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OPTIMIZATION TECHNIQUES
Suraj C.
AACP
2
PPT. Package
Concept Of Optimization
Optimization Parameters
Classical Optimization
Statistical Design
Simulation & Search
3
INTRODUCTION
4
INTRODUCTION
5
• In development projects , one generally
experiments by :
 a series of logical steps,
 carefully controlling the variables &
 changing one at a time, until a satisfactory
system is obtained
• It is not a screening technique.
IDEA !
6
OPTIMIZATION TECHNIQUES
Parametric
Non-
Parametric
Factorial
Central
Composite
Mixture
Lagrangian
Multiple
Regression
Fractional
Factorial
Plackett-
Burman
Evolutionary
methods
EVOP REVOP
CLASSICAL OPTIMIZATION
7
• Involves application of calculus to basic
problem for maximum/minimum function.
• One factor at a time (OFAT).
• Restrict attention to one factor at a time.
• Not more than 2 variables.
CLASSICAL OPTIMIZATION
8
• Using calculus the graph obtained can be solved.
Y = f (x)
• When the relation for the response y is given as the
function of two independent variables,X1 & X2
Y = f(X1 , X2)
• The above function is represented by contour plots on
which the axes represents the independent variables X1&
X2
Contd…..
CLASSICAL OPTIMIZATION
9
Response
Variable
Independent
Variable
Contd…..
CLASSICAL OPTIMIZATION
10
Independent
Variable - X2
Independent
Variable - X1
Contd…..
OFAT vs DOE
11
Properties OFAT DOE
Type Classical- Sequenctial one
one factor method
Scientific – simultaneous
with multiple factor
method
No. of experiments High – Decided by
experimenter
Limited – Selected by
design
Conclusion Inconclusive – Interaction
Interaction unknown
Comprehensive –
Interactions studied too.
Precision & Efficiency Poor – sometimes
misleading result with
errors (4 exp.)
High – Errors are shared
evenly (2 exp.)
Consequences One exp. Wrong… all goes
goes wrong -Inconclusive
Orthogoanl design –
Predictable & conclusive
Information gained Less per experiment High per experiment
STATISTICAL DESIGN
12
• Techniques used divided in to two types:
1. Experimentation continues as optimization
proceeds
2. Experimentation is completed before
optimization takes place.
STATISTICAL DESIGN
13
• Experimentation is completed before
optimization takes place.
 Theoretical approach
 Empirical or experimental approach
Contd…..
STATISTICAL TERMS
14
• Relationship with single independent variable -
Simple regression analysis or Least squares method.
• Relationship with more than one important variable -
Statistical design of experiment & Multi linear
regression analysis.
• Most widely used experimental plan is Factorial
design.
STATISTICAL DESIGN
15
• Optimization: helpful in shortening the experimenting
time.
• DOE: is a structured , organized method used to
determine the relationship between –
 the factors affecting a process &
 the output of that process.
• Statistical DOE: planning process + appropriate data
collected + analysed statistically.
Contd…..
MATHEMATICAL MODELS
16
• Permits the interpretation of RESPONSES more
economically & becomes less ambiguous.
1. First Order: 2 Levels of the factor – Linear
 LCL (Lower control limit) - {-ve or -1}
 UCL (Upper control limit) - {+ve or +1}
2. Second Order: 3 Levels (Mid-level) – coded as “0” –
Curvature effect
FIRST ORDER
17
X1
Response
LOW HIGH
Predictable Response at X1
SECOND ORDER
18
X1
Response
LOW HIGH
True Response
SIMULATION & SEARCH
METHODS
19
• Search method does not requires CONTINUITY or
DIFFERENTIALITY function.
• Search methods also known as - “Sequential
optimization”.
NOTE: Simulation involves the computability of a
response.
SIMULATION & SEARCH
METHODS
20
• A simple inspection of experimental results is
sufficient to choose the desired product.
• If the independent variable is Qualitative – Visual
observation is enough.
• Computer aid not required, but if it there then added
advantage.
• Even 5 variables can be handled at once.
Contd…..
SIMULATION & SEARCH
(types)
21
 Steepest Ascent Method
 Response Surface Methodology (RSM)
 Contour Plots
Steepest Ascent Method
22
• Procedure for moving sequentially along the path
(or direction) in order to obtain max. ↑ in response.
• Applied to analyze the responses obtained from:
1. Factorial Designs
2. Fractional Factorial Designs
NOTE: Initial estimates of DOE are far from actual, so
method chosen for optimum value.
Response Surface Methodology (RSM)
23
• A 3-D geometric representation that establishes an
empirical relationship between responses &
independent variables.
• For:
 Determining changes in response surface
 Determining optimal set of experimental
conditions
NOTE: Overlap of plots for complete info is possible.
Contour Plots
24
• Are 2-D (X1 & X2) graphs in which some variables are
held at one desired level & specific response noted.
• Both axes are in experimental units.
• Sometimes both the contour & RSM plots are drawn
together for better optimum values.
Contour Plots
25
RSM & Contour
Combined
26

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Optimization in QBD

  • 2. 2 PPT. Package Concept Of Optimization Optimization Parameters Classical Optimization Statistical Design Simulation & Search
  • 5. 5 • In development projects , one generally experiments by :  a series of logical steps,  carefully controlling the variables &  changing one at a time, until a satisfactory system is obtained • It is not a screening technique. IDEA !
  • 7. CLASSICAL OPTIMIZATION 7 • Involves application of calculus to basic problem for maximum/minimum function. • One factor at a time (OFAT). • Restrict attention to one factor at a time. • Not more than 2 variables.
  • 8. CLASSICAL OPTIMIZATION 8 • Using calculus the graph obtained can be solved. Y = f (x) • When the relation for the response y is given as the function of two independent variables,X1 & X2 Y = f(X1 , X2) • The above function is represented by contour plots on which the axes represents the independent variables X1& X2 Contd…..
  • 10. CLASSICAL OPTIMIZATION 10 Independent Variable - X2 Independent Variable - X1 Contd…..
  • 11. OFAT vs DOE 11 Properties OFAT DOE Type Classical- Sequenctial one one factor method Scientific – simultaneous with multiple factor method No. of experiments High – Decided by experimenter Limited – Selected by design Conclusion Inconclusive – Interaction Interaction unknown Comprehensive – Interactions studied too. Precision & Efficiency Poor – sometimes misleading result with errors (4 exp.) High – Errors are shared evenly (2 exp.) Consequences One exp. Wrong… all goes goes wrong -Inconclusive Orthogoanl design – Predictable & conclusive Information gained Less per experiment High per experiment
  • 12. STATISTICAL DESIGN 12 • Techniques used divided in to two types: 1. Experimentation continues as optimization proceeds 2. Experimentation is completed before optimization takes place.
  • 13. STATISTICAL DESIGN 13 • Experimentation is completed before optimization takes place.  Theoretical approach  Empirical or experimental approach Contd…..
  • 14. STATISTICAL TERMS 14 • Relationship with single independent variable - Simple regression analysis or Least squares method. • Relationship with more than one important variable - Statistical design of experiment & Multi linear regression analysis. • Most widely used experimental plan is Factorial design.
  • 15. STATISTICAL DESIGN 15 • Optimization: helpful in shortening the experimenting time. • DOE: is a structured , organized method used to determine the relationship between –  the factors affecting a process &  the output of that process. • Statistical DOE: planning process + appropriate data collected + analysed statistically. Contd…..
  • 16. MATHEMATICAL MODELS 16 • Permits the interpretation of RESPONSES more economically & becomes less ambiguous. 1. First Order: 2 Levels of the factor – Linear  LCL (Lower control limit) - {-ve or -1}  UCL (Upper control limit) - {+ve or +1} 2. Second Order: 3 Levels (Mid-level) – coded as “0” – Curvature effect
  • 19. SIMULATION & SEARCH METHODS 19 • Search method does not requires CONTINUITY or DIFFERENTIALITY function. • Search methods also known as - “Sequential optimization”. NOTE: Simulation involves the computability of a response.
  • 20. SIMULATION & SEARCH METHODS 20 • A simple inspection of experimental results is sufficient to choose the desired product. • If the independent variable is Qualitative – Visual observation is enough. • Computer aid not required, but if it there then added advantage. • Even 5 variables can be handled at once. Contd…..
  • 21. SIMULATION & SEARCH (types) 21  Steepest Ascent Method  Response Surface Methodology (RSM)  Contour Plots
  • 22. Steepest Ascent Method 22 • Procedure for moving sequentially along the path (or direction) in order to obtain max. ↑ in response. • Applied to analyze the responses obtained from: 1. Factorial Designs 2. Fractional Factorial Designs NOTE: Initial estimates of DOE are far from actual, so method chosen for optimum value.
  • 23. Response Surface Methodology (RSM) 23 • A 3-D geometric representation that establishes an empirical relationship between responses & independent variables. • For:  Determining changes in response surface  Determining optimal set of experimental conditions NOTE: Overlap of plots for complete info is possible.
  • 24. Contour Plots 24 • Are 2-D (X1 & X2) graphs in which some variables are held at one desired level & specific response noted. • Both axes are in experimental units. • Sometimes both the contour & RSM plots are drawn together for better optimum values.
  • 25. Contour Plots 25 RSM & Contour Combined
  • 26. 26

Editor's Notes

  1. TERM = to make perfect used in pharmacy relative to formulation and processing. process of finding the best way of using the existing resources while taking in to the account of all the factors that influences decisions in any experiment
  2. TERM = to make perfect used in pharmacy relative to formulation and processing. process of finding the best way of using the existing resources while taking in to the account of all the factors that influences decisions in any experiment
  3. represented by evolutionary operations(EVOP), simplex methods. represented by classic mathematical & search methods
  4. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  5. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  6. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  7. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  8. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  9. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  10. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  11. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  12. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.
  13. If theoretical equation is known , no experimentation is necessary With single independent variable formulator experiments at several levels.