3. Neurobiology of emotion
Emotion is associated with implicit modes
of processing.
James-Lange theory of emotion:
Emotion-provoking stimulus activates
peripheral receptors.
Smooth and striated muscle activities are
engaged.
Peripheral responses are detected.
Emotion is elicited by peripheral feedback.
https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
4. Neurobiology of emotion
Emotion can be considered as a form of
associative learning.
Emotions result from association of
sensory stimuli with primary reinforcers.
Sensory stimuli can be interoceptive
(derived from within the body) and
exteroceptive (derived from outside the
body).
Primary reinforcers can be rewards and
punishers.https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
5. Neurobiology of emotion
Amygdala is
important for the
associative learning
and emotions.
https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
7. Limbic forebrain functional
divisions
Olfactory division (olfactory bulb and
cortex): special sensory function
(smell, flavor).
Parahippocampal division
(hippocampus, posterior hippocampal
formation, posterior cingulate gyrus,
thalamic anterior nucleus, posterior
hypothalamus): explicit processing
(episodic memory acquisition and
consolidation spatial mapping).https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
8. Limbic forebrain functional
divisions
Amygdala/orbital prefrontal division:
amygdala, orbital-medial prefrontal cortex,
anterior hippocampal formation, anterior
cingulate gyrus, temporal pole cortex,
ventral striatum, ventral pallidum, thalamic
mediodorsal nucleus, medial
hypothalamus
implicit processing (visceral motor
control, emotional experience and
expression, appetitive drives, social
behavior)
https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
9. Key brain systems for associative
learning between primary and
secondary reinforcers:
https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
10. Amygdala
Medial group of cells.
Central group of cells: output from the
amygdala to the medial part of the
hypothalamus.
Basal-lateral group of cells:
connections with the medial-orbital
prefrontal cortex (bidirectional
connections).
Basal-lateral group of cells is very
important source of inputs for the
nucleus accumbens.
https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
12. Urbach-Wiethe disease
Rare, autosomal recessive disorder that
producess bilateral calcification and
atrophy of the anterior, medial temporal
lobe.
There is bilateral destruction of amygdaloid
complex.
There is sparing of temporal neocortex and
hippocampal formation.
There are no primary sensorimotor deficits.
Patients have impaired fear recognition in
facial expressions and impaired experience
of fear.
https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
14. Amygdala functions overview
Amygdala plays a primary role in association
of sensory stimuli with reward or punishment.
Amygdala modulates information processing
in the forebrain.
Enchances awareness of aversive or arousing
stimuli.
Enchances memory for emotionally charged
events.
Amygdala hypofunction produces deficits in
the efficacy of information processing.
Amygdala hyperfunction produces excessive
vigilance and anxiety.
https://www.coursera.org/learn/medical-neuroscience: Leonard E.
White, PhD, Duke University
