & Tricks 10 – Intraprocedural Management James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 65. Tips & Tricks 10 – Intraprocedural Management James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 66. Tips & Tricks 10 – Intraprocedural Management James Spratt et al. eBook „A guide to mastering antegrade CTO PCI“
  • 67. My essential Tips & Tricks for success in antegrade CTO PCI 1. Safe vascular access (fluoroscopy or sonography guidance) 2. Guiding catheter strategy 3. Dedicated CTO wires 4. Microcatheter selection according to strategy 5. AWE (Fielder XT, Gaia II / III, Hornet 14), parallel wiring 6. Liberal use of IVUS 7. Know ADR techniques 8. Lesion preparation (rotational / orbital atherectomy, IVL, etc.) 9. Stenting optimized by intravascular imaging 10. Intraprocedural management (ACT, conscious sedation, echo etc.)
  • 68. Thank you very much for your attention ! Jan-Malte.Sinning@cellitinnen.de