Tumor suppressor gene


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Riyadh college for dentistry and pharmacy

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Tumor suppressor gene

  1. 1. By: PH. Amani Al-Ismail PH. Marwa Chalati Tumor suppressor Gene
  2. 2. OUTLINE <ul><li>Cell cycle </li></ul>Introduction Definition Regulation of cell cycle Tumor suppressor genes: Overview Function Types Examples
  3. 3. introduction <ul><li>Cell cycle </li></ul>
  4. 5. Regulation of cell cycle
  5. 10. <ul><li>Tumor Suppressor Genes </li></ul>
  6. 11. What different mechanisms they do?
  7. 12. Rb Gene
  8. 13. P53 Gene
  9. 14. Overview Of Tumor Suppressor Genes <ul><li>Harris, 1969 </li></ul><ul><li>Harris, 1971 </li></ul>
  10. 15. What are Tumor suppressor genes ?
  11. 16. <ul><li>Genes are Responsible for the inhibitory control </li></ul><ul><li>of cellular replication. </li></ul>
  12. 17. Biological Function Of Tumor Suppressor Genes
  13. 18. Types of Tumor Suppressor Genes
  14. 19. Some examples of Tumor suppressor Genes Fore of these genes have mainly study and absence of their product lead to development various of malignant tumor ISOLATE CROMOSOM CANCER GENE 1986 Crom.13q Retinoblastoma RB 1990 Crom.17p Osteosaracoma P53 1991 Crom.5q Colon APC 1993 Crom.3p Renal carcinoma VHL 1994 Crom.9p Melanoma P16 1994 Crom.17q Brest censer BRCA1 1995 Crom.13q Brest censer BRCA2
  15. 20. Retinoblastoma(R b ) gene
  16. 21. Retinoblastoma <ul><li>Retinoblastoma: A malignant tumor of retina in infants. </li></ul><ul><li>Two mutations are required in Rb gene to develop retinoblastoma </li></ul>
  17. 24. p53 A key tumor suppressor The guardian of the genome
  18. 25. Li-Fraumeni syndrome (LFS) <ul><li>People with LFS have a higher risk for developing a number of cancers, including soft-tissue and bone sarcoma, brain tumors, breast cancer, adrenal gland cancer, and leukemia. </li></ul><ul><li>Also susceptible to many sporadic cancers such as lung cancers, colon cancers and breast cancers. </li></ul>
  19. 26. BRCA1 and BRCA2 genes <ul><li>Brest(BR) cancer(CA) susceptibility genes, also incriminated in some ovarian cancers </li></ul>
  20. 27. Stimuli that affect Tumor Suppressor Genes Levels <ul><li>Ionizing radiation </li></ul><ul><li>UV radiation </li></ul><ul><li>Hypoxia </li></ul><ul><li>Heat shock </li></ul><ul><li>Growth factor withdrawal </li></ul><ul><li>Oncogenic activation: Ras, Myc </li></ul><ul><li>Cytotoxic drugs </li></ul><ul><li>Cigarettes </li></ul>
  21. 29. Future Directions <ul><li>Many researchers are very optimistic about the future of cancer therapies using tumor suppressor genes. There are many clinical trials underway at the present time that could lead to better treatments for many types of cancer. </li></ul>
  22. 32. References <ul><li>http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CellCycle.html </li></ul><ul><li>http://www.biology.arizona.edu/Cell_bio/tutorials/cell_cycle/cells3.html </li></ul><ul><li>http://homepage.mac.com/enognog/checkpoint.htm </li></ul><ul><li>http://www.cellsalive.com/cell_cycle.htm </li></ul><ul><li>HENKY HAEEIS, The role of differentiation in the suppression of malignancy, </li></ul><ul><li>Hiroyuki Niida; Makoto Nakanishi, DNA damage checkpoints in mammals, Mutagenesis vol. 21 no. 1 pp. 3–9, 2006 doi:10.1093/mutage/gei063 Advance Access Publication 28 November 2005 </li></ul><ul><li>Stephen J. Elledge, Cell Cycle Checkpoints: Preventing an Identity Crisis, Science 6 December 1996: Vol. 274. no. 5293, pp. 1664 – 1672 DOI: 10.1126/science.274.5293.1664 </li></ul>