This research project developed a methodology for optimally sizing solar photovoltaic systems connected to the grid and isolated systems in tropical regions of America. The methodology determines the optimal panel angle, panel type and technology, feasibility of solar trackers, and importance of meteorological data to optimize system autonomy and battery requirements. A comparative analysis was performed using PVSYST and HOMER Pro simulations to validate sizing and optimization. An economic analysis of microgrids was also conducted. The methodology was applied to size isolated and grid-connected systems for cases in Bucaramanga, optimizing autonomy for an isolated home system and replacing consumed energy for a commercial user. Results showed a 17% reduction in initial costs for conventionally sized isolated