An exhaustive and insightful summary of Parkinson's disease including pathophysiology, epidemiology and several other ologies.

1. Parkinson’s Disease
Steven J. Zuckerman, M.D.
Diagnosis and Treatment

2. James Parkinson

3. The Shaking Palsy

4. Anatomy

5. Basal Ganglia
• Direct and Indirect Pathways

6. Basal Ganglia
• Direct Pathway

7. Basal Ganglia
• Indirect Pathway

8. Epidemiology

9. Epidemiology

10. Pathogenesis

11. Braak Hypothesis

12. Clinical Features
Both Motor and
Non-Motor

13. Four Cardinal Motor Features:

14. 1. Tremor

15. Cogwheeling Rigidity

16. Bradykinesia

17. Abnormal Gait

18. Postural Instability

19. Glabellar Reflex

20. DAT Scan

21. Non-Motor Symptoms

22. All that shakes is not PD
PD vs Essential Tremor

23. All that shakes is not PD
Parkinson Plus Syndromes

24. Treatment

25. Carbidopa/Levodopa
•Sinemet
•Sinemet CR
•Apokyn
•Parcopa
•Rytary
•Stalevo

26. Dopamine Agonists
• Mirapex (Pramipexole)
• Mirapex ER
• Requip (Ropinirole)
• Requip XL
• Neupro (Rotigatine)

27. MAO-B & COMT Inhibitors
• Azilect (Rasagiline)
• Zelapar (Selegeline)
• Comtan (Entacapone)

28. Others
• Anti-Cholinergic
• Artane (Trihexyphenidyl)
• Cogentin (Benztropine)
• Amantadine

29. Motor Complications

30. Algorithm

31. Surgical Intervention

32. Intestinal Infusion

33. Treatment of Non-Motor Symptoms