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Endocannabinoid Signaling in Autism

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The endocannabinoid system plays a crucial part in the pathophysiology of autism. Major protective brain mechanisms are interrupted and neuroinflammation ensues. Organophosphates are potent inhibitors of crucial brain enzymes. The systemic consequences of defective microglial signaling, nagalase surges, and GcMAF metabolism are tightly interconnected into the basic idea that autism is an environmentally triggered neuroinflammatory condition.

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Endocannabinoid Signaling in Autism

  1. 1. DrBogner.com • Board Certified MD • OBGYN • Cornell Plant Based Nutrition • Researcher • Autism Father • Cannabis Advocate • Sign-up for Slides / Newsletter
  2. 2. Let’s Talk…
  3. 3. Autism & Cannabis Let’s Discuss…. • Evidence of brain inflammation (gliosis) • Primary cause of disordered endocannabinoid tone: neurotoxins • Endocannabinoid pathophysiology in autism spectrum disorders • Phytocannabinoid treatment
  4. 4. Autism + Cannabis + Warning •Limitations •Expectations •Laws / State •CPS
  5. 5. Autism Encephalitis is inflammation of the brain that occurs when a virus directly infects the brain or when a virus, vaccine, or something else triggers inflammation. “It’s Encephalitis” -Merck Manual 2017
  6. 6. What’s the evidence?
  7. 7. What could cause the inflammation?
  8. 8. Aluminum Adjuvants Glyphosate Nanoparticles Human retroviruses Soy (GMO) Yeast Polysorbate 80 Human DNA Bacterial / Viral antigens Glutamate
  9. 9. Aluminum Adjuvants Glyphosate Nanoparticles Human retroviruses Soy (GMO) Yeast Polysorbate 80 Human DNA Bacterial / Viral antigens Glutamate
  10. 10. WI-38 Rubella [RA-27] Measles Mumps Retrovirus Human DNA Human DNA MMR
  11. 11. 1983: 15 month of life. Autism rate 1:10,000 2016: 15 months of life. Autism rate 1:68
  12. 12. "Taken together, these data suggest that Roundup exposure may affect human reproduction and fetal development in case of contamination." -University of Caen, Institute of Biology, Paris, France
  13. 13. Ingestion of >85 mL of glyphosate is likely to cause significant toxicity in adults. Gastrointestinal corrosive effects, with mouth, throat and epigastric pain and dysphagia are common. Renal and hepatic impairment are also frequent and usually reflect reduced organ perfusion. -Bradberry 2004
  14. 14. Glyphosate
  15. 15. Polysorbate 80 Aluminum PANDAs Systemic Inflammation Prematurity Blood Brain Barrier Disruptors
  16. 16. Microglia Brain Central Intelligence
  17. 17. Aluminum Glyphosate Organophosphates ?Retrovirus Viral RNA Bacterial toxins
  18. 18. LPS (bacterial toxin) Aluminum Hemagluttinin (Measles) Double stranded RNA (Rotavirus)
  19. 19. Bacterial overgrowth Yeast Glyphosate Gluten Casein
  20. 20. Cannabis
  21. 21. Cannabis and AutismCannabis in the U.S.
  22. 22. 1850 – 1937 Prime medicine For 100 separate illnesses
  23. 23. Endocannabinoid Science
  24. 24. Cannabis Safety
  25. 25. Sumner H Burstein PhD University of Massachusetts Department of Biochemistry & Molecular Pharmacology Raphael Mechoulam, PhD Hebrew University of Jerusalem Isarel Academy of Sciences
  26. 26. Nora D. Volkow, MD Director NIDA 2003-current 2014 National Institute of Health
  27. 27. 2011 (source: NIDA) Israel Cannabis trials 110 USA Cannabis trials ~ 3 ‘A neglected pharmacological treasure trove’ -Raphael Mechoulam, PhD
  28. 28. Nausea & Vomiting Appetite Stimulation Multiple Sclerosis AIDS anorexia Seizures Pain Lennox Gestaut Syndrom Tuberous Sclerosis Infantile Spasms Plant CannabinoidsFDA approved synthetic Cannabinoids DEA: Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse.
  29. 29. www.phytecs.com
  30. 30. www.phytecs.com
  31. 31. Conclusion Testing Amino Acids (urine & plasma) Organic Acid Test (OAT) Stool parasites Comprehensive Urine Elements Heavy metals (urine & hair) IgG, IgA, IgM Candida Lyme 23andMe genetics Glyphosate Nagalase Hepatitis panel CIRS MRI brain EEG Treatments Based on testing results Organic diet Cannabis Supplements Chelators ABA OT Speech therapy Sun Exercise Patience
  32. 32. Microglial Signaling Honey CurcuminResveratrol Ginseng Apigenin Quercetin Luteolin Kaempferol
  33. 33. "If a law is unjust, a man is not only right to disobey it, he is obligated to do so.“ -Thomas Jefferson

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