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EuroBioForum2014_speaker_Balling

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EuroBioForum 3rd annual conference was held in Tallinn, Estonia, 22 + 23 September 2014

Published in: Health & Medicine
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EuroBioForum2014_speaker_Balling

  1. 1. Rudi Balling Director Luxembourg Centre for Systems Biomedicine, Luxembourg Perspective from Science
  2. 2. The Luxembourg Centre for Systems Biomedicine (LCSB)
  3. 3. Experimental Biology Technology platforms Clinical translational research Computer science & Bioinformatics Interdisciplinarity of LCSB
  4. 4. Neurodegenerative Diseases as network perturbations
  5. 5. 9/26/2014 Mathematicians Computational scientists Engineers Biologists Veterinarians Clinical Scientists Interdisciplinarity
  6. 6. Lessons learned
  7. 7. Interdisciplinarity requires Teamwork Altshuler & Altshuler, Nature 429, 479-481, 2004 „To put the success of the group over the success of the individual“
  8. 8. Proximity is important
  9. 9. Increasing communication by reciprocal delegation
  10. 10. Sharing credit in multidisciplinary teams
  11. 11. 9/26/2014 Promoting community-driven approaches Ines Thiele
  12. 12. Vol. 49, 88-102, 2014 http://pdmap.uni.lu/pd_map/ Community-driven Disease Maps
  13. 13. How to make comprehensive maps comprehensible
  14. 14. 9/26/2014 Construction of a Parkinson´s disease map
  15. 15. • Standardized knowledge repository • Standardized, quality controlled annotations • Structured Information • Visualization of large data sets • Analysis in the context of disease mechanisms • Interface to bioinformatic and modeling tools Disease maps as a community crowdsourcing tool
  16. 16. Transferring concepts from ecology to medicine
  17. 17. Can we identify early warning signals of diseases?
  18. 18. 9/26/2014 Different ways in which an ecosystem can respond to change in conditions M. Scheffer & R.S. Carpenter Trends in Ecology and Evolution 2003
  19. 19. Predicting tipping points: Early warning signals (Scheffer et al. 2009) • Coefficient of variation • Coefficient of auto-correlation • Skewness
  20. 20. 9/26/2014 (Chen et al., Scientific Relports 2012)
  21. 21. The next generation of students should learn how to look for amplifiers and logic circuits, as well as to describe and look for molecules and genes. (Hartwell et al. Nature 402, C47, 1999) Training the next generation
  22. 22. Personalized medicine is a paradigm shift

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