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Remote sensing liquid-liquid interface for drug delivery
- 1. Remote sensing the liquid-liquid interface: detecting micro-transport across cell membrane for better drug delivery 1Tapas Goswami, 2Debabrata Goswami 1School of Technology, The Glocal University, Saharanpur 2Department of Chemistry, Indian Institute of Technology Kanpur 1
- 2. Objective Affected cell Neat water Interface bulk Cell membrane mimic Dye solution in DCM solvent Blood Drug delivery Quantronix coherent Ultrafast Laser 2
- 3. Molecules of Choice IR125 dye is used in medical diagnosis Has potential application in photodynamic therapy S1 T indocyanine green dye (IR-125) triplet-state S0 triplet-state molecules could convert groundstate triplet-oxygen to excited singlet-state oxygen with high cell killing potential indole maroon dye (IR-144) (Tricarbocyanine dye) Journal of Photochemistry and Photobiology A: Chemistry 128 (1999) 101–109 3
- 4. Interface Setup Quantronix coherent Ultrafast Laser T. Goswami S.K.K. Kumar, A. Dutta, D. Goswami, J. Phys. Chem. B 113 (2009) 16332-39 4
- 6. Excited state life time of the dye @ Different Positions with respect to the Interface 1.2 raw data Z= -3mm raw data Z= -700 m raw data Z= -500 m raw data Z= -300 m raw data Z= -100 m Normalized Probe Transmittance 1.0 fitted data Z= -3mm fitted data Z= -700 m fitted data Z= -500 m fitted data Z= -300 m fitted data Z= -100 m Bulk Interface 0.8 interface 0.6 S1 T 0.4 0.2 S0 0.0 Bulk 0 2000 4000 6000 8000 10000 Probe Delay (fs) T. Goswami S.K.K. Kumar, A. Dutta, D. Goswami, J. Phys. Chem. B 113 (2009) 16332-39 6
- 7. Excited State Lifetime for IR125 in DCM interfaced with water at different Z-Positions excited state life life fs) Excited statetime ( time (fs) 3500 3000 2500 2000 1500 1000 500 0 -3000 Bulk -2500 -2000 -1500 Z ( m) -1000 -500 0 Interface 7
- 8. Proposed Mechanism Water layer Water layer Interface Bulk DCM layer (a) DCM layer (b) T. Goswami S.K.K. Kumar, A. Dutta, D. Goswami, J. Phys. Chem. B 113 (2009) 16332-39 8
- 9. Conclusion 1. Excited state relaxation rate is observed to be significantly slower in case of interfacially perturbed dye molecules near the DCM-water interface compared to that in the bulk solution. 2. Near the interface the excited state life time of the dye molecule is more. 3. Interfacially perturbed molecule has more triplet state lifetime, so more effective for photodynamic therapy. 9
- 10. THANKS 10
Editor's Notes
- Good afternoon everybody...title of my talk is remote sensing the liquid-liquid interface: detecting micro-transport across cell membrane for better drug delivery.
- So the objective of my research...When you take a medicine or drug, it is first dissolved in blood, then the drug is transported from blood to the infected cell through the cell membrane. I wanted to investigate this transport of drug across the cell membrane, also the effectiveness of the drug molecule at different positions with respect to the cell membrane.In laboratory it is very difficult and impossible to set up this experiment. So in laboratory we mimic the cell membrane with an immiscible liquid-liquid interface. The dye which is also used as a drug is dissolved in an organic solvent and it is interfaced with neat water. Then a sophisticated laser is used to detect the microtransport of the drug molecule.