EuroBioForum 2013 - Day 2 | Menno Kok

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EuroBioForum 2013 2nd Annual Conference
27-28 May 2013 - Hilton Munich City, Munich, Germany
http://www.eurobioforum.eu/2013

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# REGIONAL PERSPECTIVES #

Rotterdam Delta, The Netherlands:
What’s keeping medicine from becoming personalised?

Dr Menno Kok,
Advisor Research Strategies Erasmus MC and sector manager Medical Delta

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http://www.eurobioforum.eu

Published in: Health & Medicine, Business
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EuroBioForum 2013 - Day 2 | Menno Kok

  1. 1. 27-28 May 2013, Munich, GermanyEuroBioForum 2013 2nd Annual ConferenceWhat’s keeping medicine…from becoming personalized?Menno Kok
  2. 2. • Appr. 14.000 employees, of which > 1500 medical and scientific staff• > 40.000 patients admitted• > 500.000 visits to outpatient clinics• 27,700 operations (incl. day treatment)• Appr. 3000 medical students• 28 medical specialty training courses• > 1000 PhD students• > 400 transplantations/y• 400-450 new clinical trials/y• Budget € 1.3 billionErasmus University Medical Center, Rotterdam
  3. 3. Top Reference and Top Clinical Care:Cardio-Vascular (Thorax Centre)Clinical GeneticsGastero-EnterologyInfectious Diseases, VirologyOncology (Daniel den Hoed Clinic)Pediatrics (Sophia Children’s Hospital)Transplantation (Liver, Kidney, Heart,Lung, Bone Marrow)TraumatologyResearch:CardiovascularOncologyCell Biology & GeneticsImmunology & HaematologyNeurosciencesPediatricsMedical Technology/ImagingEpidemiology and Public HealthHealth Policy and Management*Erasmus University Medical Center, Rotterdam
  4. 4. Personalized MedicinePersonalized medicine generates and uses all the relevant informationavailable on the individual patient to make informed choices betweentreatment options and fine-tune these subsequently.Main activities of Erasmus MC:- Cancer (breast, colon, lung, prostate, skin, brain, leukemia);- Cardiovascular dis.;- Medical Informatics (phase IV); Bio-informatics- Imaging, -omics- HTACollaborative efforts:- All strategic research in national and mostly international collaboration;- Epidemiological research (coupled cohorts);- String of pearls 8  13 disease area’s, connection to electronic patient files.
  5. 5. Personalized MedicinePersonalized medicine generates and uses all the relevant informationavailable on the individual patient to make informed choices betweentreatment options and fine-tune these subsequently.is it really all about genetics?
  6. 6. Personalized MedicineGenetic variationEpigenetic variationAge (life stage)Food intakeCircadian clockStressImpaired organ functionOther confounding conditionsBody sizeMicrobiomePrevious exposurePhysical and mental activity
  7. 7. FunctionPersonalized HealthLife phase: I II III IV
  8. 8. FunctionAnnual costPersonalized HealthInclusion inclinical trialsLife phase: I II III IV
  9. 9. Personalized HealthPersonalized Health generates and uses all the relevant informationavailable on the individual citizen to provide him/her with advice on healthissues, life style, work-life management, physical and socio-psychologicalcapacity building and (other) preventive options.Main hurdles:At research level: evidence baseAt implementation level: reimbursement modelsAt execution level: acceptance and adherencePersonalized Medicine generates and uses all the relevant informationavailable on the individual patient to make informed choices betweentreatment options and fine-tune these subsequently.
  10. 10. Personal perspectiveEmpirical (genetic) data changes the way individuals perceive themselves andtheir families, and change the way others see them (Taylor, 2008)Self management: personalized health shifts the responsibility for good healthfrom government and collectives to the individual, who becomes responsiblefor his/her own health or disease (Savond, 2013).Patient centered medicine requires patient centered decision-making, healthliteracy, trusted information sources, and better communication to start with.
  11. 11. 1. Innovation in clinical trials;2. Develop point of care devices and technologies;3. Promote personalized health.TOP 3 recommendations:

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