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innovative approaches to research and


CIC bioGUNE                                                                                                                                                                                                                 Prof José M Mato
                                                                                                                                                                                                                            General Director
                                                                                                                                                                                                                                                   technological innovation. Following this
                                                                                                                                                                                                                                                   concept, the Center has set up three joint
                                                                                                                                                                                                                                                   research laboratories with companies
                                                                                                                                                                                                                                                   established in the Basque Country.                 “THE WORLD LOOKS SO DIFFERENT AFTER LEARNING SCIENCE”


PLAYS A STRONG ROLE                                                                                                                                                                                                                                External funding represents a critical
                                                                                                                                                                                                                                                   component of CIC bioGUNE’s strategic plan.
                                                                                                                                                                                                                                                   Since 2006, CIC bioGUNE has received
                                                                                                                                                                                                                                                                                                      Richard Feynman




IN ADVANCING                                                                                                                                                                                   CIC bioGUNE invested over 35 million €
                                                                                                                                                                                               in state-of-the-art research infrastructures,
                                                                                                                                                                                               including genomics, gene silencing,
                                                                                                                                                                                               proteomics, metabolomics, NMR, electron
                                                                                                                                                                                                                                                   4.1 million € from competitive research grants
                                                                                                                                                                                                                                                   (mainly from the European Union, NIH, the
                                                                                                                                                                                                                                                   Spanish Plan Nacional I+D+I, FIS, CIBER and
                                                                                                                                                                                                                                                   CONSOLIDER programs) and 1 million € from


BIOMEDICAL RESEARCH                                                                                                                              CIC bioGUNE research strategy resides in
                                                                                                                                                the firm belief that if talented researchers
                                                                                                                                                     are given the freedom and necessary
                                                                                                                                                means they will contribute to the solution
                                                                                                                                                                                               microscopy, x-ray diffraction, computer and
                                                                                                                                                                                               animal facilities, to support the research
                                                                                                                                                                                               activities of its faculty and students.
                                                                                                                                                                                               The Center commits every year more than
                                                                                                                                                                                                                                                   foundations (primarily from the BBVA
                                                                                                                                                                                                                                                   Foundation and Genome Spain) and research
                                                                                                                                                                                                                                                   contracts. Concerted efforts of the
                                                                                                                                                                                                                                                   administration of CIC bioGUNE have helped


AND TECHNOLOGICAL                                                                                                                                of the fundamental biological questions.      5.5 million € for research and dedicates 450
                                                                                                                                                                                               thousand € to PhD training. It employs 22
                                                                                                                                                                                               faculty investigators, more than 85 postdocs,
                                                                                                                                                                                               technicians and engineers, and provides
                                                                                                                                                                                                                                                   the faculty to succeed in the competition for
                                                                                                                                                                                                                                                   external funding. Extramural funding,
                                                                                                                                                                                                                                                   combined with the generous support of the
                                                                                                                                                                                                                                                   Basque Government and the Regional



INNOVATION IN                                                                                                                                                                                  training opportunities to more than 23 PhD
                                                                                                                                                                                               students each year. Our 22 faculty investigators,
                                                                                                                                                                                               recruited internationally, include 15 fellows
                                                                                                                                                                                               from Ikerbasque, Bizkaia:xede, and Ramón y
                                                                                                                                                                                                                                                   Government of Bizkaia, allowed faculty
                                                                                                                                                                                                                                                   research projects to grow and prosper.
                                                                                                                                                                                                                                                   In fact, in 2008 CIC bioGUNE’s investigators
                                                                                                                                                                                                                                                   authored 51 scientific publications, in journals



THE BASQUE COUNTRY
                                                                                                                                                                                               Cajal programs.                                     with an average impact factor of 7, and
                                                                                                                                                                                                                                                   applied for 3 international patents.
                                                                                                                                                                                               CIC bioGUNE research strategy is based on
                                                                                                                                                                                               the firm belief that if talented researchers are    CIC bioGUNE collaborates with the University
                                                                                                                                                                                               given the freedom and necessary means               of the Basque Country in the Master of
                                                                                                                                                                                               they will contribute to the solution of the         Molecular Biology and Biomedicine
        The conviction that fundamental     We live in a time of discovery. Every year, new   research and technological innovation can                                                        fundamental biological questions. Following         programme, reflecting our commitment to
   biomedical research and technological    discoveries bring us closer to answering of       be brought together drives our work at                                                           this policy, scientists at CIC bioGUNE have         inspire and educate a new generation of
innovation can be brought together drives   the crucial questions about life; improved        the Center for Cooperative Research in                                                           established research projects in a variety of       scientists. The Center also combines the
   our work at the Center for Cooperative   understanding and treatment of disease have       Biosciences, CIC bioGUNE.                                                                        areas, including cell growth and                    organization of research seminars, workshops,
    Research in Biosciences, CIC bioGUNE.   never been so tantalizingly close. At the same                                                                                                     differentiation, cancer, the innate immune          and congresses directed to specialists with
                                            time, science and technology have become          CIC bioGUNE, a non-profit biomedical research                                                    response, liver disease, chromatin                  series of lectures designed for the general
                                            global and it is undeniable that scientific       organization founded in 2002 by the Department                                                   remodeling, intracellular trafficking processes,    public. CIC bioGUNE, in collaboration with
                                            knowledge plays a fundamental role in the         of Industry of the Basque Government, opened                                                     and the structure of proteins, ribosomes and        the other CIC, publishes CIC Network, a
                                            generation of wealth. However, not all            its research installations at the Technology                                                     viruses. The projects are summarized in this        journal dedicated to promote a culture of
                                            countries know how to obtain the best             Park of Bizkaia in January 2005. Since then,                                                     annual report. We also firmly believe in            research and technological innovation in the
                                            socioeconomic benefit from this common            CIC bioGUNE has played a strong role in                                                          the necessity of creating a lively intellectual     Basque Country.
                                            knowledge (the so-called European paradox).       advancing biomedical research and                                                                environment in collaboration with biotech
                                            The conviction that fundamental biomedical        technological innovation in the Basque Country.                                                  companies that fosters creative and

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Introduction Prof. Jose M. Mato

  • 1. innovative approaches to research and CIC bioGUNE Prof José M Mato General Director technological innovation. Following this concept, the Center has set up three joint research laboratories with companies established in the Basque Country. “THE WORLD LOOKS SO DIFFERENT AFTER LEARNING SCIENCE” PLAYS A STRONG ROLE External funding represents a critical component of CIC bioGUNE’s strategic plan. Since 2006, CIC bioGUNE has received Richard Feynman IN ADVANCING CIC bioGUNE invested over 35 million € in state-of-the-art research infrastructures, including genomics, gene silencing, proteomics, metabolomics, NMR, electron 4.1 million € from competitive research grants (mainly from the European Union, NIH, the Spanish Plan Nacional I+D+I, FIS, CIBER and CONSOLIDER programs) and 1 million € from BIOMEDICAL RESEARCH CIC bioGUNE research strategy resides in the firm belief that if talented researchers are given the freedom and necessary means they will contribute to the solution microscopy, x-ray diffraction, computer and animal facilities, to support the research activities of its faculty and students. The Center commits every year more than foundations (primarily from the BBVA Foundation and Genome Spain) and research contracts. Concerted efforts of the administration of CIC bioGUNE have helped AND TECHNOLOGICAL of the fundamental biological questions. 5.5 million € for research and dedicates 450 thousand € to PhD training. It employs 22 faculty investigators, more than 85 postdocs, technicians and engineers, and provides the faculty to succeed in the competition for external funding. Extramural funding, combined with the generous support of the Basque Government and the Regional INNOVATION IN training opportunities to more than 23 PhD students each year. Our 22 faculty investigators, recruited internationally, include 15 fellows from Ikerbasque, Bizkaia:xede, and Ramón y Government of Bizkaia, allowed faculty research projects to grow and prosper. In fact, in 2008 CIC bioGUNE’s investigators authored 51 scientific publications, in journals THE BASQUE COUNTRY Cajal programs. with an average impact factor of 7, and applied for 3 international patents. CIC bioGUNE research strategy is based on the firm belief that if talented researchers are CIC bioGUNE collaborates with the University given the freedom and necessary means of the Basque Country in the Master of they will contribute to the solution of the Molecular Biology and Biomedicine The conviction that fundamental We live in a time of discovery. Every year, new research and technological innovation can fundamental biological questions. Following programme, reflecting our commitment to biomedical research and technological discoveries bring us closer to answering of be brought together drives our work at this policy, scientists at CIC bioGUNE have inspire and educate a new generation of innovation can be brought together drives the crucial questions about life; improved the Center for Cooperative Research in established research projects in a variety of scientists. The Center also combines the our work at the Center for Cooperative understanding and treatment of disease have Biosciences, CIC bioGUNE. areas, including cell growth and organization of research seminars, workshops, Research in Biosciences, CIC bioGUNE. never been so tantalizingly close. At the same differentiation, cancer, the innate immune and congresses directed to specialists with time, science and technology have become CIC bioGUNE, a non-profit biomedical research response, liver disease, chromatin series of lectures designed for the general global and it is undeniable that scientific organization founded in 2002 by the Department remodeling, intracellular trafficking processes, public. CIC bioGUNE, in collaboration with knowledge plays a fundamental role in the of Industry of the Basque Government, opened and the structure of proteins, ribosomes and the other CIC, publishes CIC Network, a generation of wealth. However, not all its research installations at the Technology viruses. The projects are summarized in this journal dedicated to promote a culture of countries know how to obtain the best Park of Bizkaia in January 2005. Since then, annual report. We also firmly believe in research and technological innovation in the socioeconomic benefit from this common CIC bioGUNE has played a strong role in the necessity of creating a lively intellectual Basque Country. knowledge (the so-called European paradox). advancing biomedical research and environment in collaboration with biotech The conviction that fundamental biomedical technological innovation in the Basque Country. companies that fosters creative and