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Cannabis and Autism - Dr Christian Bogner, MD

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My presentation to the Aaps Meeting and Exposition in Denver, CO 10/16/16 about my findings on the primary cause of disordered endocannabinoid tone from neurotoxins such as glyphosate and how this plays with pathophysiology in autism spectrum disorders.

Published in: Health & Medicine
  • PLEASE make this into a video and post on a wider platform (like YouTube) - Bonus points if you can add narration. If you do please post a link here. This is awesome info and not just for autism.
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Cannabis and Autism - Dr Christian Bogner, MD

  1. 1. Autism & Cannabis Christian Bogner, MD Denver, Colorado 2016
  2. 2. DECLARATION • There is no conflict of interest in this lecture • I received no monetary benefit from this lecture • No implied sponsorship by any company to the speaker • No affiliation with the pharmaceutical or cannabis industry • All patients in this presentation had an informed consent for photography and publication
  3. 3. AUTISM TREATMENT WITH CANNABIS • I will not speak about • Dosage recommendations • Ratios • Strains
  4. 4. AUTISM TREATMENT WITH CANNABIS • I will speak about • Primary cause of disordered endocannabinoid tone: neurotoxins • Endocannabinoid pathophysiology in autism spectrum disorders
  5. 5. AUTISM FACTS -70% of the children with ASD have GI Issues compared to 42% of the children with developmental disorder other than ASD -Toxic overload (aluminum, mercury, copper) -Vitamin D deficiency -Systemic Inflammation
  6. 6. AUTISM Known facts -70% of the children with ASD have GI Issues compared to 42% of the children with developmental disorder other than ASD -Toxic overload (aluminum, mercury, copper) -Vitamin D deficiency -Systemic Inflammation WHAT CAUSES THIS ?
  7. 7. MONSANTO’S ROUNDUP
  8. 8. MONSANTO’S ROUNDUP Roundup=Glyphosate= N-(Phosphonomethyl)-glycine
  9. 9. GLYPHOSATE • Enzyme inhibitor • Antifungal agent • Herbicide • Uncoupling agent -National Center for Biotechnology Information
  10. 10. GLYPHOSATE -Glycine [a potent neurotransmitter / non-essential amino acid] -Formaldehyde [known neurotoxin affecting memory,learning,behavior] -Phosphorous Acid [white phosphorous used in chemical warfare] -Ullmann's Encyclopedia of Industrial Chemistry 7th ed
  11. 11. GLYPHOSATE pH (1% solution in water) 2.5. EPA: excretion of glyphosate is Feces (~70%) and Kidneys (~30%) -Ullmann's Encyclopedia of Industrial Chemistry 7th ed
  12. 12. GLYPHOSATE EVIDENCE OF DISEASE
  13. 13. GLYPHOSATE STUDIES • "Despite its relatively benign reputation, Roundup was among the most toxic herbicides and insecticides tested.” - University of Caen, Institute of Biology, Paris, France • "Case control studies in the USA, Canada and Sweden reported increased risk for NHL (Non-Hodgkin's lymphoma) associated with exposure to glyphosate. -International Agency for Research on Cancer, World Health Organization [WHO]
  14. 14. GLYPHOSATE GI TRACT • "Taken together, these data suggest that Roundup exposure may affect human reproduction and fetal development in case of contamination." -University of Caen, Institute of Biology, Paris, France • . Ingestion of >85 mL of the concentrated formulation is likely to cause significant toxicity in adults. Gastrointestinal corrosive effects. Renal and hepatic impairment are also frequent and usually reflect reduced organ perfusion. -Bradberry SM et al; Toxicol Rev 23 (3): 159-67 (2004)
  15. 15. GLYPHOSATE GI TRACT • Effects at 30,000 ppm included central lobular hepatocyte hypertrophy in males, central lobular hepatocyte necrosis in males, chronic interstitial nephritis in males, and proximal tubule epithelial basophilia and hypertrophy in females. -California Environmental Protection Agency/Department of Pesticide Regulation • The results/ suggest that acute toxicity at lethal doses may occur as a result of the uncoupling of oxidative phosphorylation. -WHO/International Programme on Chemical Safety; Environmental Health Criteria 159, Glyphosate, (1994).
  16. 16. GLYPHOSATE GI TRACT • "...in a long term combined study of toxicity and carcinogenicity in rats given glyphosate at normal doses, inflammation was observed in the stomach mucosa..." -International Agency for Research on Cancer, World Health Organization
  17. 17. GLYPHOSATE BRAIN • Taken together, these results demonstrated that Roundup might lead to excessive extracellular glutamate levels and consequently to glutamate excitotoxicity and oxidative stress in rat hippocampus. -Cattani D et al; Toxicology 320: 34-45 (2014)
  18. 18. GLYPHOSATE ENDOCRINE • The study tested the effects of glyphosate and Roundup at lower nontoxic concentrations on aromatase, the enzyme responsible for estrogen synthesis. The glyphosate-based herbicide disrupts aromatase activity and mRNA levels... -Richard S et al; Environ Health Perspect 113 (6): 716-20 (2005)]
  19. 19. GLYPHOSATE GENOTOXICITY • Glyphosate also caused DNA and chromosomal damage in human cells […] one study in community residents reported increases in blood markers of chromosomal damage (micronuclei) after glyphosate formulations were sprayed nearby. -WHO; IARC Monographs Volume 112: evaluation of five organophosphate insecticides and herbicides (March 20, 2015)
  20. 20. GLYPHOSATE MORE • Roundup exposure may affect human reproduction and fetal development in case of contamination [1] • Glyphosate is toxic to human placental JEG3 cells within 18 hr with concentrations lower than those found with agricultural use [2] • Maternal exposure to glyphosate disturbed the masculinization process in the offsping and promoted behavioral changes and histological and endocrine problems in reproductive parameters [3] • Roundup […] could contribute to Sertoli cell disruption in spermatogenesis that could have an impact on male fertility [4]
  21. 21. EPA STATEMENT • “Given increased public interest in glyphosate, EPA may recommend sampling for glyphosate in the future”. – Environmental Protection Agency, 2015
  22. 22. 5.2 PPM GLYPHOSATE
  23. 23. GLYPHOSATE EFFECTS • Oral glyphosate • Destruction of gastrointestinal bacteria via Shikimate pathway disruption • Malabsorption of tyrosine, tryptophan, phenylalanine • Gastrointestinal inflammation and leaky gut • Systemic absorption of protein • Systemic inflammation • Liver P450 enzyme destruction Stephanie Seneff, Senior Research Scientist,MIT
  24. 24. GLYPHOSATE SOURCES
  25. 25. 170 PPB GLYPHOSATE IN ENFAMIL PROSOBEE LIQUID CONCENTRATE SENEFF, SAMSEL, GLYPHOSATE, PATHWAYS TO MODERN DISEASES III: MANGANESE, NEUROLOGICAL DISEASES, AND ASSOCIATED PATHOLOGIES
  26. 26. 0.390 PPB GLYPHOSATE
  27. 27. VACCINES
  28. 28. VACCINES
  29. 29. MMR VACCINE
  30. 30. FROM GLYPHOSATE TO AUTISM
  31. 31. FOODBABE.COM
  32. 32. Picture by Dr. Hagmeyer
  33. 33. MOLECULAR EVIDENCE OF BRAIN INJURY
  34. 34. Glutamate Glycine
  35. 35. Glutamate
  36. 36. Glutamate Glycine
  37. 37. AUTISM BRAIN
  38. 38. MONSANTO’S ROUNDUP Roundup=Glyphosate= N-(Phosphonomethyl)-glycine
  39. 39. Glyphosate = Glycine
  40. 40. Glyphosate = GlycineGlutamate ?
  41. 41. Accelerated and abnormal brain growth in the Autistic MSG Used to Trigger Epileptic Seizures MSG Used to Trigger CNS and Brain Damage MSG Used to Damage Eye Cells in Vivo and in Vitro
  42. 42. Glyphosate = GlycineGlutamate ?
  43. 43. IN 1949 DR. MALHERBE TESTED A GROUP OF MENTALLY DISABLED CHILDREN TO SEE IF GLUTAMATE WOULD IMPROVE THEIR MENTAL CAPACITY. IT MADE THEM WORSE.
  44. 44. Glyphosate = GlycineGlutamate
  45. 45. Glyphosate = GlycineGlutamate
  46. 46. WHERE CAN WE FIND MASSIVE AMOUNT OF GLUTAMATE ?
  47. 47. MMR VACCINE 0.4mg monosodium-L-Glutamate
  48. 48. Glyphosate = GlycineGlutamate
  49. 49. WHY CBD IS NEEDED
  50. 50. US patent 6630507 US department of Health and Human Services ‘Cannabinoids as antioxidants and neuroprotectants’
  51. 51. ‘Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism’
  52. 52. "In the presence of glutamate alone, and in the presence of glutamate and cannabidiol (CBD) or THC, it was demonstrated that CBD and THC were similarly protective."
  53. 53. Glyphosate = GlycineGlutamate
  54. 54. Glyphosate = GlycineGlutamate
  55. 55. THE CASE FOR THC
  56. 56. • Endocannabinoid system • Memory consolidation • Memory Extinction
  57. 57. • Disrupt aspects of short- term (i.e. working) memory • Leave retrieval of well- learned information (i.e. long-term or reference memory) largely intact. CB1 AGONISTS -Cannabinoids as Therapeutics, Mechoulam ECS REFRESHER
  58. 58. • Disrupt aspects of short- term (i.e. working) memory • Leave retrieval of well- learned information (i.e. long-term or reference memory) largely intact. CB1 AGONISTS • Attentional mechanisms • Associational processes • Consolidation processes • Encoding processes • Retrieval processes
  59. 59. SKYWALKER Endocannabinoids, phytocannabinoids and synthetic cannabinoids effects on memory
  60. 60. CONDITIONAL DISCRIMINATION
  61. 61. CONDITIONAL DISCRIMINATION AUDITORY OR VISUAL STIMULUS (KNOWN) REFERENCE (LONG TERM) MEMORY
  62. 62. CONDITIONAL DISCRIMINATION AUDITORY OR VISUAL STIMULUS (UNKNOWN) WORKING (SHORT TERM) MEMORY
  63. 63. CONDITIONAL DISCRIMINATION WORKING (SHORT TERM) MEMORY
  64. 64. CONDITIONAL DISCRIMINATION WORKING (SHORT TERM) MEMORY SR-141716
  65. 65. CONDITIONAL DISCRIMINATION WORKING (SHORT TERM) MEMORY METHANANDAMIDE
  66. 66. CONDITIONAL DISCRIMINATION WORKING (SHORT TERM) MEMORY ESTROGEN
  67. 67. CONDITIONAL DISCRIMINATION WORKING (SHORT TERM) MEMORY ESTROGEN AUTISM BOYS 4.5 : 1 GIRLS
  68. 68. RELEVANCE • Without proper short term memory, long term memory formation is impaired • It would make sense that repetitive CB1 stimulation would cause the desired effect,e.g. with ABA therapy? Unfortunately, often limited to no effect in severe autism !
  69. 69. GLYPHOSATE VS BRAIN P450
  70. 70. BRAIN CYTOCHROME P450 D6 [CYP2D6] - Metabolizes many psychoactive compounds in the brain • implicated in neurodegeneration, psychosis, schizophrenia, and personality traits - involved in the oxidation of 20-30% of the most commonly prescribed drugs
  71. 71. BRAIN CYTOCHROME P450D6 • Endocannabinoid anandamide is metabolized by CYP2D6, resulting in the formation of multiple mono- and deoxygenated products • Oxidation of anandamide may result in the formation of novel signaling mediators
  72. 72. BRAIN • Increase in CYP2D6 in 13 different brain regions of alcoholics including the frontal cortex temporal cortex hippocampus substantia nigra all of which are areas of high CB1 expression and where anandamide is known to be produced.
  73. 73. P450D6 ANANDAMIDE 5,6EET-EAs CB1 CB2
  74. 74. P450D6 ANANDAMIDE 5,6EET-EAs CB1 CB2 During inflammation upregulated in 13 different brain regions (e.g.alcoholics)
  75. 75. P450D6 ANANDAMIDE 5,6EET-EAs CB1 CB2 300 fold selectivity 1000 fold affinity
  76. 76. CB2 receptors on Microglia [brain macrophages]
  77. 77. CYP2D6 ANANDAMIDE 5,6EET-EAs CB1 300 fold selectivity 1000 fold affinity
  78. 78. CYP2D6 ANANDAMIDE 5,6EET-EAs CB1 [AEA] 5,6EET-EAs
  79. 79. CYP2D6 ANANDAMIDE 5,6EET-EAs CB1 GLYPHOSATE
  80. 80. ‘Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism’
  81. 81. CB2 receptors on Microglia [brain macrophages] Also have TRVP receptors that CB2 activate
  82. 82. CYP2D6 ANANDAMIDE 5,6EET-EAs CB1 GLYPHOSATE CBD TRVP
  83. 83. CYP2D6 ANANDAMIDE 5,6EET-EAs CB1 GLYPHOSATE CBD TRVP delta9THC
  84. 84. THE BRADSTREET REVELATION
  85. 85. GCMAF – 85% IMPROVEMENT IN AUTISM
  86. 86. GCMAF – 85% IMPROVEMENT IN AUTISM
  87. 87. GCMAF P450 Activated vitamin D GCMAF Vitamin D3
  88. 88. GCMAF P450 Activated vitamin D GCMAF Vitamin D3 glyphosate
  89. 89. GCMAF P450 Activated vitamin D GCMAF Vitamin D3 glyphosate
  90. 90. BRADSTREET FAMILY REVELATION ‘85% IMPROVEMENT WITH CANNABIS ONLY’ IMPOSSIBLE TO PROFIT IN U.S. MARKET ?DATA OMITTED?
  91. 91. SUMMARY Protect brain from further toxic injury – THC/CBD OIL Restore the gastrointestinal system – PROBIOTICS Proper testing Proper education Proper diet (non-GMO, organic) Share information
  92. 92. THE FUTURE OF AUTISM
  93. 93. GCMAF P450 Activated vitamin D GCMAF Vitamin D3 glyphosate
  94. 94. GCMAF P450 Activated vitamin D GCMAF Vitamin D3
  95. 95. www.mammausa.org
  96. 96. http://uf4a.org/ The Unconventional Foundation for Autism
  97. 97. www.drbogner.com

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