Aplastic anemia In children

1. Aplastic Anemia
Name-Sharma Anuj
Group-55

2. General information of disease
Aplastic anemia is a serious condition in which the bone marrow
does not produce enough new blood cells .
It may be passed down from the parents or develop sometime
during childhood .
Some symptoms include tiredness,paleness,frequent
infections,and easy bruising and bleeding !.

3. Name- Priya
Age-4 years old
A mother came with 4 years old female child with symptoms of fever
from past 2 weeks,has become more and more pale and
weak,complained of pain in the abdomen .measles at 2 years of
age ,no complications.
Child has no history of tuberculosis or syphilis ,no members of the
family have had any disease of the blood ! or the blood forming
organs .

4. Objective examination
Fever " more than 38.9* c
Skin pigmentation
Short stature
Microcephaly
Hypogonadism
Mental retardation
Skeletal anomalies

5. Primary diagnosis
Aplastic anemia
No lymphadenopathy
No murmur
No marked enlargement
Lungs # -Negative
Liver and spleen - normal

6. Laboratory $ diagnosis
Panytopenia
Bone marrow histology and cytology
-decreased marrow cellularity(<25%)
-increased fat cells component
No extensive fibrosis
-no malignancy or storage disease
-Dry T
ap(little materials)

7. Differential Diagnosis
Fanconi Anemia
Dyskeratosis Congenita
Acute Myelogenous leukemia
Anemia
Hairy cell leukemia
Paroxysmal nocturnal hemoglobinuria

8. T
reatment
Supportive care
Severe anemia-Packed Red cells
Severe thrombocytopenia-Platelet T
ransfusion
Infection-Antibiotics
Definitive therapy-Hematopoietic stem cell T
ransplant(HRCT)

9. THANKYOU %