Veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT) conditioning or high-dose non-transplant chemotherapy. VOD/SOS with multi-organ dysfunction (MOD) is associated with a mortality rate of > 80% (Richardson, Aggarwal et al). The VOD Health Economics and Outcomes Research (HEOR) team at NOVEL Health Strategies recently conducted an exploratory analysis of all-payer national database to develop hypothesis on burden of VOD in Medicaid patients

1. Burden of Veno-Occlusive Disease in US Medicaid Patients
Pilot RWE Analysis by NOVEL Health Strategies
February 2022
NOVEL Leads
Saurabh (Rob) Aggarwal, PhD
Ozlem Topaloglu, MPH, PhD
NOVEL Health Strategies
sa@novelhealthstrategies.com
www.NOVELHealthStrategies.com
NOVEL Health Strategies, Washington DC, +1-646-717-4789, www.NOVELHealthStrategies.com

2. Mean LOS for Medicaid VOD patients is 53.5 days (more than
double of Medicare patients)

3. Mean Hospital charges for Medicaid VOD patients are $1.5 Millon

4. Mortality in Medicaid VOD patients is ~16% (for Medicare it was 33%)

5. Medicaid VOD patients have significantly higher co-morbidities

6. While 33% of Medicare patients came to hospital via ED, most
Medicaid patients were directly admitted to the hospital

7. Co-diagnosis trend shows 100% of Medicaid patients had liver disease