3. Factors Influencing Choice
Features of illness, e.g.
agitation, hypersomia
Suicide risk
Other therapy
Other illness.
Side effects
Cost
Special problems e.g.
Age, driving,
pregnancy
5. Tricyclics
Amitryptyline
Potent sedative
Weight gain ++
Anticholinergic ++
Most researched
150mg / day
(Therapeutic in 95%
of adults)
Clomipramine
Similar side effects
to amitryptyline.
Said to be best for
obsessional
symptoms.
150mg / day
6. Tricyclics
Dothiepin
Sedative
Same side effects
as amitryptyline.
By far and away
the most toxic
antidepressant.
150 mg / day
Imipramine
Stimulant
Anticholinergic ++
150 mg/ day
7. Tricyclics
Lofepramine
Least toxic TCA.
Minimal sedative
side effects.
Anticholinergic +
Doubts about
efficacy.
210 mg / day
Protriptyline
Stimulant.
Anticholinergic +
40mg / day
8. Tetracyclics
Maprotiline
Similar side effect
profile to
amitryptyline.
Seizures severe in
overdose.
150 mg /day
Mianserin
Good safety in
overdose.
Few sedative or
anticholinergic
properties.
? Agranulocytosis
risk
90 mg / day
9. SSRI
First choice in
elderly.
First choice if
heart disease.
First choice if
suicide risk.
More expensive.
Side effects
Like TCA reduce
with time.
Gut problems
predominate.
Flat dose response
curve – so no need
to titrate dose
upwards.
?
11. SSNRI
Venlafaxine
Selective Serotonin and noradrenaline
reuptake inhibitor – like amitryptyline.
Few other effects – unlike amitryptyline.
75-150mg / day minimum
Dry mouth, somnolence, high BP, nausea,
headache and dizziness.
12. MAOI
The old ones block peripheral
MAOI ( B ) and central MAOI (A)
so a low tyramine diet is needed. ?
Obsolete.
Moclobemide.
Only MAOI-A.
? Role.
? Special place in anxiety disorder.
300-600mg / day.
14. Oddities
Tryptophan
Natural amino acid - Serotonin
precursor.
Eosinophilia-myalgia syndrome,
Hospital initiation only.
Adjuvant to others ?
Flupenthixol
Some doubts as to efficacy.
Fast action
1 mg / day
15. Adjuvants and Combinations
Realm of
specialists
Lithium,
carbamazepine
Mixtures i.e. SSRI
and TCA
Dangerous – need
expert supervision
16. Anxiety
Usually worth trying a
antidepressant.
May be useful to avoid
the stimulant ones !
May need higher doses.
Initiation may lead to
paradoxical increase in
symptoms. ? Cover with
short course of anxiolytic.
17. Anxiety
? Role of
benzodiazepines.
? Beta-blockers.
Buspirone.
Some efficacy, but
small.
Slow onset, 2-4
weeks.
18. DSM - IV
Duration > 2 weeks
Depressed mood or Marked loss of interest
or pleasure in normal activities
Plus 4 of:
i. Significant change in weight
ii. Significant change in sleep pattern
iii. Agitation or retardation
iv. Fatigue or loss of energy
v. Guilt / worthlessness
vi. Can’t concentrate or make decisions
vii.Thoughts of death or suicide
19. Incidence Of Depression:
2000 Patients
100 - major
100 - minor
200 -
subclinical
Depression. In 50% of patients it
may not be acknowledged.
20. ICD - 10
Patient has low mood:
1) How bad is it and how long has it
been going on?
2) Have you lost interest in things?
3) Are you more tired than usual?
21. ICD - 10
Mild
Two criteria from 1-3 and 2 others.
Moderate
Two criteria from 1-3 and 3-4 others or a
yes to question 5.
Severe
Most of the criteria in severe form
especially questions 5 & 9.
22. BUT BUT BUT
But there is a lot
more than the
drugs.
The use of other
therapies is
equally important.
The doctor may be
the best drug.
Availability is
often the limit to
other treatment
methods.
23. Based On
BNF June 2000.
Depression in General Practice.
Tylee, Priest & Roberts. Pub. Martin
Dunitz. 1996.
GP Psychotropic Handbook. S
Bazire. Quay Books. 1995.
Basic Notes in Psychiatry. Michael
Levi. Kluwer Books. 1997.