2. Introduction:
⢠Introduction in 1960âs one of major inventions
in Neonatology.
⢠Along with Antenatal steroids and Surfactant
replacement ,ventilation played imp role in
increasing neonatal survival.
⢠Although life saving it may cause BPD.
3. Benefits of MV:
⢠Improve Gas exchange, by lung recruitment to
improve V/Q matching.
⢠Decrease WOB
⢠CO2 removal in babies with respiratory
depression and apnea.
4. Indications for Ventilation:
⢠Respiratory Acidosis,pH<7.2 and PaCO2> 60
mm Hg.
⢠Hypoxia PaO2<50 mmHg.
⢠Recurrent Apnea.
⢠Downes score> 7.
5. Common Conditions:
⢠RDS
⢠Apnea of Prematurity.
⢠Septicemia-Pneumonia
⢠Post operative recovery.
⢠PPHN
⢠MAS
⢠Congenital pulmonary or cardiac
anomalies(CDH).
6. Types of :
⢠CMV: Exchange of gas in bulk similar to tidal volume
Initiation of breath-Ventilator (CMV or IMV)
Patient
Tidal volume regulation- PC
VC
Breath is terminated- Volume
Time .
Flow regulated.
⢠HFV: small volume of gas at extremely rapid rate(300-
1500)
290 Modes on 33 Ventilators .
One ventilator- Care fusion Avea ,offers choice of 44 different modes
7. Initiation of Breath:
ďś Synchronised Ventilation:(Patient triggered)
-SIMV
-A/C Ventilation
-Pressure support ventilation(PSV)
-NAVA
ďś CMV or IMV.
Increase in death rate using SIMV(RR-1.19)
No difference in air leak,IVH,BPD,extubation failure
Shorter duration of Ventilation in SIMV(Mean difference -35 hrs)
13. NAVA
Observational studies have shown better synchrony, less PIP and
sedation with similar ABG
Further research needed to determine effects on outcome
16. Pressure Limited Ventilation:
⢠TCPL ventilators are MC used Neonatal
ventilators.
⢠Amount of pressure during inspiration is
set(PIP).
⢠TV delivered depends on PIP,Ti,Compliance
and synchrony.
18. Pressure Limited Ventilation(TCPL):
Advantages
⢠Relatively easy to use and less
costly.
⢠Continues flow of gas in circuit
allows for spontaneous
breathing.
⢠PIP and MAP can be adjusted
to optimize gas exchange and
minimize lung injury
Disadvantages
⢠Variation in TV from breath
to breath
⢠Increased WOB during
spontaneous breaths
⢠Poor synchrony decreased
O2,increase CO2,de TV,de
MV(overcome with
synchronization)
19. Volume Targeted Ventilation:
⢠Provides consistent TV resulting in less lung
injury.
⢠In 2011,volume targeted ventilation had
replaced pressure limited ventilation in 25 of
50 neonatal tertiary units.
⢠Volume control & Volume Guarantee
20. Volume Controlled Ventilation:
⢠Set TV (4-6ml/kg) is delivered by variation in
PIP.
⢠RR and max Ti are set.
⢠Measure TV delivered to circuit ,No
compensation for ET tube leaks
22. Volume guarntee(VG):
⢠Modified pressure targeted ventilation.
⢠Addition of microprocessor that adjusts the
pressure to ensure Targeted Tidal Volume(TTV).
⢠TV,Ti,Max PIP is set
⢠Flow sensor senses ex TV to adjust pressure for
next few breaths.
24. Controlling Volume ,a better mode?
⢠Costly and needs more expertise.
⢠Lower rate of death and BPD(RR-0.73).
⢠Reduced rate of Air leak(RR-0.46),days of
ventilation,Hypocarbia and neurologic
injury(RR-0.48)
25. Volume targeted ventilation with either SIMV
or A/C using modified TCPL ventilators with TTV
of 4-6ml/kg with permissive hypercarbia should
be initial mode of ventilation
27. Parameters in Conventional ventilation:
⢠Mode of ventilation
⢠PIP
⢠PEEP
⢠Flow
⢠Inspiratory time(Ti)
⢠Fio2
⢠Rate.
⢠Trigger
⢠Tidal Volume(TTV)
⢠I:E ratio
28. Setting PIP:
⢠PIP is the primary factor used to deliver tidal
volume
⢠PIP required mainly depends on the
compliance of lungs
⢠Useful clinical indicator of adequate PIP is
gentle chest rise with every vent breath.
⢠If compliance is normal, initiate with 12-14 If
abnormal, check chest rise on hand ventilation
30. Setting PEEP:
⢠Adequate PEEP improves FRC & V/Q mismatch
⢠PEEP levels between 3 â 6 improve
oxygenation & well tolerated
31. Setting PEEP:
⢠Choices are between 3 - 6
⢠If FRC is expected to be:
normal: 3
moderately reduced: 4
severly reduced: 5 â 6
⢠Low PEEP-Atelectotrauma
Co2 retention due to V/Q mismatch
⢠High PEEP-Decrease lung compliance
Impede venous return/ shock
Pulmonary air leaks
32. ⢠RR is one of the primary determinants of MV,
thus CO2 elimination
⢠No conclusive evidence for appropriate RR
⢠In SIMV mode ventilatory rate may not affect
ABG as much as anticipated
⢠Choices are between 20 to 60
⢠Considerations are:
- work of breathing
- Is there asynchrony: need for overdrive?
- pressure requirement ?
33. Setting FiO2:
⢠Choices are between 21-100%
⢠Target is Pa02 of 50-70 mm Hg with Spo2 of
88-95%.
⢠If lung compliance is good start with 21-25%
⢠Other lung conditions start with FiO2 50%
34. ⢠Very rapid rate may cause insufficient
inspiratory time and decreased tidal volume
⢠May lead to inadvertent PEEP and gas
trapping due to inadequate expiration
⢠CO2 retention, impaired cardiac output
High RR
⢠Low RR
35. Setting Ti:
⢠The respiratory system time constant
determines optimal Ti & Te
⢠Ideal Ti = 3 x time constant
⢠An Ti of 0.3 â 0.4 sec is commonly used
⢠In conditions like MAS â shorter Ti (0.25sec)
⢠In severe ARDS / Pulmonary hemorrhage
prolonged Ti (0.5 sec)
36. Setting Flow:
⢠Adequate flow rate is required for the
ventilator to deliver the desired PIP &
waveform
⢠Minimum flow rate of about 3 times the
infants MV
⢠Flows of 4 -10 L/min are sufficient for most
infants