Life cycle of plasmodium

34,303 views

Published on

FOR MORE MEDICAL PRESENTATIONS AND MEDICAL VIDEOS JOIN
http://medicalpresentation.blogspot.in/

Published in: Health & Medicine
3 Comments
37 Likes
Statistics
Notes
  • tq for the slide. it really help me.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • save
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • I am searching for Plasmodium falciparum vaccines for my PG scholar, before that i looked for the life cycle first
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
No Downloads
Views
Total views
34,303
On SlideShare
0
From Embeds
0
Number of Embeds
199
Actions
Shares
0
Downloads
1,070
Comments
3
Likes
37
Embeds 0
No embeds

No notes for slide

Life cycle of plasmodium

  1. 1. MalariaIntroduction & Lifecycle of Plasmodium
  2. 2. INTRODUCTION• Malaria is a mosquito-borne infectious disease caused by intracellular protozoan parasite Plasmodium.• Characterized by cycles of shaking, chills, fever, sweating and anaemia.• Affects 500 million and kills more than 1 million people each year.• Endemic in tropical and subtropical regions – Sub-Saharan Africa, Asia and Latin America.• In India, about 1.5 – 2 million cases and 1000 malarial deaths are reported annually (mostly from tribal, hilly and inaccessible areas).
  3. 3. Causative AgentsPlasmodium species Human infectionPlasmodium vivax Benign tertian malariaPlasmodium falciparum Malignant tertian / Pernicious malaria (most common and fatal) (complications – Cerebral malaria and Black water fever)Plasmodium malariae Quartan malariaPlasmodium ovale Ovale tertian malaria
  4. 4. Contd..• All forms are transmitted by the infective bite of female Anopheles mosquitoes.• Transmission through blood transfusion can also occur.• Man develops disease after 10 to 14 days of being bitten by an infective mosquito.
  5. 5. Ring-forms and gametocytes of Plasmodium falciparum in human blood.
  6. 6. Lifecycle of Plasmodium• 2 stages 1) Sexual phase in the mosquito 2) Asexual phase in humans a) Exoerthrocytic (Pre-erythrocytic) shizogony b) Erythrocytic shizogony• The infectious stage of malaria - Sporozoite (found in the salivary glands of female mosquitoes).
  7. 7. Life cycle in humans• Mosquito takes a blood meal → Sporozoites released into human’s blood → infect liver cells• EXO-ERYTHROCYTIC STAGE :- Parasites inside heparocyte → Shizont (containing thousands of merozoites) → infected hepatocytes release about 30,000 Merozoites (asexual, haploid forms) → quickly infect red cells. * [P. vivax and P. ovale form latent Hypnozoites in hepatocytes, which cause relapses of malaria long after initial infection]
  8. 8. ERYTHROCYTIC STAGE :-• Within the red cells the parasites grow in a membrane-bound digestive vacuole, hydrolyzing haemoglobin through secreted enzymes.• A) Continuation of asexual reproduction - Most of the parasites develop into Trophozoites → Schizont → multiple chromatin in schizonts develop into Merozoites → Red cell lysis & merozoites infect other red cells. B) Production of gametocytes - Some parasites develop into sexual forms called Gametocytes → infect the mosquito.
  9. 9. Thank you

×