Intentional re-challenge refers to a deliberate and controlled re-administration of a drug to a patient who has previously experienced an adverse drug reaction (ADR) or drug-related problem (DRP). This process is conducted under close monitoring and supervision to assess whether the adverse event recurs and to gather additional clinical data related to the drug's safety profile. The clinical data management of drug-related problems, particularly during intentional re-challenge, plays a pivotal role in ensuring patient safety and informing regulatory decisions. Here's an overview of how intentional re-challenge is managed in clinical data