Vitamin C toxicity

1. Domina Petric, MD
Vitamin C
toxicity

2. Megadoses of vitamin C may:
Increase oxalate production formation of renal stones.
Competitively inhibit the renal reabsorption of uric acid.
Enhance the destruction of vitamin B12 in the gut.
Enhance the enteric absorption of nonheme iron, leading to
iron overload.
Produce mutagenic effects.
Increase ascorbate catabolism that would persist after
returning to lower intakes of the vitamin.
4/14/2018
Combs GF. The Vitamins. Fundamental Aspects
in Nutrition and Health. Elsevier Inc. 2008.
2

3. Vitamin C toxicity
The avoidance of doses
greater than 1000 mg of
vitamin C is important for
individuals with a history of
forming renal stones!
4/14/2018
Combs GF. The Vitamins. Fundamental Aspects
in Nutrition and Health. Elsevier Inc. 2008.
3

4. Vitamin C toxicity
4/14/2018
Combs GF. The Vitamins. Fundamental Aspects
in Nutrition and Health. Elsevier Inc. 2008.
4

5. • Combs GF. The Vitamins. Fundamental Aspects in
Nutrition and Health. Elsevier Inc. 2008.
Literature
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