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1. About Synthetic Cannabinoids
Synthetic cannabinoids are functionally similar to Δ9-tetrahydrocannabinol (THC), the
active principle of cannabis. Like THC, they bind to the same cannabinoid receptors in
the brain and other organs as the endogenous ligand anandamide. In late 2008, several
cannabinoids were detected in herbal smoking mixtures or incense. They do not
contain tobacco or cannabis but when smoked, produce effects similar to those of
cannabis (EMCDDA, 2013).
The synthetic cannabinoids fall into seven major structural groups:
Naphthoylindoles (e.g. JWH-018, JWH-073 and JWH-398).
Naphthylmethylindoles.
Naphthoylpyrroles.
Naphthylmethylindenes.
Phenylacetylindoles (i.e. benzoylindoles, e.g. JWH-250).
Cyclohexylphenols (e.g. CP 47,497 and homologues of CP 47,497).
Classical cannabinoids (e.g. HU-210).

2. Highdi’s Almdröhner
Aroma
Blue Lotus
Sky
ChillX Smoke
K2
Skunk
Moon Rocks Solar Flare
Scope
Genie Sence
Yucatan Fire
Earth Impact
Gorillaz
Galaxy Gold Space Truckin

3. JWH-167 (Phenyl)
JWH-203 (Phenyl)
JWH-250 (Phenyl)
JWH-251 (Phenyl)
JWH-320 (Phenyl)
RCS-8 (Phenyl)
Naphthoylindoles
JWH-007 (Naph)
JWH-015 (Naph)
JWH-018 (Naph)
JWH-019 (Naph)
JWH-081 (Naph)
JWH-098 (Naph)
JWH-116 (Naph)
MAM-2201
AM-2201 (Naph)
AM-1220
AM-1235
AM-2232
AM-1248 (Adam)
AB-001 (Adam)
CP 47, 497 (non-classical)
CP 55,244 (non-classical)
CP 55,940 (non-classical)
HU-308 (non-classical)
AM-2233 (benz)
RCS-4 (Benz)
AM-694 (benz)
AM-630 (benzoil)

4. AM-630 AM-679 AM-694
Research
Inverse Agonist for CB2
Ki= 32.1nM at CB2
165x fold selectivity over CB1
Research
Agonist for CB1 and CB2
Ki = 13.5nM at CB1
Ki = 49.5nM at CB2.
Designer Drug
Map CB1 Rreceptor
Selective Agonist for CB1
Ki = ? 13.5nM at CB1
AM-1241 AM-2233 RCS-4
Peripheral CB receptor
Ki= 2.1nM at CB12
100 fold selectivity over
CB1
Potent agonist
Ki = 1.8nM at CB1
Ki = 2.2nM at CB2
JWH 018 analog
Found in ‘herbal incense’ products

5. Naphthoylindoles
AM-1220 AM-1221 AM-1235
AM-2201
AM-2232 JWH-007
Research
Agonist for CB1
Ki = 3.88 nM CB1
Ki = 73.4 nM CB2
Research
Agonist for CB2
Ki = 52.4 nM CB1
Ki = 0.28 nM CB2
Research
Agonist for CB1
Ki = 1.50 nM CB1
Ki = 20.4 nM CB2
Research
Agonist
Ki = 1.0 nM CB1
Ki = 2.6 nM CB2
Research
Agonist
Ki = 0.28 nM CB1
Ki = 1.48 nM CB2
‘Herbal Synthetic’
Agonist
Ki = 9.0 nM CB1
Ki = 2.9 nM CB2

6. JWH-015 JWH-018 JWH-019
Research
Agonist for CB2
Ki = 388 nM CB1
Ki = 13.9 nM CB2
Synthetic (herbal incense)
Full Agonist
Ki = 9.00 nM CB1
Ki = 2.94 nM CB2
Synthetic (herbal incense)
Full Agonist
Ki = 9.80 nM CB1
Ki = 5.60 nM CB2
JWH-073 JWH-081 JWH-098
Synthetic analgesic
Full Agonist
Ki = 8.9 nM CB1
Ki = 38 nM CB2
Synthetic analgesic
Full Agonist
Ki = 1.20 nM CB1
Ki = 12.4 nM CB2
Research
Full Agonist
Ki = 4.50 nM CB1
Ki = 1.88 nM CB2

7. JWH-116
JWH-149
JWH-193 JWH-198
JWH-200
Research
Full Agonist
Ki = 52 nM CB1
Research
Agonist for CB2
Ki = 5.0 nM CB1
Ki = 0.73 nM CB2
Research
Agonist for CB1
Ki = 10 nM CB1
Research
Agonist for CB1
Ki = 6 nM CB1
Research
Analgesic
Agonist for CB1
IC50 = 7.8 - 42 nM

8. JWH-210 JWH-398 JWH-424
Research
Agonist
Ki = 0.46 nM CB1
Ki = 0.69 nM CB2
MAM-2201
Found in ‘Herbal Incense’
Analgesic
Agonist
Ki = 2.3 nM CB1
Ki = 2.8 nM CB2
Research
Agonist
Ki = 20.9 nM CB1
Ki = 5.40 nM CB2
Research
Agonist
Ki = 1.0 nM CB1
Ki = 2.6 nM CB2

9. CP 47,497 (cannabicyclohexanol) CP 55,940 HU-308
Agonist
Ki = 2.2 nM CB1
Analgesic
Motor depresant
Anticonvulsants
Research
Agonist
Ki = 0.58 nM CB1
Ki = 0.69 nM CB2
Research
Agonist
Ki = 10 uM CB1
Ki = 20 nM CB2
Agonist
Potent analgesic
Found in Spice Gold

10. Phenylacetylindoles
JWH-167 JWH-203 JWH-250
JWH 251
JWH-320
RCS-8
Research
Agonist
Ki = 90 nM CB1
Ki = 159 nM CB2
Research
Agonist
Ki = 8.0 nM CB1
Ki = 7.0 nM CB2
Research
Agonist
Ki = 11.0 nM CB1
Ki = 33.0 nM CB2
Synthetic Herbal

11. Adamantoylindoles
AB-001 AM-1248
Synthetic Herbal Synthetic Herbal