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GKA deel 1 college 7

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Biology, Utrecht University
Biology, Utrecht University
Health & MedicineTechnology
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Overzicht deel tumoren ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Nature 442, 2006, 140
How cancer arises Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Progression to invasive tumor Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object]
Signal transduction: on and off Weinberg, Sci Am 275-3, 1996, 32-40 Avoid words such as ‘fires’
Some proto-oncogenes Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],======================================================
Some tumor suppressor genes Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Some tumor suppressor genes Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],DNA repair genen geen tumor suppressors noemen!
The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40
The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40
The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],Most cells are not cycling but in G 0 -stage
The pRb switch Weinberg, Sci Am 275-3, 1996, 32-40 E2F-member
The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40
The pRb switch Weinberg, Sci Am 275-3, 1996, 32-40 E2F-member
Progression to cell division Weinberg, Sci Am 275-3, 1996, 32-40 mdm2 p21 p21 waf : see Vogelstein Proteins involved in DNA synthesis Liberated Transcription factors Active pRb protein complexed with inactive transcription factors (master brake) Transforming growth factor ß (an inhibitor) Cell division DNA synthesis Growth promoting signals issued vy neighboring cells
Progression to cell division Weinberg, Sci Am 275-3, 1996, 32-40 mdm2 p21 p21 waf : see Vogelstein Proteins involved in DNA synthesis Liberated Transcription factors Active pRb protein complexed with inactive transcription factors (master brake) Transforming growth factor ß (an inhibitor) Cell division DNA synthesis Growth promoting signals issued vy neighboring cells
The Ink4 locus Kim & Sharpless, 2006, Cell 127, 265-275 ,[object Object],[object Object],[object Object],[object Object],[object Object],Inserted 4-12-07 http://www.mtmlabs.com/cda/science_technology/ p16supink4a/sup/content-121885.html
Effect of activating c-myc (from Alberts et al. 2002)
Effect of activating c-myc (from Alberts et al. 2002)
Aberrant chromosomes: aneuploidy Weinberg, Sci Am 275-3, 1996, 32-40 ,[object Object],[object Object],[object Object],[object Object],[object Object],Karyotype ============

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GKA deel 1 college 7

  • 1.  
  • 2.
  • 3.
  • 4.
  • 5. Signal transduction: on and off Weinberg, Sci Am 275-3, 1996, 32-40 Avoid words such as ‘fires’
  • 6.
  • 7.
  • 8.
  • 9. The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40
  • 10. The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40
  • 11.
  • 12. The pRb switch Weinberg, Sci Am 275-3, 1996, 32-40 E2F-member
  • 13. The cell cycle Weinberg, Sci Am 275-3, 1996, 32-40
  • 14. The pRb switch Weinberg, Sci Am 275-3, 1996, 32-40 E2F-member
  • 15. Progression to cell division Weinberg, Sci Am 275-3, 1996, 32-40 mdm2 p21 p21 waf : see Vogelstein Proteins involved in DNA synthesis Liberated Transcription factors Active pRb protein complexed with inactive transcription factors (master brake) Transforming growth factor ß (an inhibitor) Cell division DNA synthesis Growth promoting signals issued vy neighboring cells
  • 16. Progression to cell division Weinberg, Sci Am 275-3, 1996, 32-40 mdm2 p21 p21 waf : see Vogelstein Proteins involved in DNA synthesis Liberated Transcription factors Active pRb protein complexed with inactive transcription factors (master brake) Transforming growth factor ß (an inhibitor) Cell division DNA synthesis Growth promoting signals issued vy neighboring cells
  • 17.
  • 18. Effect of activating c-myc (from Alberts et al. 2002)
  • 19. Effect of activating c-myc (from Alberts et al. 2002)
  • 20.