1. Translating discovery science into improved
health through technological innovation

2. An Integrated Life Sciences Campus

3. UHB QE Hospital
Future location Children’s Hospital
NIHR-WT CRF
Advanced Therapy Facility
Royal Centre Defence Medicine
Trauma Research Centre
Institute of Biomedical Research
Centre for Translational
Inflammation Research
Institute Translational Medicine
Medical School
CRUK Cancer Centre
Public Health Research
Primary Care
University of Birmingham

4. IBR
WM AHSN
PATIENT &
Adoption
POPULATION
Education
HEALTH
Clinical Trials
Digital Technology
Wealth Creation
Integrated Care
CLAHRC
DISCOVERY SCIENCE
EFFECTIVENESS
HEALTH ECONOMICS
BHP
IMPLEMENTATION
CLINICAL
TRIALS
CLINICAL
OBSERVATIONS
EXPERIMENTAL
MEDICINE
CRC TU
BCTU
PCTU
NIHR
WT CRF

5. Focussed Research Strategy with
World Leading Outputs
CLINICAL ACADEMIC GROUPS
STRATIFIED MEDICINE
SCIENTIFIC
DISCOVERY
CLINICAL TRIALS
SURGERY, DEVICES, DIAGNOSTICS
ENABLING TECHNOLOGIES
COMMERCIALISATION
EDUCATION
PATIENT & PUBLIC INVOLVEMENT
CHRONIC
INFLAMMATORY
DISEASE
CANCER
ENDOCRINOLOGY
& METABOLISM
PATIENT
BENEFIT
REGIONAL
DEVELOPMENT
GLOBAL
IMPACT

6. Translational Research Underpinned by
Nationally Funded Centres
Chronic Inflammation
MRC CENTRE
IMMUNE
REGULATION
MRC-ARUK
CENTRE M-S
AGEING
ARUK RA
CENTRE of
EXCELLENCE
NIHR BRU
LIVER
DISEASE
NIHR TRP
Joint and
Inflammatory
Disease
NIHR Wellcome
Trust CRF
ARUK
BEAT RA
NIHR
CLAHRC WM
Endocrine & Metabolism
Cancer
CRUK
CANCER
CENTRE
CRUK TRIALS
UNIT
ECMC
LLR CENTRE
EXPERIMENTAL
CANCER
CENTRE
CLINICAL
HEMATOLOGY
TAP
NIHR
TRAUMA
HTC
NIHR TRC
ENDOCRINE
NEOPLASIA
NIHR
TRAUMA
CENTRE
HEALING
FOUNDATION
CENTRE FOR
BURNS
NIHR TRC
RARE
DISEASES
CRUK
Technology
Hub
ERDF
Biomedical
Innovation Hub
NICE External
Assessment
Centre
EPSRC Multidisciplinary
Assessment of
Technology Centre for
Healthcare (MATCH)

7. Digital Technology Supports Excellence in Care
EDUCATION
SERVICE IMPROVEMENT
CLINICAL AUDIT
RESEARCH

8. Research Advances Embedded in Education
and Training to all Health Workers
• Clinical academic training
– Inspire student programme
– Royal College of Surgeons trainee programme
– Clinical fellows embedded in NIHRWT CRF
• New models
– Empowering NHS Consultants to deliver research
• Multidisciplinary – Allied Health Professionals
– Common CPD, CME, e-learning platforms across BHP
– Centre for Research in Medical & Dental Education

9. The Institute of Translational Medicine (ITM)
- co-locating all components of an effective
translational infrastructure
• UK Government £12m
• BHP £12m
• To open June 2015
A UNIQUE TRANSLATIONAL FACILITY WITH
STRATIFIED MEDICINE AT ITS CORE

10. Inflammation research in Birmingham
EATC
BEAT-RA
TRP’s
MRC Centre
Theme 3
Inflammation
Biology
MRC-ABPI
SSfH
CRF
IRF
ARUK-MRC
Ageing
Centre for Translational Inflammation Research
MRC Centre for Immune
Regulation

11. The Birmingham Inflammation Group
CVS
Brain
e.g. MS
Teeth
Liver
Liver
Process
Driven
Pathology
Eye
Lung
Lung
Skin
Joint
Joint Kidney
Current Situation
In Chronic Inflammation
•Fragmentation
•Duplication
•Disease specific funding
•Short term
•Diagnosis to pathology
Birmingham Inflammation Group
•Integration
•Multidisciplinary
•Process specific funding
•Durability
•Pathology to Diagnosis

12. Inflammation Research Facility
CVS
Brain
e.g. MS
Teeth
Liver
Liver
Eye
Lung
Shared
Cohorts
And IT
(co-morbidity)
Lung
Skin
Joint
Joint Kidney
Current Situation
In Chronic Inflammation
•Primary-secondary care split
•No core data set
•No information on co-morbidity
•Lack of real world data
IRF
(supported by WT CRF)
•Integration across 1ry and 2ry
•Core data set
•Respiratory, CVS, metabolic, periodontal
•Within NHS Research Clinics

13. Experimental Arthritis in Birmingham
• Unique stromal expertise
• Highly focused basic science and expanding early arthritis
cohorts
• Direct access to patient tissue samples
• Discrete stromal target discovery programmes
• Multiple pre-clinical animal models
• Internal and Industry therapeutic candidates
Markers
Epigenetics
SSFH
Protein
expression
In vitro
function
Periodontal
cohort
samples
target
discovery
validation
pre-clinical
studies
cohort:
therapy

14. Operational Partnership
UHBFT Queen Elizabeth Hospital
Centre for Translational
Inflammation
Integrated clinical and laboratory space
WTCRF satellite (IRF)
NIHR Trauma Centre
ARUK/MRC CoE in MSK ageing research
ARUK EATC (BEAT-RA)
Translational Research Partnership
ARUK CoE in Pathogenesis of RA

15. Strategy for UK Life Sciences
UK wide strategy
• Reduce bureaucracy
• £310m for stratified medicine
and commercial research
• Opt out for research data
• Encourage industry
engagement
• Stimulate economic growth