1. Papers:
1. Altomare Claudia, Chiara Bartolucci, Luca Sala, Marcella Rocchetti, Gaspare Mostacciuolo,
Stefano Severi and Antonio Zaza. IKr impact on repolarization and its variability assessed by
Dynamic-Clamp. Circ Arrhythm Electrophysiol. 2015 Oct;8(5):1265-75.
2. Chiara Bartolucci, Claudia Altomare, Marco Bennati, Simone Furini, Antonio Zaza and Stefano
Severi. Combined Action Potential- and Dynamic-Clamp for accurate computational modelling
of the cardiac IKr current. J Mol Cell Cardiol. 2015 Feb;79:187-94.
3. Pisano Federica PhD, Altomare Claudia, Cervio Elisabetta PhD, Barile Lucio PhD, Rocchetti
Marcella PhD, Ciuffreda Maria Chiara PhD, Malpasso Giuseppe BSc, Copes Francesco BSc,
Manuela Mura PhD, Patrizia Danieli PhD, Viarengo Gianluca MD, Zaza Antonio MD, Gnecchi
Massimiliano MD, PhD. Combination of miRNA499 and miRNA133 exerts a synergic effect on
cardiac differentiation. Stem Cells. 2015 Apr;33(4):1187-99.
4. Rocchetti M, Sala L, Rizzetto R, Staszewsky LI, Alemanni M, Zambelli V, Russo I, Barile L,
Cornaghi L, Altomare C, Ronchi C, Mostacciuolo G, Lucchetti J, Gobbi M, Latini R, Zaza A.
Ranolazine prevents INaL enhancement and blunts myocardial remodelling in a model of
pulmonary hypertension. Cardiovasc Res. 2014 Oct 1;104(1):37-48
5. Bartolucci, Chiara; Altomare, Claudia; Bennati, Marco; Furini, Simone; Zaza, Antonio; Severi,
Stefano. Combined Action Potential- and dynamic-clamp for accurate computational modeling of
the kinetics of cardiac IKr current. Computing in Cardiology Conference (CinC), 2013
Publication Year: 2013 , Page(s): 835 – 838
6. Altomare, Claudia; Sala, Luca; Bartolucci, Chiara ; Mostacciuolo, Gaspare; Severi, Stefano;
Zaza, Antonio. IKr impact on repolarization and its variability assessed by Dynamic-Clamp
Computing in Cardiology Conference (CinC), 2013 Publication Year: 2013 , Page(s): 843 - 846
7. Sala, Luca ; Hegyi, Bence ; Bartolucci, Chiara ; Altomare, Claudia ; Rocchetti, Marcella ;
Mostacciuolo, Gaspare ; Severi, Stefano ; Szentandrassy, Norbert ; Nanasi, Peter P ; Zaza,
Antonio. Effects of species-dependent differences in action potential shape in setting β-
adrenergic-stimulation induced current. Computing in Cardiology Conference (CinC), 2013
Publication Year: 2013 , Page(s): 381 – 384.
8. Altomare C, Barile L, Rocchetti M, Sala L, Crippa S, Sampaolesi M, Zaza A. Altered functional
differentiation of mesoangioblasts in a genetic myopathy. J Cell Mol Med. 2013;17:419-28.
9. Roberto Rizzi, Elisa Di Pasquale, Paola Portararo, Roberto Papait, Paola Cattaneo, Michael VG
Latronico, Claudia Altomare, Antonio Zaza, Emilio Hirsch, Luigi Naldini, Gianluigi
Condorelli, and Claudia Bearzi. (2012) Post-natal cardiomyocytes can generate iPS cells with an
enhanced capacity toward cardiomyogenic re-differentation. Cell Death Differ (2012)
Jul;19(7):1162-74
10. Crippa S, Cassano M, Messina G, Galli D, Galvez BG, Curk T, Altomare C, Ronzoni F, Toelen
J, Gijsbers R, Debyser Z, Janssens S, Zupan B, Zaza A, Cossu G, Sampaolesi M. miR669a and
miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol.
2011 Jun 27;193(7):1197-212.
11. Altomare C, Barile L, Marangoni S, Rocchetti M, Alemanni M, Mostacciuolo G, Giacomello A,
Messina E, Zaza A. Caffeine-induced Ca2+
signaling as an index of cardiac progenitor cells
differentiation. Basic Res Cardiol. 2010 Jul 23
12. Barile L, Cerisoli F, Frati G, Gaetani R, Chimenti I, Forte E, Cassinelli L, Spinardi L, Altomare
C, Kizana E, Giacomello A, Messina E, Ottolenghi S, Magli MC. Bone marrow-derived cells can
acquire cardiac stem cells properties in damaged heart. JCMM 2011 Jan; 15(1): 63-71. DOI:
10.1111/j.1582-4934.2009.00968.x

2. 13. Rocchetti M, Alemanni M, Mostacciuolo G, Barassi P, Altomare C, Chisci R, Micheletti R,
Ferrari P, Zaza A.(2008) Modulation of sarcoplasmic reticulum function by PST2744
[istaroxime; (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride)] in a
pressure-overload heart failure model. J Pharmacol Exp Ther. Sep;326(3):957-65.
14. Marcella Rocchetti, Vincenzo Freli, Valeria Perego, Claudia Altomare, Gaspare Mostacciuolo
and Antonio Zaza (2006). Rate-dependency of beta-adrenergic modulation of repolarizing
currents in the guinea-pig ventricle. J Physiol. 2006 Feb 16
15. Claudia Altomare, Jocelyn Bescond, Agnese tognati, Arnaldo Ferroni & Mirko Baruscotti
(2005). Direct inhibition of the pacemaker (If) current in rabbit sinoatrial node cells by genistein.
J. Br.Pharm. 147: 36–44
16. Claudia Altomare, Benedetta Terragni, Chiara Brioschi, Raffaella Milanesi, Cinzia Pagliuca,
Carlo Viscomi, Anna Moroni, Mirko Baruscotti and Dario DiFrancesco (2003). Heteromeric
HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial
node. J Physiol. 549:347-359
17. Jihong Qu, Claudia Altomare, Annalisa Bucchi, Dario DiFrancesco, and Richard Robinson.
(2002). Functional comparison of HCN isoforms expressed in ventricular and HEK cells.
Pflugers Arch 444(5):597-601
18. Gian Carlo Demontis, Anna Moroni, Biagio Gravante, Claudia Altomare, Biancamaria
Longoni, Luigi Cervetto and Dario DiFrancesco. (2002).Molecular and functional
characterization of native HCN1 channels in rabbit retinal rod photoreceptors. J Physiol. 2002 Jul
1;542(Pt1):89-97.
19. Carlo Viscomi, Claudia Altomare, Annalisa Bucchi, Eva Camatini, Mirko Baruscotti, Anna
Moroni, and Dario DiFrancesco. (2001). C terminus-mediated control of voltage and cAMP
gating of hyperpolarization-activated cyclic nucleotide-gated channels. The J.Biol.Chem. 276,
29930-29934.
20. Anna Moroni, Luisa Gorza, Monica Beltrame, Biagio gravante, Thomas Vaccari, Marco E.
Bianchi, Claudia Altomare, Renato Longhi, Catherine Heurteaux, Maurizio Vitadello, Antonio
Malgaroli and Dario DiFrancesco. (2001). Hyperpolarization-activated Cyclic Nucleotide-gated
Channel 1 Is a Molecular Determinant of the Cardiac Pacemaker Current If.. The J.Biol.Chem.
276, 29233-29241.
21. Claudia Altomare, Annalisa Bucchi, Eva Camatini, Mirko Baruscotti, Carlo Viscomi, Anna
Moroni, and Dario DiFrancesco D. (2001). Integrated allosteric model of voltage gating of HCN
channels. J. Gen. Physiol. 117, 519-532.
22. Moroni, Barbuti, A., Altomare, C., Viscomi, C., Morgan, J., Baruscotti, M. & DiFrancesco, D.
(2000) Kinetic and ionic properties of the human HCN2 pacemaker channel. Pflugers. 439, 618-
626
23. Altomare,C., Barbuti,A., Viscomi,C., Baruscotti, M. & DiFrancesco,D. (2000) Effects of SR
33589B on Acetylcholine activated current (IKACh) in single rabbit sinoatrial node cells. British J.
of Pharmacology. 130, 1315-1320.
24. Barbuti,A., Baruscotti,M., Altomare,C., Moroni,A. and DiFrancesco,D. (1999) Action of
internal pronase on the f-channel kinetics in the rabbit SA node. J.of Physiol.-520.3,737-744.
REVIEWS:

3. 1. Claudia Altomare & Matteo Mangoni (2005). Hyperpolarization-activated (f)-channels and the
HCN gene family: Structure and functional relevance of “pacemaker” channels in cardiac
automaticity. Recent Res. Devel. Physiol., ISBN: 81-308-0069-1
2. Lucio Barile, Claudia Altomare, Antonio Zaza (2011). Induced Pluripotent Stem Cells: progress
toward a biomedical application. Expert Rev Cardiovasc Ther. 2011 Oct;9(10):1265-9
CHAPTERS
1. Zaza A., Altomare C., Rocchetti M. (2006). Fisiologia normale e patologica dell'atrio. In:
Salerno-Uriarte J e DePonti R. Fibrillazione atriale dalla cellule alla clinica. (pp. 31-44). ROMA:
Società italiana di cardiologia (ITALY).
ABSTRACTS
1. Baruscotti,M., Altomare,C., DiFrancesco,D.& Robinson,R.B. (1998) Ionic basis for the effect of
TTX on spontaneus acitvity in neonatal rabbit sa node myocytes. Biophysical J.- 74.2 2-2 Abstr
295 A396
2. C. Altomare, Barbuti, A., Baruscotti, M., Moroni, A., Viscomi, C. & D. DiFrancesco (2000).
Effects of intracellular cleavage of rabbit SA node f-channel by aspecific protease. Pflugers
3. D. DiFrancesco, A. Moroni, M. Baruscotti, S. Priori, M.L. Oppizzi, C. Viscomi, C. Altomare &
A. Barbuti. (1999). The molecular characterization of the hyperpolarization-activated If/Ih
channel. Telethon Scientific Convention, Rimini, Nov. 14-16, Abstr. N. 72
4. D. DiFrancesco, A. Moroni, M. Baruscotti, C. Altomare & C. Viscomi.(2000). Molecular
characterization of HCN pacemaker channels. INFM Annual Meeting, Genova, 12-16 Giugno.
Abstr 3-134
5. C. Altomare, M. Baruscotti, A. Bucchi, E. Camatini, A. Moroni, C. Viscomi. & D. DiFrancesco
(2001). Allosteric voltage dependent gating of HCN channels. Bioph. J. 80: 2-2 Abstr 969 B178
6. C Altomare, L Barile, M Rocchetti, M Sampaolesi, A Giacomello and A Zaza. Caffeine-induced
Ca2+
signaling as an index of cardiac differentiation. (2007) Journal of Molecular and Cellular
Cardiology. Volume 42, Issue 6, Supplement 1 (Pages S89-S90)
7. Claudia Altomare, Lucio Barile, Stefano Marangoni, Marcella Rocchetti, Gaspare Mostacciuolo,
Alessandro Giacomello, Elisa Messina and Antonio Zaza (2008). Differentiation of cardiac-type
calcium release mechanism in cardiac precursor cells. European Heart Journal ( 2008 ) 29
( Abstract Supplement ), 527.
8. Claudia Altomare, Lucio Barile, Stefano Marangoni, Marcella Rocchetti, Gaspare Mostacciuolo,
Alessandro Giacomello, Elisa Messina and Antonio Zaza (2008). Cardiac-type Calcium Release
Mechanism in Cardiac Precursor Cells
Abstract 338: Circulation, Oct 2008; 118: S_287.
9. Stefania Crippa, Marco Cassano, Carlos Claver Clavel,Claudia Altomare, Daniela Galli, Laura
Perani, Graziella Messina, Antonio Zaza, Giulio Cossu and Maurilio Sampaolesi (2008). Cardiac
mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of both
adult normal and cardiomyopathic mouse ventricle. human Gene Therapy: vol 19 numb 10, 2008
pag1178

4. CONFERENCES
1998 European WorkGroup on Cardiac Cellular Electrophysiology – Milan (It)
Effect of SR 33589B on cardiac IKACh (Poster)
1999 European WorkGroup on Cardiac Cellular Electrophysiology – Oxford (UK)
C.Altomare, A.Barbuti, M.Baruscotti, A.Moroni, C.Viscomi, & D.DiFrancesco.
Pronase modifies gating and the response to cAMP of f-channels in the rabbit SAN (Poster)
1999 Società Italiana di Fisiologia-Roma-It
C.Altomare, A.Barbuti, M.Baruscotti, A.Moroni, C.Viscomi, & D.DiFrancesco.
Pronase modifies gating and the response to cAMP of f-channels in the rabbit SAN. (Oral Pres)
2000 European WorkGroup on Cardiac Cellular Electrophysiology – Bern (CH)
C.Altomare, M.Baruscotti, A. Bucchi, A.Moroni, C.Viscomi, & D.DiFrancesco.
Kinetic properties of HCN channels (Poster)
2001 European WorkGroup on Cardiac Cellular Electrophysiology – Dresden (D)
C.Altomare, A. Bucchi, C.Viscomi, A.Moroni, M.Baruscotti & D.DiFrancesco.
Kinetic properties of rHCN1 and rHCN4 coexpression (Poster)
2001 European WorkGroup on Cardiac Cellular Electrophysiology – Dresden (D)
M.Baruscotti, C.Altomare, A. Bucchi, A.Moroni, C.Viscomi & D.DiFrancesco.
Molecular cloning of the SAN Na channel (Poster)
2002 European WorkGroup on Cardiac Cellular Electrophysiology – Montpellier (F)
C.Altomare, B.Terragni , Milanesi R., C.Viscomi , A.Moroni, & D.DiFrancesco.
Properties of coexpressed HCN1/HCN4 channels as compared to native pacemaker channels.
(Poster)
2003 European WorkGroup on Cardiac Cellular Electrophysiology – Utrecht (NL)
C.Altomare, A. Barbuti, M. Riolfo, C. Brioschi, B. Terragni, A. Tognati
R. Milanesi, C.Viscomi, M . Baruscotti & D. DiFrancesco.
HCN1 and HCN4 contribution to the native pacemaker “funny” channel. (Poster)
2005 European WorkGroup on Cardiac Cellular Electrophysiology – Antwerp (B)
Tognati A., Brioschi C., Altomare C., Baruscotti M. & DiFrancesco D.
siRNA-mediated knockdown of the HCN4 gene in cultured neonatal SAN cells. (Poster)
European WorkGroup on Cardiac Cellular Electrophysiology– Antwerp (B)
V. Freli, M. Rocchetti, C. Altomare, G. Mostacciuolo, D. Avitabile, A. Zaza
Electrophysiological properties of human umbilical cord blood (UCB) stem cells cocultured onto
neonatal cardiac myocytes (Poster)
2006 European WorkGroup on Cardiac Cellular Electrophysiology– Florence (It)
C.Altomare, L.Barile, M.Rocchetti, E.Messina, A.Zaza.
Characterization of murine cardiac stem cells. (Oral Presentation)
2007 International Society for Heart Research-Bologna (I)
C. Altomare, L. Barile, S. Marangoni, M. Rocchetti, M. Sampaolesi, A. Giacomello and A.
Zaza. Caffeine-induced Ca2+
signaling as an index of cardiac differentiation. (Poster)
2007 European WorkGroup on Cardiac Cellular Electrophysiology– Manchester (UK)
C.Altomare, L.Barile, M.Rocchetti, E.Messina, A.Zaza.
Characterization of murine cardiac stem cells (CSCs). (Poster)
2008 European Society of Cardiology (ESC)-Munich (D)
C. Altomare, L. Barile, S. Marangoni, M. Rocchetti, M. Alemanni, G. Mostacciuolo, A.
Giacomello, E. Messina and A. Zaza. Differentiation of cardiac-type calcium release mechanism
in cardiac precursor cells. (Oral Presentation)
2008 American Heart (AHA)-New Orleans (USA)
C. Altomare, L. Barile, S. Marangoni, M. Rocchetti, M. Alemanni, G. Mostacciuolo, A.
Giacomello, E. Messina and A. Zaza. Differentiation of cardiac-type calcium release mechanism
in cardiac precursor cells. (Poster)
2009 International Symposium on “Cardiac Stem Cells differentiation and Biopsy-derived
CardiacRegenerative Cells: clinical implications of basic research” Organized by Gianluigi
Condorelli, Giacomo Frati, Alessandro-Roma (I)
Claudia Altomare & Antonio Zaza.

5. Functional evaluation of Cardiogenic differentiation in vitro. (Oral Presentation)
2011 European WorkGroup on Cardiac Cellular Electrophysiology– Oslo (N)
Claudia Altomare, Lucio Barile, Alice Villa, Luca Sala, Maurilio Sampaolesi, Marcella
Rocchetti, Antonio Zaza. β-sarcoglycan knock out switches differentiation of cardiac precursors
toward skeletal muscle (Poster Awards)
2012 Biophysical Society, 57th
meeting. San Diego (CA)
Claudia Altomare, Lucio Barile, Alice Villa, Luca Sala, Maurilio Sampaolesi, Marcella
Rocchetti, Antonio Zaza. β-sarcoglycan knock out switches differentiation of cardiac precursors
toward skeletal muscle
2013 Denis Escande Symposium - Amsterdam (NL)
Claudia Altomare, Luca Sala, Chiara Bartolucci, Gaspare Mostacciuolo, Stefano Severi and
Antonio Zaza. Ikr impact on repolarization and its variability assessed by Dynamic-Clamp (Poster
Awards)
Computing in Cardiology - Zaragoza (E)
Claudia Altomare, Luca Sala, Chiara Bartolucci, Gaspare Mostacciuolo, Stefano Severi and
Antonio Zaza. Ikr impact on repolarization and its variability assessed by Dynamic-Clamp (Oral
Presentation)
2014 Biophysical Society, 58th
meeting. San Francisco (CA)
Claudia Altomare, Luca Sala, Chiara Bartolucci, Gaspare Mostacciuolo, Stefano Severi and
Antonio Zaza. Ikr impact on repolarization and its variability assessed by Dynamic-Clamp
(Poster)
Rocchetti Marcella, Luca Sala, Carlotta Ronchi, Claudia Altomare, Manuela Mura, Francesca
Gullo, Alessandra Moretti, Massimilinao Gnecchi, Lia Crotti, Peter J. Schwartz, Antonio Zaza.
Genotype-Phenotype correlation in induced pluripotent stem cells (IPSc) -derived cardiomyocytes
carrying calmodulin mtations
2016 Biophysical Society, 60th
meeting. Los Angeles (CA)
Altomare C., Cervio E., Ciullo A., Milano G., Torre T., Demertzis S., Barile L. and Vassalli G.
Molecular Cardiology Laboratory, Fondazione Cardiocentro Ticino, Via Tesserete, 6900 Lugano,
Switzerland. Induced pluripotent stem (iPS) cells to assess the cardioprotective and
proangiogenic activities of exosomes secreted by human cardiac progenitor cells. (Poster)

6. Functional evaluation of Cardiogenic differentiation in vitro. (Oral Presentation)
2011 European WorkGroup on Cardiac Cellular Electrophysiology– Oslo (N)
Claudia Altomare, Lucio Barile, Alice Villa, Luca Sala, Maurilio Sampaolesi, Marcella
Rocchetti, Antonio Zaza. β-sarcoglycan knock out switches differentiation of cardiac precursors
toward skeletal muscle (Poster Awards)
2012 Biophysical Society, 57th
meeting. San Diego (CA)
Claudia Altomare, Lucio Barile, Alice Villa, Luca Sala, Maurilio Sampaolesi, Marcella
Rocchetti, Antonio Zaza. β-sarcoglycan knock out switches differentiation of cardiac precursors
toward skeletal muscle
2013 Denis Escande Symposium - Amsterdam (NL)
Claudia Altomare, Luca Sala, Chiara Bartolucci, Gaspare Mostacciuolo, Stefano Severi and
Antonio Zaza. Ikr impact on repolarization and its variability assessed by Dynamic-Clamp (Poster
Awards)
Computing in Cardiology - Zaragoza (E)
Claudia Altomare, Luca Sala, Chiara Bartolucci, Gaspare Mostacciuolo, Stefano Severi and
Antonio Zaza. Ikr impact on repolarization and its variability assessed by Dynamic-Clamp (Oral
Presentation)
2014 Biophysical Society, 58th
meeting. San Francisco (CA)
Claudia Altomare, Luca Sala, Chiara Bartolucci, Gaspare Mostacciuolo, Stefano Severi and
Antonio Zaza. Ikr impact on repolarization and its variability assessed by Dynamic-Clamp
(Poster)
Rocchetti Marcella, Luca Sala, Carlotta Ronchi, Claudia Altomare, Manuela Mura, Francesca
Gullo, Alessandra Moretti, Massimilinao Gnecchi, Lia Crotti, Peter J. Schwartz, Antonio Zaza.
Genotype-Phenotype correlation in induced pluripotent stem cells (IPSc) -derived cardiomyocytes
carrying calmodulin mtations
2016 Biophysical Society, 60th
meeting. Los Angeles (CA)
Altomare C., Cervio E., Ciullo A., Milano G., Torre T., Demertzis S., Barile L. and Vassalli G.
Molecular Cardiology Laboratory, Fondazione Cardiocentro Ticino, Via Tesserete, 6900 Lugano,
Switzerland. Induced pluripotent stem (iPS) cells to assess the cardioprotective and
proangiogenic activities of exosomes secreted by human cardiac progenitor cells. (Poster)