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SEGURIDAD CLINICA Y PRACTICA
     CLINICA REFLEXIVA
                            Francesc Borrell i Carrió.
Profesor Titular de MFC, Facultad Medicina, Universidad Barcelona, Departament de
                        Ciències Clíniques. EAP Gavarra. ICS
                          Email.- 12902fbc@comb.cat
CONTENIDOS
Introducción.-
    Modelo centrado en el paciente. Self awareness.
El acto clínico.-
    Lo que sabemos
          -Estudios epidemiológicos.
          -Estudios de performance, (Pacientes Incógnito).

Estrategias de mejora.
   El profesional
   El sistema.

        -Prefaseg.
VALORES CLAVE DEL MODELO
• AFLORAR: necesidades, perspectiva y valores
  del paciente.

• COMPARTIR: decisiones, comprensión.

• CONSTRUIR: una relación empática y
  sensible (responsiveness).
MODELO CENTRADO EN EL PACIENTE
      TAREAS EN LA ENTREVISTA.
• FASE EXPLORATORIA:
  – El paciente puede hablar. Ocupación verbal.
  – Más allá del síntoma aparece la persona:
     • Creencias, ilusiones, expectativas, miedos…
• FASE RESOLUTIVA:
  – El paciente puede participar:
     • En la definición de su problema.
     • En el plan de actuación.
PRACTICA CLINICA REFLEXIVA.
• ME OBSERVO:
  – En el “ahora”, sin idealizarme, escuchando mis
    emociones que me advierten de peligros.
• REFLEXION EN LA ACCION:
  – Escuchamos y exploramos para crearnos una imagen
    del paciente. Independencia de criterio.
  – Integro los datos en la persona:
     • Terreno biológico, contexto psicosocial.
• REFLEXION FUERA DE LA CONSULTA:
  – Gestión poblacional. Prevención.
  – Gestión individual:
     • Pongo al paciente en mi agenda.
     • Comparto con el equipo.
¿Aporta algo que no nos aporte
    el enfoque sistémico?

  Acciones claras y muchas veces simples.
              Accountability.
        Políticas organizacionales.
ESTUDIOS INTERNACIONALES
•   Leape L, Brennan TA, Laird N, et al. The nature of adverse events in hospitalized
    patients: results of the Harvard Medical Practice Study II. N Engl J Med. 1991;324:377–
    384.
•   Wilson RM, Harrison BT, Gibberd RW, Hamilton JD. An analysis of the causes of adverse
    events from the Quality in Australian Health Care Study. Med J Aust. 1999;170:411–
    415.
•   Bhasale A, Miller G, Reid S, Britt HC. Analyzing potential harm in Australian general
    practice: an incident-monitoring study. Med J Aust. 1998;169:73–76.

•   Thomas EJ, Studdert DM, Burstin HR, et al. Incidence and types of adverse events and
    negligent care in Utah and Colorado. Med Care. 2000;38:261–271.

•   Baker GR, Norton PG, Flintoft V, et al. The Canadian Adverse Events Study: the
    incidence of adverse events among hospital patients in Canada. CMAJ. 2004;170:1678
    –1686.
•   Davis P, Lay-Yee R, Briant R, Ali W, Scott A, Schug S. Adverse events in New Zealand
    public hospitals II: preventability and clinical context. N Z Med J. 2003;116:U624.
ERROR MEDICO
                     ENEAS         9,3% (525/5.624); IC95%: 8,6% - 10,1%
                     INGRESOS
•   Toma de datos.   •               Medicación:                37,4%
                     •               Infecciones nosocomiales   25,3%
•   Diagnósticos.    •
                     •
                                     Problemas técnicos
                                     Diagnóstico
                                                                25,0%
                                                                2,75%

•   Tratamiento.     APEAS
                     CONSULTAS
                                   11,18‰ (IC95%: 10,52 - 11,85).

                     •                Medicación:                48,2%
•   Seguimiento.     •                Cuidados                  25,7%
                     •                Comunicación              24,6%
                     •                Diagnóstico               13,1%
                     •                Gestión                     8,9%
                     •                Otros                      14,4%

                     IBEAS, (10,5% EA) OTROS.-


                                                                    Jesús María Aranaz
                                                                    Andrés
TOTAL   Moderados-
                       graves
Eventos        47,7%   30,0%-5,7%
adversos
relacionados
conla
medicación
RAM            59,1%   66,1%
evitables
LO QUE NO PUEDE VER EL APEAS
• Errores en la comunicación y relación
  asistencial.

• Desacierto diagnóstico o falta de
  diagnóstico sin consecuencias inmediatas y
  no percibido por informante.

• Omisión de maniobras diagnósticas,
  terapéuticas o preventivas.

• Falta de seguimiento.
INCLUSO CUANDO TENEMOS SISTEMA
 DE NOTIFICACION CONFIDENCIAL….
Muchos errores diagnósticos no se detectan como
  EA:
• “La mayor parte de errores diagnosticos
  prevenibles no se informan a través de los
  medios de notificación voluntario”. Fischer G, Fetters
    MD, Munro AP, Goldman EB. Adverse events in primary care identified from a
    risk-management database. J Fam Pract. 1997;45:40–46
• Ninguno de los errores de diagnóstico que revelaron los
  residentes había sido informado a las base de datos.
•   Weingart S, Ship A, Aronson M. Confidential clinical-reported surveillance of
    adverse events among medical inpatients. J Gen Intern Med. 2000;15:470–477.
“NEGACIONISMO”
•   El 28% eran “negadores”(I.C95%: 22.34-34.26),
•   67 % “perceptivos” (I.C95%: 60.79-73.23),
•   7.4% “hiperperceptivos” (I.C95%: 4.41-11.44),
•   6% “locus interno”(I.C95%: 3.34-9.91),
•   23.4 % hiperseguros(I.C95%: 18.14-29.22).

•   Se informó sobre 10.6 acontecimientos adversos/año/profesional,
    sobretodo eventos adversos de fármacos (37%)(I.C95%: 35.36-39.15) , y
    retraso diagnóstico en patología neoplásica (33%) (I.C95%: 31.16-34.85).
                    Borrell F, Paez C, Suñol R, Orrego C, Gil N, Marti M Errores clínicos y eventos
                    adversos: p
                    ercepción de los médicos de atención primaria. Aten Primaria 2006; 38(1):25-32



Solo 1% admite públicamente haberse equivocado en el último año.


     Berner ES, Graber ML Overconfidence as a Cause of Diagnostic Error in Medicine
     The American Journal of Medicine (2008) Vol 121 (5A), S2–S23
Graber ML. 5 años, 3 centros, 100 casos
        de error diagnóstico.
 • *Sistémicos: fallos tecnológicos, mala organización. 65%
 • *No error: falta colaboración paciente, presentación atípica 44%
 • *Cognitivos: falta de conocimiento, toma de datos, sintesis de datos.
   74%

 •   Dentro de los cognitivos:
 •   Falta de conocimientos 11 ocasiones
 •   Falta de datos tomados del paciente: 45
 •   Falta de procesamiento adecuado de la información 159
 •   Falta de verificación 106
 •                   CAUSA PROFUNDA: CIERRE PRECIPITADO
          Graber ML, Franklin N, Gordon RR. Diagnostic error in internal
          medicine. Arch Intern Med. 2005;165:1493–1499.
“Error diagnóstico”

• “Diagnostic error”: retraso no intencionado
  (existía suficiente información previa),
  equivocado(otro diagnóstico se realizó antes
  del correcto), o no presente (no se realizó
  diagnóstico), desde la perspectiva de una
  información final mas definitiva.


           Graber ML, Franklin N, Gordon RR. Diagnostic error in internal
           medicine. Arch Intern Med. 2005;165:1493–1499.
Errores por especialidades
• -Especialidades perceptivas: radiologia 5%, A
  Patologica <5%, Dermatologia 11%.
• -Especialidades médicas 10-15%.
• -Superior en urgencias y entornos de alta
  densidad de decisiones.



 Berner ES, Graber ML Overconfidence as a Cause of Diagnostic Error in Medicine
 The American Journal of Medicine (2008) Vol 121 (5A), S2–S23
Errores por patologias
Entidad                  %     Cometarios

Aneurisma Aorta          35%   Precordialgias, 1era evaluacion sin diag.

Hemorragia subaracn      30%   1era. evaluacion sin diagnóstico

Mamografia Ca mama       21%   1era. lectura con error

T. Bipolar               69%   Diagnóstico inicial incorrecto

Artr. Psoriásica         39%   1era vista reumatólogo no diagn.

Diabetes Mellitus        18%   No consta diagnóstico en HC

Lectura Radiografias     30%   Errores cuando leídas en consulta (no
                               radiólogo).
EL ENFOQUE SISTEMICO DEBE
  AFRONTAR UNA REALIDAD
        INCOMODA



LA PERSONA ES PARTE DEL SISTEMA
EL MEDICO COMO CAJA NEGRA


datos                   Decisiones
                        Actos
EL MEDICO COMO CAJA NEGRA
                     • FALIBILIDAD.
                     • MEJOR EFICIENCIA.
                         – Curva de rendimiento.
                     • MANTENIMIENTO
                     • “OXIDACION”



¡SI AL MENOS SE NOS CONSIDERARA COMO UNA MÁQUINA!
¿COMO APROXIMARNOS A ESTA
   INCOMODA REALIDAD?


     ESTUDIOS DE LABORATORIO
   ESTUDIOS EN LAS CONDICIONES
    NATURALES DEL PROFESIONAL
ESTUDIOS NIVEL 4

       PIRAMIDE DE MILLER
PACIENTE ESTANDARIZADO Y
               ENMASCARADO



PREPARACION                    VISITA CON
                               AUDIOGRABACION



   ENMASCARAMIENTO




                                RECUPERACION
              SALA ESPERA       DE DATOS –
                                ENCUESTA
ESTUDIOS ESPAÑOLES
• Suñol R: Correlación entre los procesos y los
  resultados de la Entrevista Clínica: su aplicación a
  los programas de calidad en Atención Primaria. Tesis
  Doctoral, Universidad Autónoma de Barcelona.
  Barcelona, 1992
• Prados Castillejo, JA. Distorsión en las Técnicas
  Comunicacionales (Entrevista Clínica) en las
  consultas de Demanda de Atención Primaria. Tesis
  Doctoral. Universidad de Córdoba. Facultad de
  Medicina. Departamento de Medicina. Córdoba
  1996 .
• Barragán N, Violan C, Martín Cantera C, Ferrer-Vidal
  D, González-Algas J. Diseño de un método para la
  evaluación de la competencia clínica en atención
  primaria Aten Primaria. 2000 Nov 30;26(9):590-4.
ESTUDIOS ESPAÑOLES
• Borrell F.,Fontova B, Muñoz E, Prados JA,
  Pedregal M, Peguero E. Physician s ability
  to find a physical sign (hepatomegaly).
  European Journal Gen Pract 2011.
• Llor C, Cots JM. The sale of antibiotics
  without prescription in pharmacies in
  Catalonia, Spain.Clin Infect Dis. 2009 May
  15;48(10):1345-9.
ESTUDIOS INTERNACIONALES
• 46 TRABAJOS, 24 EN LOS ÚLTIMOS 5 AÑOS.
1.-McLeod PJ, et al. Use of standardized patients to assess between-physician variations in resource utilization JAMA. 1997 Oct 8;278(14):1164-8
2.-Dresselhaus TR, et al The ethical problem of false positives: a prospective evaluation of physician reporting in the medical record J Med Ethics. 2002 Oct;28(5):291-4
3.- Rethans jj, Sturmans F, Drop R, Van der Vleuten c, Hobus P. Does competence of general practitioners predict their performance? Comparison between examination setting and actual practices BMJ 1991 Nov 30;303(6814):1377
4.-.- Suñol R: Correlación entre los procesos y los resultados de la Entrevista Clínica: su aplicación a los programas de calidad en Atención Primaria. Tesis Doctoral, Universidad Autónoma de Barcelona. Barcelona, 1992
5.- Borrell F.,Fontova B, Muñoz E, Prados JA, Pedregal M, Peguero E. Physician s ability to find a physical sign (hepatomegaly). European J Gen Pract 2011.
6.-Franz CE, Epstein R, Miller KN, Brown A, Song J, Feldman M, Franks P, Kelly-Reif S, Kravitz RL. Caught in the act? Prevalence, predictors, and consequences of physician detection of unannounced standardized patients. Health Serv R
7.-Gallagher TH, Lo B, Chesney M, Christensen K. How do physicians respond to patient's requests for costly, unindicated services?
J Gen Intern Med. 1997 Nov;12(11):663-8.
8.-Kravitz RL, Epstein RM, Feldman MD, Franz CE, Azari R, Wilkes MS, Hinton L, Franks P. Influence of patients' requests for direct-to-consumer advertised antidepressants: a randomized controlled trial.
JAMA. 2005 Apr 27;293(16):1995-2002.
9.-Brown JA, Abelson J, Woodward CA, Hutchison B, Norman G. Fielding standardized patients in primary care settings: lessons from a study using unannounced standardized patients to assess preventive care practices. Int J Qual Hea
10.-Zabar S, Ark T, Gillespie C, Hsieh A, Kalet A, Kachur E, Manko J, Regan L. Can unannounced standardized patients assess professionalism and communication skills in the emergency department? Acad Emerg Med. 2009 Sep;16(9):9
11.-Epstein RM, Levenkron JC, Frarey L, Thompson J, Anderson K, Franks P. Improving physicians' HIV risk-assessment skills using announced and unannounced standardized patients. J Gen Intern Med. 2001 Mar;16(3):176
12.-Srinivasan M, Franks P, Meredith LS, Fiscella K, Epstein RM, Kravitz RL. Connoisseurs of care? Unannounced standardized patients' ratings of physicians. Med Care. 2006 Dec;44(12):1092-8.
13.- Fiscella K, Franks P, Srinivasan M, Kravitz RL, Epstein R. Ratings of physician communication by real and standardized patients. Ann Fam Med. 2007 Mar-Apr;5(2):151-8.
14.- Ozuah PO, Reznik M. Residents' asthma communication skills in announced versus unannounced standardized patient exercises.
Ambul Pediatr. 2007 Nov-Dec;7(6):445-8.
15.- Barragán N, Violan C, Martín Cantera C, Ferrer-Vidal D, González-Algas J. Diseño de un método para la evaluación de la competencia clínica en atención primaria Aten Primaria. 2000 Nov 30;26(9):590-4.
16.- Prados Castillejo, JA. Distorsión en las Técnicas Comunicacionales (Entrevista Clínica) en las consultas de Demanda de Atención Primaria. Tesis Doctoral. Universidad de Córdoba. Facultad de Medicina. Departamento de Medicina.
17.-Krane NK, Anderson D, Lazarus CJ, Termini M, Bowdish B, Chauvin S, Fonseca V. Physician practice behavior and practice guidelines: using unannounced standardized patients to gather data.
J Gen Intern Med. 2009 Jan;24(1):53-6. Epub 2008 Oct 31.
18.- Feldman MD, Franks P, Duberstein PR, Vannoy S, Epstein R, Kravitz RL. Let's not talk about it: suicide inquiry in primary care.
Ann Fam Med. 2007 Sep-Oct;5(5):412-8.
19. Epstein RM, Shields CG, Meldrum SC, Fiscella K, Carroll J, Carney PA, Duberstein PR. Physicians' responses to patients' medically unexplained symptoms. Psychosom Med. 2006 Mar-Apr;68(2):269-76.
20. Seaburn DB, Morse D, McDaniel SH, Beckman H, Silberman J, Epstein R. Physician responses to ambiguous patient symptoms.
 J Gen Intern Med. 2005 Jun;20(6):525-30.
21.- Peabody JW, Luck J, Jain S, Bertenthal D, Glassman P. Assessing the accuracy of administrative data in health information systems.
 Med Care. 2004 Nov;42(11):1066-72.
22. Carney PA, Dietrich AJ, Eliassen MS, Owen M, Badger LW. Recognizing and managing depression in primary care: a standardized patient study. J Fam Pract. 1999 Dec;48(12):965-72.
23.-Kravitz RL, Franks P, Feldman M, Meredith LS, Hinton L, Franz C, Duberstein P, Epstein RM. What drives referral from primary care physicians to mental health specialists? A randomized trial using actors portraying depressive sym
24.- Woodward CA, Hutchison B, Norman GR, Brown JA, Abelson J.
What factors influence primary care physicians' charges for their services? An exploratory study using standardized patients. CMAJ. 1998 Jan 27;158(2):197-202.
25.- Rethans JJ, Saebu L. Do general practitioners act consistently in real practice when they meet the same patient twice? Examination of intradoctor variation using standardised (simulated) patients. BMJ. 1997 Apr 19;314(7088):1
RESUMEN DE ESTOS TRABAJOS


     Fiabilidad, validez, detección o
  sospecha del paciente, factibilidad y
       satisfacción del profesional.
ASPECTOS GENERALES
• PSI mejor método para analizar acto asistencial.
• Competencia y Performance son diferentes.
• Historia Clínica (notas clínicas) poco fiables para
  juzgar calidad.
• El Paciente Problema inhibe habilidades de
  anamnesis.
• Gran esfuerzo para gestionar el tiempo.
• Las expectativas del paciente marcan diferentes
  “finales”.
SITUEMOS ESTOS HALLAZGOS EN
             UN MODELO



Borrell-Carrió F. Epstein R
Preventing errors in clinical practice: a call for self-
awareness
Ann Fam Med 2004;2(4):310-316.
¿COMO LLEGAMOS A UN
           DIAGNÓSTICO?
SITUACIÓN-            PRIMERAS
ESTÍMULAR:            HIPÒTESIS
INTENCIONALIDAD
                                                  REENCUADRE
                     CONDUCTAS
                     VERIFICACIÓN
                                                COLAPSO
                                                COGNITIVO
                    CONDICIONES DE
                    SUFICIENCIA


             “OFERTA” QUE HAREMOS AL PACIENTE
CAPACIDAD VERSUS DISPOSICION.
• CAPACIDAD: COMPETENCIA, NIVEL 3.
  “GENOTIPO”.

• DISPOSICIÓN: PERFORMANCE, NIVEL 4.
  “FENOTIPO”.    FACTORES RESTRICTIVOS


• CAPACIDAD :
                             LO QUE SOY CAPAZ DE HACER
•    PERCEPTIVA,             AHORA Y AQUÍ
•    COGNITIVA,
•    CONDUCTUAL.
DISPOSICIONES AFECTIVAS, ACTITUDINALES/
         CARACTERIALES Y COGNITIVAS.
• AFECTIVAS:
•      ESTADOS TRANSITORIOS: cansancio, ruido, calor o frío,
  hiperestimulación sensorial, deprivación sueño, etc.

•         SITUACION CLINICA: agresividad, contra- transferencia,
    atribuciones…

•         SITUACION AFECTIVA ENDOGENA: trastorno del humor, de ansiedad,
    trastornos ciclotímicos, circadianos, etc.


Pat Croskerry, Allan A Abbass, Albert W Wu How doctors feel: aff ective issues in
patients’ safety
The Lancet Vol 372 October 4, 2008 1205-6
DISPOSICIONES AFECTIVAS, ACTITUDINALES/
       CARACTERIALES Y COGNITIVAS.
• ACTITUDINALES / CARACTERIALES:
• Rasgos polares que limitan o sesgan la percepción y o el razonamiento.-
•       -Profesional frío, distante y “muy técnico” // hipersensible al
  sufrimiento ajeno, complaciente, busca “agradar”.
•       -Profesional inseguro- reduccionista- evitador // hiperseguro,
  resolutivo.
• Rasgos que limitan o sesgan el razonamiento.-
•       -Profesional altamente atributivo, culpabilizador, testarudo.
•       -Profesional altamente defensivo, autoritario o paternalista
•       -Profesional irónico- egodistónico- solipsista
•       -Profesional «ansioso-asegurador», temeroso, obsesivo.


    Borrell-Carrio F, Epstein RM, Pardell H.. Profesionalidad y professionalism:
    Fundamentos, contenidos, praxis y docencia
     Med Clin (Barc). 2006;127(9):337-42
DISPOSICIONES AFECTIVAS, ACTITUDINALES/
         CARACTERIALES Y COGNITIVAS.
• COGNITIVAS:
•      *FALTA DE CONOCIMIENTOS/RECONOCIMIENTO
•      *HEURISTICOS Y/O CRITERIOS ERRÓNEOS
•      *RAZONAMIENTO
•             Desenfocado: Inadecuado para la situación.
•             Intolera “no saber”: Precipita cierre entrevista.
•             Pereza de reacción: Inercia diagnóstica.
•             Baja productividad ideativa
•             Confirmatorio:
•                       Dependencia de otros.
•                       Banaliza los síntomas/signos del paciente.


•
DISPOSICIONES COGNITIVAS (i)
(Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine
                                               2003; 78(8): 775-780)

  •    Aggregate bias: when physicians believe that aggregated data, such as those used to develop clinical practice guidelines, do not apply
       to individual patients (especially their own), they are invoking the aggregate fallacy. The belief that their patients are atypical or
       somehow exceptional may lead to errors of commission, e.g., ordering x-rays or other tests when guidelines indicate none are
       required.
  •    Anchoring: the tendency to perceptually lock onto salient features in the patient’s initial presentation too early in the diagnostic
       process, and failing to adjust this initial impression in the light of later information. This CDR may be severely compounded by the
       confirmation bias. Ascertainment bias: occurs when a physician’s thinking is shaped by prior expectation; stereotyping and gender
       bias are both good examples.
  •    Availability: the disposition to judge things as being more likely, or frequently occurring, if they readily come to mind. Thus, recent
       experience with a disease may inflate the likelihood of its being diagnosed. Conversely, if a disease has not been seen for a long time
       (is less available), it may be underdiagnosed.
  •    Base-rate neglect: the tendency to ignore the true prevalence of a disease, either inflating or reducing its base-rate, and distorting
       Bayesian reasoning. However, in some cases, clinicians may (consciously or otherwise) deliberately inflate the likelihood of disease,
       such as in the strategy of ‘‘rule out worst-case scenario’’ to avoid missing a rare but significant diagnosis.
  •    Commission bias: results from the obligation toward beneficence, in that harm to the patient can only be prevented by active
       intervention. It is the tendency toward action rather than inaction. It is more likely in over-confident physicians. Commission bias is
       less common than omission bias.
  •    Confirmation bias: the tendency to look for confirming evidence to support a diagnosis rather than look for disconfirming evidence
       to refute it, despite the latter often being more persuasive and definitive.
  •    Diagnosis momentum: once diagnostic labels are attached to patients they tend to become stickier and stickier. Through
       intermediaries (patients, paramedics, nurses, physicians), what might have started as a possibility gathers increasing momentum until
       it becomes definite, and all other possibilities are excluded.
  •    Feedback sanction: a form of ignorance trap and time-delay trap CDR. Making a diagnostic error may carry no immediate
       consequences, as considerable time may elapse before the error is discovered, if ever, or poor system feedback processes prevent
       important information on decisions getting back to the decision maker. The particular CDR that failed the patient persists because of
       these temporal and systemic sanctions.
  •    Framing effect: how diagnosticians see things may be strongly influenced by the way in which the problem is framed, e.g.,
       physicians’ perceptions of risk to the patient may be strongly influenced by whether the outcome is expressed in terms of the
       possibility that the patient might die or might live. In terms of diagnosis, physicians should be aware of how patients, nurses, and
       other physicians frame potential outcomes and contingencies of the clinical problem to them.
DISPOSICIONESCOGNITIVAS (ii)
               DISPOSICIONES COGNITIVAS (ii)
(Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine
                                               2003; 78(8): 775-780)
   •   Fundamental attribution error: the tendency to be judgmental and blame patients for their illnesses (dispositional causes) rather
        than examine the circumstances (situational factors) that might have been responsible. In particular, psychiatric patients, minorities, and
        other marginalized groups tend to suffer from this CDR. Cultural differences exist in terms of the respective weights attributed to
        dispositional and situational causes.
   •    Gambler’s fallacy: attributed to gamblers, this fallacy is the belief that if a coin is tossed ten times and is heads each time, the 11th toss
        has a greater chance of being tails (even though a fair coin has no memory). An example would be a physician who sees a series of patients
        with chest pain in clinic or the emergency department, diagnoses all of them with an acute coronary syndrome, and assumes the sequence
        will not continue. Thus, the pretest probability that a patient will have a particular diagnosis might be influenced by preceding but
        independent events.
   •    Gender bias: the tendency to believe that gender is a determining factor in the probability of diagnosis of a particular disease when no
        such pathophysiological basis exists. Generally, it results in an overdiagnosis of the favored gender and underdiagnosis of the neglected
        gender.
   •    Hindsight bias: knowing the outcome may profoundly influence the perception of past events and prevent a realistic appraisal of what
        actually occurred. In the context of diagnostic error, it may compromise learning through either an underestimation (illusion of failure) or
        overestimation (illusion of control) of the decision maker’s abilities.
   •    Multiple alternatives bias: a multiplicity of options on a differential diagnosis may lead to significant conflict and uncertainty. The
        process may be simplified by reverting to a smaller subset with which the physician is familiar but may result in inadequate consideration
        of other possibilities. One such strategy is the three-diagnosis differential: ‘‘It is probably A, but it might be B, or I don’t know (C).’’
        Although this approach has some heuristic value, if the disease falls in the C category and is not pursued adequately, it will minimize the
        chances that some serious diagnoses can be made.
   •    Omission bias: the tendency toward inaction and rooted in the principle of nonmaleficence. In hindsight, events that have occurred
        through the natural progression of a disease are more acceptable than those that may be attributed directly to the action of the physician.
        The bias may be sustained by the reinforcement often associated with not doing anything, but it may prove disastrous. Omission biases
        typically outnumber commission biases.
   •    Order effects: information transfer is a U-function: we tend to remember the beginning part (primacy effect) or the end
        (recency effect). Primacy effect may be augmented by anchoring. In transitions of care, in which information transferred from patients,
        nurses, or other physicians is being evaluated, care should be taken to give due consideration to all information, regardless of the order in
        which it was presented.
   •    Outcome bias: the tendency to opt for diagnostic decisions that will lead to good outcomes, rather than those associated with bad
        outcomes, thereby avoiding chagrin associated with the latter. It is a form of value bias in that physicians may express a stronger likelihood
        in their decision-making for what they hope will happen rather than for what they really believe might happen. This may result in serious
DISPOSICIONES COGNITIVAS (iii)
          DISPOSICIONES COGNITIVAS(iii)
(Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine
                                               2003; 78(8): 775-780)



   •    Overconfidence bias: a universal tendency to believe we know more than we do. Overconfidence reflects a tendency to act on incomplete
        information, intuitions, or hunches. Too much faith is placed in opinion instead of carefully gathered evidence. The bias may be augmented
        by both anchoring and availability, and catastrophic outcomes may result when there is a prevailing commission bias.
   •    Playing the odds: (also known as frequency gambling) is the tendency in equivocal or ambiguous presentations to opt for a benign
        diagnosis on the basis that it is significantly more likely than a serious one. It may be compounded by the fact that the signs and symptoms
        of many common and benign diseases are mimicked by more serious and rare ones. The strategy may be unwitting or deliberate and is
        diametrically opposed to the rule out worst-case scenario strategy (see base-rate neglect).
   •    Posterior probability error : occurs when a physician’s estimate for the likelihood of disease is unduly influenced by what has gone on
        before for a particular patient. It is the opposite of the gambler’s fallacy in that the physician is gambling on the sequence continuing, e.g.,
        if a patient presents to the office five times with a headache that is correctly diagnosed as migraine on each visit, it is the tendency to
        diagnose migraine on the sixth visit.Common things for most patients continue to be common, and the potential for a nonbenign headache
        being diagnosed is lowered through posterior probability.
   •    Premature closure: a powerful CDR accounting for a high proportion of missed diagnoses. It is the tendency to apply premature closure to
        the decisionmaking process, accepting a diagnosis before it has been fully verified. The consequences of the bias are reflected in the
        maxim: ‘‘When the diagnosis is made, the thinking stops.’’
   •    Psych-out error : psychiatric patients appear to be particularly vulnerable to the CDRs described in this list and to other errors in their
        management, some of which may exacerbate their condition. They appear especially vulnerable to fundamental attribution error. In
        particular, comorbid medical conditions may be overlooked or minimized. A variant of psych-out error occurs when serious medical
        conditions (e.g., hypoxia, delerium, metabolic abnormalities, CNS infections, head injury) are misdiagnosed as psychiatric conditions.
   •    Representativeness restraint: the representativeness heuristic drives the diagnostician toward looking for prototypical manifestations of
        disease: ‘‘If it looks like a duck, walks like a duck, quacks like a duck, then it is a duck.’’ Yet restraining decision-making along these pattern-
        recognition lines leads to atypical variants being missed.
   •    Search satisfying : reflects the universal tendency to call off a search once something is found. Comorbidities, second foreign bodies, other
        fractures, and coingestants in poisoning may all be missed. Also, if the search yields nothing, diagnosticians should satisfy themselves that
        they have been looking in the right place.
DISPOSICIONES COGNITIVAS (iv)
          DISPOSICIONES COGNITIVAS(iv)
(Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine
                                               2003; 78(8): 775-780)



   •    Sutton’s slip: takes its name from the apocryphal story of the Brooklyn bank-robber Willie Sutton who, when asked by the Judge why he
        robbed banks, is alleged to have replied: ‘‘Because that’s where the money is!’’ The diagnostic strategy of going for the obvious is referred
        to as Sutton’s law. The slip occurs when possibilities other than the obvious are not given sufficient consideration.
   •    Sunk costs: the more clinicians invest in a particular diagnosis, the less likely they may be to release it and consider alternatives. This is an
        entrapment form of CDR more associated with investment and financial considerations. However, for the diagnostician, the investment is
        time and mental energy and, for some, ego may be a precious investment. Confirmation bias may be a manifestation of such an
        unwillingness to let go of a failing diagnosis.
   •    Triage cueing : the triage process occurs throughout the health care system, from the self-triage of patients to the selection of a specialist
        by the referring physician. In the emergency department, triage is a formal process that results in patients being sent in particular
        directions, which cues their subsequent management. Many CDRs are initiated at triage, leading to the maxim: ‘‘Geography is destiny.’’
   •    Unpacking principle : failure to elicit all relevant information (unpacking) in establishing a differential diagnosis may result in significant
        possibilities being missed. The more specific a description of an illness that is received, the more likely the event is judged to exist. If
        patients are allowed to limit their history-giving, or physicians otherwise limit their history-taking, unspecified possibilities may be
        discounted.
   •    Vertical line failure: routine, repetitive tasks often lead to thinking in silos—predictable, orthodox styles that emphasize economy, efficacy,
        and utility. Though often rewarded, the approach carries the inherent penalty of inflexibility. In contrast, lateral thinking styles create
        opportunities for diagnosing the unexpected, rare, or esoteric. An effective lateral thinking strategy is simply to pose the question: ‘‘What
        else might this be?’’
   •    Visceral bias : the influence of affective sources of error on decision-making has been widely underestimated. Visceral arousal leads to
        poor decisions.
   •    Countertransference, both negative and positive feelings toward patients, may result in diagnoses being missed. Some attribution
        phenomena (fundamental attribution error) may have their origin in countertransference.
   •    Yin-Yang out : when patients have been subjected to exhaustive and unavailing diagnostic investigations, they are said to have been
        worked up the Yin-Yang. The Yin-Yang out is the tendency to believe that nothing further can be done to throw light on the dark place
        where, and if, any definitive diagnosis resides for the patient, i.e., the physician is let out of further diagnostic effort. This may prove
        ultimately to be true, but to adopt the strategy at the outset is fraught with the chance of a variety of errors.
ESTRATEGIAS DE MEJORA


• EL PROFESIONAL

• EL SISTEMA
ESTRATEGIAS DE MEJORA: EL
           PROFESIONAL.
• FORMAR
  – Patrones de reconocimiento de trastornos/
    enfermedades y sus complicaciones.
  – Script de los trastornos/enfermedades.
  – Situaciones de alarma.
• COMPARTIR
  – Experiencias clínicas.
  – Asesoramiento/tutorización directa.
• DAR FEEDBACK
Propósito                  Asunción                 Insuficiencias Enfoque
FORMACION
Metacognición     Hábitos                    Conductas                Caro                Individuo
                                             mas
                                             complejas
Experteza         Conocimientos              Reconocer                Caro                Individuo



COMPARTIR
En línea          Validar                    Amplia opciones          No inmediato        Individuo
                  Sugerir otros
                  Diagn.
Segunda opinión   Idem                       Compartir criterios      Solo casos          Equipo
                                                                      “especiales”
Sistema experto   Sugerir                    Exhaustividad            Solo casos          Individuo
                                                                      “especiales”
Participación
paciente

FEEDBACK
Autopsias         Mejorar experiencia clínica Relacionar síntomas y Caro, solo casos       Equipo
                                              signos con diag no    “especiales”,
                                              obvios                resistencia familiares


Audit             Mejorar procedimientos     Disciplina trabajo       Nexo no bien        Individuo /
                                             conlleva mejores         establecido         Equipo
                                             resultados


Seguimiento       Rectificar                 Ganar en flexibilidad;   Exige planificar.   Individuo /
                                             Evitar error o                               Equipo
                                             disminuir efectos.
ESTRATEGIAS DE MEJORA: EL SISTEMA.
• MEJORAR EL RESCATE DE INFORMACION.
• MEJORAR LA COMUNICACIÓN ENTRE
  PROFESIONALES Y EL ACCESO A PRUEBAS.
• SISTEMAS EXPERTOS
• ALERTAS
• TAREAS PENDIENTES
• GESTION DE POBLACIONES A RIESGO
HISTORIA CLÍNICA
   ELECTRÓNICA
• TAPIZ
  – LISTA PROBLEMAS
  – CURSO CLÍNICO
     • PROBLEMAS/EPISODIOS
  – PRESCRIPCIONES
  – HOJA MONITORIZACIÓN, HISTORICO DE PRUEBAS…
• INTERCONECTIVIDAD
  – PRUEBAS COMPLEMENTARIAS
  – HISTORIA CLINICA ELECTRONICA
  – CURSOS CLÍNICOS OTROS PROFESIONALES.
ALERTAS
                  •   ANALITICAS /RADIOLOGIA
EN EL MOMENTO
DE LA CONEXION    •   ALTAS HOSPITALARIAS/URGENCIAS
                  •   INTERCONSULTAS ESPECIALISTAS
                  •   DEFUNCIONES

DURANTE EL ACTO   • PREASEG
CLÍNICO
                  • TAREAS PENDIENTES
PERFIL PRESCRIPCION
 • ON TIME (PREFASEG):
   –   INTERACCIONES.
   –   REDUNDANCIAS (DUPLICADOS)
   –   EDADES EXTREMAS
   –   ENFERMEDADES/CONDICIONES DEL PACIENTE
   –   REACCIONES ADVERSAS /ALERGIAS
   –   TUTOR PEDIATRIA
 • OFF TIME (SELF AUDIT):
   – REDUNDANCIAS (DUPLICADOS).
   – MAS DE 10 FÀRMACOS
   – NO RECOMENDADOS POR EDAD/ PROTECCIÓN
     GÀSTRICA, ETC.
GESTION DE
POBLACIONES A RIESGO
 • OFF TIME
   –   EPOC.
   –   DIABETICOS
   –   RIESGO CARDIOVASCULAR
   –   OTROS…
 • EN UN FUTURO
   – POBLACION DE ESPECIAL SEGUIMIENTO:
        • DEFINIDO POR VARIOS FACTORES
        • DEFINIDO POR EL PROFESIONAL
   – POBLACION DETECTADA POR SISTEMAS EXPERTOS.
        • VARIABLES BIOLOGICAS
        • VARIABLES PSICOSOCIALES
Prescripción Farmacológica Segura
                 PREFASEG
        Autores: CAMFiC i ICS
       Ester Amado                        Arantxa Catalán
                                          Leonardo Galván
       Jose Miguel Baena
                                          Vicente Morales
       Gladys Bendahan                    Míriam Oms
       Francesc Borrell                   Àngels Pons

      Con la colaboración de:
       Fundació Avedis Donabedian
       Subdirecció General de Recursos Sanitaris

Financiación: Aliança per la Seguretat dels Pacients (Departament de Salut, 2007)
     Ministerio de Sanidad y Política Social (Seguridad de pacientes, 2009)
PARA SABER MAS
• Aranaz JM, Aibar C, Vitaller J, Mira JJ Gestión Sanitaria. Calidad y
  Seguridad de los pacientes. Fundación MAPFRE. Diaz de Santos,
  Madrid 2008.
• Baron J. Thinking and Deciding. 3rd ed. Cambridge, UK:
• Cambridge University Press; 2003.
• Gigerenzer G. Simple Heuristics that Make Us Smart. Oxford, UK:
  Oxford University Press; 1999.
• Kassirer JP, Kopelman RI. Learning Clinical Reasoning.
• Baltimore, MD: Williams & Wilkins; 1991.
• Godoy A. Toma de decisiones y juicio clínico. Piramide. Madrid
  1996.
• Dowie JU, Elstein A. Professional judgement. A reader in clinical
  decision making. Cambridge University Press. New York 1988
PARA SABER MAS
•   Society of Medical Decision Making (available at: http://www.smdm.org
•
•   The Brunswik Society (available at: http://www.brunswik.org )

•   Decision Analysis Society (available at: http://faculty.fuqua.duke.edu/daweb )

•   Society for Judgment and Decision Making (available at: http://www.sjdm.org)

•   Center for Adaptive Behavior and Cognition (available at:
•   http://www.mpib-berlin.mpg.de/en/research/adaptive-behavior-and-cognition

•   AHRQ Web M&M, October 2007. Available at: http://www.webmm.ahrq.gov/index.aspx
MUCHAS GRACIAS POR VUESTRA
        ATENCION

          NOS VEMOS EN:
   www.humedicas.blogspot.com
  www.seguridadclinica.blogspot.com

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IV Jornada. Sp y práctica reflexiva f borrell_pompeu fabra_2011

  • 1. SEGURIDAD CLINICA Y PRACTICA CLINICA REFLEXIVA Francesc Borrell i Carrió. Profesor Titular de MFC, Facultad Medicina, Universidad Barcelona, Departament de Ciències Clíniques. EAP Gavarra. ICS Email.- 12902fbc@comb.cat
  • 2. CONTENIDOS Introducción.- Modelo centrado en el paciente. Self awareness. El acto clínico.- Lo que sabemos -Estudios epidemiológicos. -Estudios de performance, (Pacientes Incógnito). Estrategias de mejora. El profesional El sistema. -Prefaseg.
  • 3. VALORES CLAVE DEL MODELO • AFLORAR: necesidades, perspectiva y valores del paciente. • COMPARTIR: decisiones, comprensión. • CONSTRUIR: una relación empática y sensible (responsiveness).
  • 4. MODELO CENTRADO EN EL PACIENTE TAREAS EN LA ENTREVISTA. • FASE EXPLORATORIA: – El paciente puede hablar. Ocupación verbal. – Más allá del síntoma aparece la persona: • Creencias, ilusiones, expectativas, miedos… • FASE RESOLUTIVA: – El paciente puede participar: • En la definición de su problema. • En el plan de actuación.
  • 5. PRACTICA CLINICA REFLEXIVA. • ME OBSERVO: – En el “ahora”, sin idealizarme, escuchando mis emociones que me advierten de peligros. • REFLEXION EN LA ACCION: – Escuchamos y exploramos para crearnos una imagen del paciente. Independencia de criterio. – Integro los datos en la persona: • Terreno biológico, contexto psicosocial. • REFLEXION FUERA DE LA CONSULTA: – Gestión poblacional. Prevención. – Gestión individual: • Pongo al paciente en mi agenda. • Comparto con el equipo.
  • 6. ¿Aporta algo que no nos aporte el enfoque sistémico? Acciones claras y muchas veces simples. Accountability. Políticas organizacionales.
  • 7. ESTUDIOS INTERNACIONALES • Leape L, Brennan TA, Laird N, et al. The nature of adverse events in hospitalized patients: results of the Harvard Medical Practice Study II. N Engl J Med. 1991;324:377– 384. • Wilson RM, Harrison BT, Gibberd RW, Hamilton JD. An analysis of the causes of adverse events from the Quality in Australian Health Care Study. Med J Aust. 1999;170:411– 415. • Bhasale A, Miller G, Reid S, Britt HC. Analyzing potential harm in Australian general practice: an incident-monitoring study. Med J Aust. 1998;169:73–76. • Thomas EJ, Studdert DM, Burstin HR, et al. Incidence and types of adverse events and negligent care in Utah and Colorado. Med Care. 2000;38:261–271. • Baker GR, Norton PG, Flintoft V, et al. The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada. CMAJ. 2004;170:1678 –1686. • Davis P, Lay-Yee R, Briant R, Ali W, Scott A, Schug S. Adverse events in New Zealand public hospitals II: preventability and clinical context. N Z Med J. 2003;116:U624.
  • 8. ERROR MEDICO ENEAS 9,3% (525/5.624); IC95%: 8,6% - 10,1% INGRESOS • Toma de datos. • Medicación: 37,4% • Infecciones nosocomiales 25,3% • Diagnósticos. • • Problemas técnicos Diagnóstico 25,0% 2,75% • Tratamiento. APEAS CONSULTAS 11,18‰ (IC95%: 10,52 - 11,85). • Medicación: 48,2% • Seguimiento. • Cuidados 25,7% • Comunicación 24,6% • Diagnóstico 13,1% • Gestión 8,9% • Otros 14,4% IBEAS, (10,5% EA) OTROS.- Jesús María Aranaz Andrés
  • 9. TOTAL Moderados- graves Eventos 47,7% 30,0%-5,7% adversos relacionados conla medicación RAM 59,1% 66,1% evitables
  • 10. LO QUE NO PUEDE VER EL APEAS • Errores en la comunicación y relación asistencial. • Desacierto diagnóstico o falta de diagnóstico sin consecuencias inmediatas y no percibido por informante. • Omisión de maniobras diagnósticas, terapéuticas o preventivas. • Falta de seguimiento.
  • 11. INCLUSO CUANDO TENEMOS SISTEMA DE NOTIFICACION CONFIDENCIAL…. Muchos errores diagnósticos no se detectan como EA: • “La mayor parte de errores diagnosticos prevenibles no se informan a través de los medios de notificación voluntario”. Fischer G, Fetters MD, Munro AP, Goldman EB. Adverse events in primary care identified from a risk-management database. J Fam Pract. 1997;45:40–46 • Ninguno de los errores de diagnóstico que revelaron los residentes había sido informado a las base de datos. • Weingart S, Ship A, Aronson M. Confidential clinical-reported surveillance of adverse events among medical inpatients. J Gen Intern Med. 2000;15:470–477.
  • 12. “NEGACIONISMO” • El 28% eran “negadores”(I.C95%: 22.34-34.26), • 67 % “perceptivos” (I.C95%: 60.79-73.23), • 7.4% “hiperperceptivos” (I.C95%: 4.41-11.44), • 6% “locus interno”(I.C95%: 3.34-9.91), • 23.4 % hiperseguros(I.C95%: 18.14-29.22). • Se informó sobre 10.6 acontecimientos adversos/año/profesional, sobretodo eventos adversos de fármacos (37%)(I.C95%: 35.36-39.15) , y retraso diagnóstico en patología neoplásica (33%) (I.C95%: 31.16-34.85). Borrell F, Paez C, Suñol R, Orrego C, Gil N, Marti M Errores clínicos y eventos adversos: p ercepción de los médicos de atención primaria. Aten Primaria 2006; 38(1):25-32 Solo 1% admite públicamente haberse equivocado en el último año. Berner ES, Graber ML Overconfidence as a Cause of Diagnostic Error in Medicine The American Journal of Medicine (2008) Vol 121 (5A), S2–S23
  • 13. Graber ML. 5 años, 3 centros, 100 casos de error diagnóstico. • *Sistémicos: fallos tecnológicos, mala organización. 65% • *No error: falta colaboración paciente, presentación atípica 44% • *Cognitivos: falta de conocimiento, toma de datos, sintesis de datos. 74% • Dentro de los cognitivos: • Falta de conocimientos 11 ocasiones • Falta de datos tomados del paciente: 45 • Falta de procesamiento adecuado de la información 159 • Falta de verificación 106 • CAUSA PROFUNDA: CIERRE PRECIPITADO Graber ML, Franklin N, Gordon RR. Diagnostic error in internal medicine. Arch Intern Med. 2005;165:1493–1499.
  • 14. “Error diagnóstico” • “Diagnostic error”: retraso no intencionado (existía suficiente información previa), equivocado(otro diagnóstico se realizó antes del correcto), o no presente (no se realizó diagnóstico), desde la perspectiva de una información final mas definitiva. Graber ML, Franklin N, Gordon RR. Diagnostic error in internal medicine. Arch Intern Med. 2005;165:1493–1499.
  • 15. Errores por especialidades • -Especialidades perceptivas: radiologia 5%, A Patologica <5%, Dermatologia 11%. • -Especialidades médicas 10-15%. • -Superior en urgencias y entornos de alta densidad de decisiones. Berner ES, Graber ML Overconfidence as a Cause of Diagnostic Error in Medicine The American Journal of Medicine (2008) Vol 121 (5A), S2–S23
  • 16. Errores por patologias Entidad % Cometarios Aneurisma Aorta 35% Precordialgias, 1era evaluacion sin diag. Hemorragia subaracn 30% 1era. evaluacion sin diagnóstico Mamografia Ca mama 21% 1era. lectura con error T. Bipolar 69% Diagnóstico inicial incorrecto Artr. Psoriásica 39% 1era vista reumatólogo no diagn. Diabetes Mellitus 18% No consta diagnóstico en HC Lectura Radiografias 30% Errores cuando leídas en consulta (no radiólogo).
  • 17. EL ENFOQUE SISTEMICO DEBE AFRONTAR UNA REALIDAD INCOMODA LA PERSONA ES PARTE DEL SISTEMA
  • 18. EL MEDICO COMO CAJA NEGRA datos Decisiones Actos
  • 19. EL MEDICO COMO CAJA NEGRA • FALIBILIDAD. • MEJOR EFICIENCIA. – Curva de rendimiento. • MANTENIMIENTO • “OXIDACION” ¡SI AL MENOS SE NOS CONSIDERARA COMO UNA MÁQUINA!
  • 20. ¿COMO APROXIMARNOS A ESTA INCOMODA REALIDAD? ESTUDIOS DE LABORATORIO ESTUDIOS EN LAS CONDICIONES NATURALES DEL PROFESIONAL
  • 21. ESTUDIOS NIVEL 4 PIRAMIDE DE MILLER
  • 22. PACIENTE ESTANDARIZADO Y ENMASCARADO PREPARACION VISITA CON AUDIOGRABACION ENMASCARAMIENTO RECUPERACION SALA ESPERA DE DATOS – ENCUESTA
  • 23. ESTUDIOS ESPAÑOLES • Suñol R: Correlación entre los procesos y los resultados de la Entrevista Clínica: su aplicación a los programas de calidad en Atención Primaria. Tesis Doctoral, Universidad Autónoma de Barcelona. Barcelona, 1992 • Prados Castillejo, JA. Distorsión en las Técnicas Comunicacionales (Entrevista Clínica) en las consultas de Demanda de Atención Primaria. Tesis Doctoral. Universidad de Córdoba. Facultad de Medicina. Departamento de Medicina. Córdoba 1996 . • Barragán N, Violan C, Martín Cantera C, Ferrer-Vidal D, González-Algas J. Diseño de un método para la evaluación de la competencia clínica en atención primaria Aten Primaria. 2000 Nov 30;26(9):590-4.
  • 24. ESTUDIOS ESPAÑOLES • Borrell F.,Fontova B, Muñoz E, Prados JA, Pedregal M, Peguero E. Physician s ability to find a physical sign (hepatomegaly). European Journal Gen Pract 2011. • Llor C, Cots JM. The sale of antibiotics without prescription in pharmacies in Catalonia, Spain.Clin Infect Dis. 2009 May 15;48(10):1345-9.
  • 25. ESTUDIOS INTERNACIONALES • 46 TRABAJOS, 24 EN LOS ÚLTIMOS 5 AÑOS. 1.-McLeod PJ, et al. Use of standardized patients to assess between-physician variations in resource utilization JAMA. 1997 Oct 8;278(14):1164-8 2.-Dresselhaus TR, et al The ethical problem of false positives: a prospective evaluation of physician reporting in the medical record J Med Ethics. 2002 Oct;28(5):291-4 3.- Rethans jj, Sturmans F, Drop R, Van der Vleuten c, Hobus P. Does competence of general practitioners predict their performance? Comparison between examination setting and actual practices BMJ 1991 Nov 30;303(6814):1377 4.-.- Suñol R: Correlación entre los procesos y los resultados de la Entrevista Clínica: su aplicación a los programas de calidad en Atención Primaria. Tesis Doctoral, Universidad Autónoma de Barcelona. Barcelona, 1992 5.- Borrell F.,Fontova B, Muñoz E, Prados JA, Pedregal M, Peguero E. Physician s ability to find a physical sign (hepatomegaly). European J Gen Pract 2011. 6.-Franz CE, Epstein R, Miller KN, Brown A, Song J, Feldman M, Franks P, Kelly-Reif S, Kravitz RL. Caught in the act? Prevalence, predictors, and consequences of physician detection of unannounced standardized patients. Health Serv R 7.-Gallagher TH, Lo B, Chesney M, Christensen K. How do physicians respond to patient's requests for costly, unindicated services? J Gen Intern Med. 1997 Nov;12(11):663-8. 8.-Kravitz RL, Epstein RM, Feldman MD, Franz CE, Azari R, Wilkes MS, Hinton L, Franks P. Influence of patients' requests for direct-to-consumer advertised antidepressants: a randomized controlled trial. JAMA. 2005 Apr 27;293(16):1995-2002. 9.-Brown JA, Abelson J, Woodward CA, Hutchison B, Norman G. Fielding standardized patients in primary care settings: lessons from a study using unannounced standardized patients to assess preventive care practices. Int J Qual Hea 10.-Zabar S, Ark T, Gillespie C, Hsieh A, Kalet A, Kachur E, Manko J, Regan L. Can unannounced standardized patients assess professionalism and communication skills in the emergency department? Acad Emerg Med. 2009 Sep;16(9):9 11.-Epstein RM, Levenkron JC, Frarey L, Thompson J, Anderson K, Franks P. Improving physicians' HIV risk-assessment skills using announced and unannounced standardized patients. J Gen Intern Med. 2001 Mar;16(3):176 12.-Srinivasan M, Franks P, Meredith LS, Fiscella K, Epstein RM, Kravitz RL. Connoisseurs of care? Unannounced standardized patients' ratings of physicians. Med Care. 2006 Dec;44(12):1092-8. 13.- Fiscella K, Franks P, Srinivasan M, Kravitz RL, Epstein R. Ratings of physician communication by real and standardized patients. Ann Fam Med. 2007 Mar-Apr;5(2):151-8. 14.- Ozuah PO, Reznik M. Residents' asthma communication skills in announced versus unannounced standardized patient exercises. Ambul Pediatr. 2007 Nov-Dec;7(6):445-8. 15.- Barragán N, Violan C, Martín Cantera C, Ferrer-Vidal D, González-Algas J. Diseño de un método para la evaluación de la competencia clínica en atención primaria Aten Primaria. 2000 Nov 30;26(9):590-4. 16.- Prados Castillejo, JA. Distorsión en las Técnicas Comunicacionales (Entrevista Clínica) en las consultas de Demanda de Atención Primaria. Tesis Doctoral. Universidad de Córdoba. Facultad de Medicina. Departamento de Medicina. 17.-Krane NK, Anderson D, Lazarus CJ, Termini M, Bowdish B, Chauvin S, Fonseca V. Physician practice behavior and practice guidelines: using unannounced standardized patients to gather data. J Gen Intern Med. 2009 Jan;24(1):53-6. Epub 2008 Oct 31. 18.- Feldman MD, Franks P, Duberstein PR, Vannoy S, Epstein R, Kravitz RL. Let's not talk about it: suicide inquiry in primary care. Ann Fam Med. 2007 Sep-Oct;5(5):412-8. 19. Epstein RM, Shields CG, Meldrum SC, Fiscella K, Carroll J, Carney PA, Duberstein PR. Physicians' responses to patients' medically unexplained symptoms. Psychosom Med. 2006 Mar-Apr;68(2):269-76. 20. Seaburn DB, Morse D, McDaniel SH, Beckman H, Silberman J, Epstein R. Physician responses to ambiguous patient symptoms. J Gen Intern Med. 2005 Jun;20(6):525-30. 21.- Peabody JW, Luck J, Jain S, Bertenthal D, Glassman P. Assessing the accuracy of administrative data in health information systems. Med Care. 2004 Nov;42(11):1066-72. 22. Carney PA, Dietrich AJ, Eliassen MS, Owen M, Badger LW. Recognizing and managing depression in primary care: a standardized patient study. J Fam Pract. 1999 Dec;48(12):965-72. 23.-Kravitz RL, Franks P, Feldman M, Meredith LS, Hinton L, Franz C, Duberstein P, Epstein RM. What drives referral from primary care physicians to mental health specialists? A randomized trial using actors portraying depressive sym 24.- Woodward CA, Hutchison B, Norman GR, Brown JA, Abelson J. What factors influence primary care physicians' charges for their services? An exploratory study using standardized patients. CMAJ. 1998 Jan 27;158(2):197-202. 25.- Rethans JJ, Saebu L. Do general practitioners act consistently in real practice when they meet the same patient twice? Examination of intradoctor variation using standardised (simulated) patients. BMJ. 1997 Apr 19;314(7088):1
  • 26. RESUMEN DE ESTOS TRABAJOS Fiabilidad, validez, detección o sospecha del paciente, factibilidad y satisfacción del profesional.
  • 27. ASPECTOS GENERALES • PSI mejor método para analizar acto asistencial. • Competencia y Performance son diferentes. • Historia Clínica (notas clínicas) poco fiables para juzgar calidad. • El Paciente Problema inhibe habilidades de anamnesis. • Gran esfuerzo para gestionar el tiempo. • Las expectativas del paciente marcan diferentes “finales”.
  • 28. SITUEMOS ESTOS HALLAZGOS EN UN MODELO Borrell-Carrió F. Epstein R Preventing errors in clinical practice: a call for self- awareness Ann Fam Med 2004;2(4):310-316.
  • 29. ¿COMO LLEGAMOS A UN DIAGNÓSTICO? SITUACIÓN- PRIMERAS ESTÍMULAR: HIPÒTESIS INTENCIONALIDAD REENCUADRE CONDUCTAS VERIFICACIÓN COLAPSO COGNITIVO CONDICIONES DE SUFICIENCIA “OFERTA” QUE HAREMOS AL PACIENTE
  • 30. CAPACIDAD VERSUS DISPOSICION. • CAPACIDAD: COMPETENCIA, NIVEL 3. “GENOTIPO”. • DISPOSICIÓN: PERFORMANCE, NIVEL 4. “FENOTIPO”. FACTORES RESTRICTIVOS • CAPACIDAD : LO QUE SOY CAPAZ DE HACER • PERCEPTIVA, AHORA Y AQUÍ • COGNITIVA, • CONDUCTUAL.
  • 31. DISPOSICIONES AFECTIVAS, ACTITUDINALES/ CARACTERIALES Y COGNITIVAS. • AFECTIVAS: • ESTADOS TRANSITORIOS: cansancio, ruido, calor o frío, hiperestimulación sensorial, deprivación sueño, etc. • SITUACION CLINICA: agresividad, contra- transferencia, atribuciones… • SITUACION AFECTIVA ENDOGENA: trastorno del humor, de ansiedad, trastornos ciclotímicos, circadianos, etc. Pat Croskerry, Allan A Abbass, Albert W Wu How doctors feel: aff ective issues in patients’ safety The Lancet Vol 372 October 4, 2008 1205-6
  • 32. DISPOSICIONES AFECTIVAS, ACTITUDINALES/ CARACTERIALES Y COGNITIVAS. • ACTITUDINALES / CARACTERIALES: • Rasgos polares que limitan o sesgan la percepción y o el razonamiento.- • -Profesional frío, distante y “muy técnico” // hipersensible al sufrimiento ajeno, complaciente, busca “agradar”. • -Profesional inseguro- reduccionista- evitador // hiperseguro, resolutivo. • Rasgos que limitan o sesgan el razonamiento.- • -Profesional altamente atributivo, culpabilizador, testarudo. • -Profesional altamente defensivo, autoritario o paternalista • -Profesional irónico- egodistónico- solipsista • -Profesional «ansioso-asegurador», temeroso, obsesivo. Borrell-Carrio F, Epstein RM, Pardell H.. Profesionalidad y professionalism: Fundamentos, contenidos, praxis y docencia Med Clin (Barc). 2006;127(9):337-42
  • 33. DISPOSICIONES AFECTIVAS, ACTITUDINALES/ CARACTERIALES Y COGNITIVAS. • COGNITIVAS: • *FALTA DE CONOCIMIENTOS/RECONOCIMIENTO • *HEURISTICOS Y/O CRITERIOS ERRÓNEOS • *RAZONAMIENTO • Desenfocado: Inadecuado para la situación. • Intolera “no saber”: Precipita cierre entrevista. • Pereza de reacción: Inercia diagnóstica. • Baja productividad ideativa • Confirmatorio: • Dependencia de otros. • Banaliza los síntomas/signos del paciente. •
  • 34. DISPOSICIONES COGNITIVAS (i) (Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine 2003; 78(8): 775-780) • Aggregate bias: when physicians believe that aggregated data, such as those used to develop clinical practice guidelines, do not apply to individual patients (especially their own), they are invoking the aggregate fallacy. The belief that their patients are atypical or somehow exceptional may lead to errors of commission, e.g., ordering x-rays or other tests when guidelines indicate none are required. • Anchoring: the tendency to perceptually lock onto salient features in the patient’s initial presentation too early in the diagnostic process, and failing to adjust this initial impression in the light of later information. This CDR may be severely compounded by the confirmation bias. Ascertainment bias: occurs when a physician’s thinking is shaped by prior expectation; stereotyping and gender bias are both good examples. • Availability: the disposition to judge things as being more likely, or frequently occurring, if they readily come to mind. Thus, recent experience with a disease may inflate the likelihood of its being diagnosed. Conversely, if a disease has not been seen for a long time (is less available), it may be underdiagnosed. • Base-rate neglect: the tendency to ignore the true prevalence of a disease, either inflating or reducing its base-rate, and distorting Bayesian reasoning. However, in some cases, clinicians may (consciously or otherwise) deliberately inflate the likelihood of disease, such as in the strategy of ‘‘rule out worst-case scenario’’ to avoid missing a rare but significant diagnosis. • Commission bias: results from the obligation toward beneficence, in that harm to the patient can only be prevented by active intervention. It is the tendency toward action rather than inaction. It is more likely in over-confident physicians. Commission bias is less common than omission bias. • Confirmation bias: the tendency to look for confirming evidence to support a diagnosis rather than look for disconfirming evidence to refute it, despite the latter often being more persuasive and definitive. • Diagnosis momentum: once diagnostic labels are attached to patients they tend to become stickier and stickier. Through intermediaries (patients, paramedics, nurses, physicians), what might have started as a possibility gathers increasing momentum until it becomes definite, and all other possibilities are excluded. • Feedback sanction: a form of ignorance trap and time-delay trap CDR. Making a diagnostic error may carry no immediate consequences, as considerable time may elapse before the error is discovered, if ever, or poor system feedback processes prevent important information on decisions getting back to the decision maker. The particular CDR that failed the patient persists because of these temporal and systemic sanctions. • Framing effect: how diagnosticians see things may be strongly influenced by the way in which the problem is framed, e.g., physicians’ perceptions of risk to the patient may be strongly influenced by whether the outcome is expressed in terms of the possibility that the patient might die or might live. In terms of diagnosis, physicians should be aware of how patients, nurses, and other physicians frame potential outcomes and contingencies of the clinical problem to them.
  • 35. DISPOSICIONESCOGNITIVAS (ii) DISPOSICIONES COGNITIVAS (ii) (Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine 2003; 78(8): 775-780) • Fundamental attribution error: the tendency to be judgmental and blame patients for their illnesses (dispositional causes) rather than examine the circumstances (situational factors) that might have been responsible. In particular, psychiatric patients, minorities, and other marginalized groups tend to suffer from this CDR. Cultural differences exist in terms of the respective weights attributed to dispositional and situational causes. • Gambler’s fallacy: attributed to gamblers, this fallacy is the belief that if a coin is tossed ten times and is heads each time, the 11th toss has a greater chance of being tails (even though a fair coin has no memory). An example would be a physician who sees a series of patients with chest pain in clinic or the emergency department, diagnoses all of them with an acute coronary syndrome, and assumes the sequence will not continue. Thus, the pretest probability that a patient will have a particular diagnosis might be influenced by preceding but independent events. • Gender bias: the tendency to believe that gender is a determining factor in the probability of diagnosis of a particular disease when no such pathophysiological basis exists. Generally, it results in an overdiagnosis of the favored gender and underdiagnosis of the neglected gender. • Hindsight bias: knowing the outcome may profoundly influence the perception of past events and prevent a realistic appraisal of what actually occurred. In the context of diagnostic error, it may compromise learning through either an underestimation (illusion of failure) or overestimation (illusion of control) of the decision maker’s abilities. • Multiple alternatives bias: a multiplicity of options on a differential diagnosis may lead to significant conflict and uncertainty. The process may be simplified by reverting to a smaller subset with which the physician is familiar but may result in inadequate consideration of other possibilities. One such strategy is the three-diagnosis differential: ‘‘It is probably A, but it might be B, or I don’t know (C).’’ Although this approach has some heuristic value, if the disease falls in the C category and is not pursued adequately, it will minimize the chances that some serious diagnoses can be made. • Omission bias: the tendency toward inaction and rooted in the principle of nonmaleficence. In hindsight, events that have occurred through the natural progression of a disease are more acceptable than those that may be attributed directly to the action of the physician. The bias may be sustained by the reinforcement often associated with not doing anything, but it may prove disastrous. Omission biases typically outnumber commission biases. • Order effects: information transfer is a U-function: we tend to remember the beginning part (primacy effect) or the end (recency effect). Primacy effect may be augmented by anchoring. In transitions of care, in which information transferred from patients, nurses, or other physicians is being evaluated, care should be taken to give due consideration to all information, regardless of the order in which it was presented. • Outcome bias: the tendency to opt for diagnostic decisions that will lead to good outcomes, rather than those associated with bad outcomes, thereby avoiding chagrin associated with the latter. It is a form of value bias in that physicians may express a stronger likelihood in their decision-making for what they hope will happen rather than for what they really believe might happen. This may result in serious
  • 36. DISPOSICIONES COGNITIVAS (iii) DISPOSICIONES COGNITIVAS(iii) (Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine 2003; 78(8): 775-780) • Overconfidence bias: a universal tendency to believe we know more than we do. Overconfidence reflects a tendency to act on incomplete information, intuitions, or hunches. Too much faith is placed in opinion instead of carefully gathered evidence. The bias may be augmented by both anchoring and availability, and catastrophic outcomes may result when there is a prevailing commission bias. • Playing the odds: (also known as frequency gambling) is the tendency in equivocal or ambiguous presentations to opt for a benign diagnosis on the basis that it is significantly more likely than a serious one. It may be compounded by the fact that the signs and symptoms of many common and benign diseases are mimicked by more serious and rare ones. The strategy may be unwitting or deliberate and is diametrically opposed to the rule out worst-case scenario strategy (see base-rate neglect). • Posterior probability error : occurs when a physician’s estimate for the likelihood of disease is unduly influenced by what has gone on before for a particular patient. It is the opposite of the gambler’s fallacy in that the physician is gambling on the sequence continuing, e.g., if a patient presents to the office five times with a headache that is correctly diagnosed as migraine on each visit, it is the tendency to diagnose migraine on the sixth visit.Common things for most patients continue to be common, and the potential for a nonbenign headache being diagnosed is lowered through posterior probability. • Premature closure: a powerful CDR accounting for a high proportion of missed diagnoses. It is the tendency to apply premature closure to the decisionmaking process, accepting a diagnosis before it has been fully verified. The consequences of the bias are reflected in the maxim: ‘‘When the diagnosis is made, the thinking stops.’’ • Psych-out error : psychiatric patients appear to be particularly vulnerable to the CDRs described in this list and to other errors in their management, some of which may exacerbate their condition. They appear especially vulnerable to fundamental attribution error. In particular, comorbid medical conditions may be overlooked or minimized. A variant of psych-out error occurs when serious medical conditions (e.g., hypoxia, delerium, metabolic abnormalities, CNS infections, head injury) are misdiagnosed as psychiatric conditions. • Representativeness restraint: the representativeness heuristic drives the diagnostician toward looking for prototypical manifestations of disease: ‘‘If it looks like a duck, walks like a duck, quacks like a duck, then it is a duck.’’ Yet restraining decision-making along these pattern- recognition lines leads to atypical variants being missed. • Search satisfying : reflects the universal tendency to call off a search once something is found. Comorbidities, second foreign bodies, other fractures, and coingestants in poisoning may all be missed. Also, if the search yields nothing, diagnosticians should satisfy themselves that they have been looking in the right place.
  • 37. DISPOSICIONES COGNITIVAS (iv) DISPOSICIONES COGNITIVAS(iv) (Croskerry P, The Importance of Cognitive Errors in Diagnosis and Strategies to Minimize Them , Academic Medicine 2003; 78(8): 775-780) • Sutton’s slip: takes its name from the apocryphal story of the Brooklyn bank-robber Willie Sutton who, when asked by the Judge why he robbed banks, is alleged to have replied: ‘‘Because that’s where the money is!’’ The diagnostic strategy of going for the obvious is referred to as Sutton’s law. The slip occurs when possibilities other than the obvious are not given sufficient consideration. • Sunk costs: the more clinicians invest in a particular diagnosis, the less likely they may be to release it and consider alternatives. This is an entrapment form of CDR more associated with investment and financial considerations. However, for the diagnostician, the investment is time and mental energy and, for some, ego may be a precious investment. Confirmation bias may be a manifestation of such an unwillingness to let go of a failing diagnosis. • Triage cueing : the triage process occurs throughout the health care system, from the self-triage of patients to the selection of a specialist by the referring physician. In the emergency department, triage is a formal process that results in patients being sent in particular directions, which cues their subsequent management. Many CDRs are initiated at triage, leading to the maxim: ‘‘Geography is destiny.’’ • Unpacking principle : failure to elicit all relevant information (unpacking) in establishing a differential diagnosis may result in significant possibilities being missed. The more specific a description of an illness that is received, the more likely the event is judged to exist. If patients are allowed to limit their history-giving, or physicians otherwise limit their history-taking, unspecified possibilities may be discounted. • Vertical line failure: routine, repetitive tasks often lead to thinking in silos—predictable, orthodox styles that emphasize economy, efficacy, and utility. Though often rewarded, the approach carries the inherent penalty of inflexibility. In contrast, lateral thinking styles create opportunities for diagnosing the unexpected, rare, or esoteric. An effective lateral thinking strategy is simply to pose the question: ‘‘What else might this be?’’ • Visceral bias : the influence of affective sources of error on decision-making has been widely underestimated. Visceral arousal leads to poor decisions. • Countertransference, both negative and positive feelings toward patients, may result in diagnoses being missed. Some attribution phenomena (fundamental attribution error) may have their origin in countertransference. • Yin-Yang out : when patients have been subjected to exhaustive and unavailing diagnostic investigations, they are said to have been worked up the Yin-Yang. The Yin-Yang out is the tendency to believe that nothing further can be done to throw light on the dark place where, and if, any definitive diagnosis resides for the patient, i.e., the physician is let out of further diagnostic effort. This may prove ultimately to be true, but to adopt the strategy at the outset is fraught with the chance of a variety of errors.
  • 38. ESTRATEGIAS DE MEJORA • EL PROFESIONAL • EL SISTEMA
  • 39. ESTRATEGIAS DE MEJORA: EL PROFESIONAL. • FORMAR – Patrones de reconocimiento de trastornos/ enfermedades y sus complicaciones. – Script de los trastornos/enfermedades. – Situaciones de alarma. • COMPARTIR – Experiencias clínicas. – Asesoramiento/tutorización directa. • DAR FEEDBACK
  • 40. Propósito Asunción Insuficiencias Enfoque FORMACION Metacognición Hábitos Conductas Caro Individuo mas complejas Experteza Conocimientos Reconocer Caro Individuo COMPARTIR En línea Validar Amplia opciones No inmediato Individuo Sugerir otros Diagn. Segunda opinión Idem Compartir criterios Solo casos Equipo “especiales” Sistema experto Sugerir Exhaustividad Solo casos Individuo “especiales” Participación paciente FEEDBACK Autopsias Mejorar experiencia clínica Relacionar síntomas y Caro, solo casos Equipo signos con diag no “especiales”, obvios resistencia familiares Audit Mejorar procedimientos Disciplina trabajo Nexo no bien Individuo / conlleva mejores establecido Equipo resultados Seguimiento Rectificar Ganar en flexibilidad; Exige planificar. Individuo / Evitar error o Equipo disminuir efectos.
  • 41. ESTRATEGIAS DE MEJORA: EL SISTEMA. • MEJORAR EL RESCATE DE INFORMACION. • MEJORAR LA COMUNICACIÓN ENTRE PROFESIONALES Y EL ACCESO A PRUEBAS. • SISTEMAS EXPERTOS • ALERTAS • TAREAS PENDIENTES • GESTION DE POBLACIONES A RIESGO
  • 42. HISTORIA CLÍNICA ELECTRÓNICA • TAPIZ – LISTA PROBLEMAS – CURSO CLÍNICO • PROBLEMAS/EPISODIOS – PRESCRIPCIONES – HOJA MONITORIZACIÓN, HISTORICO DE PRUEBAS… • INTERCONECTIVIDAD – PRUEBAS COMPLEMENTARIAS – HISTORIA CLINICA ELECTRONICA – CURSOS CLÍNICOS OTROS PROFESIONALES.
  • 43. ALERTAS • ANALITICAS /RADIOLOGIA EN EL MOMENTO DE LA CONEXION • ALTAS HOSPITALARIAS/URGENCIAS • INTERCONSULTAS ESPECIALISTAS • DEFUNCIONES DURANTE EL ACTO • PREASEG CLÍNICO • TAREAS PENDIENTES
  • 44. PERFIL PRESCRIPCION • ON TIME (PREFASEG): – INTERACCIONES. – REDUNDANCIAS (DUPLICADOS) – EDADES EXTREMAS – ENFERMEDADES/CONDICIONES DEL PACIENTE – REACCIONES ADVERSAS /ALERGIAS – TUTOR PEDIATRIA • OFF TIME (SELF AUDIT): – REDUNDANCIAS (DUPLICADOS). – MAS DE 10 FÀRMACOS – NO RECOMENDADOS POR EDAD/ PROTECCIÓN GÀSTRICA, ETC.
  • 45. GESTION DE POBLACIONES A RIESGO • OFF TIME – EPOC. – DIABETICOS – RIESGO CARDIOVASCULAR – OTROS… • EN UN FUTURO – POBLACION DE ESPECIAL SEGUIMIENTO: • DEFINIDO POR VARIOS FACTORES • DEFINIDO POR EL PROFESIONAL – POBLACION DETECTADA POR SISTEMAS EXPERTOS. • VARIABLES BIOLOGICAS • VARIABLES PSICOSOCIALES
  • 46. Prescripción Farmacológica Segura PREFASEG Autores: CAMFiC i ICS Ester Amado Arantxa Catalán Leonardo Galván Jose Miguel Baena Vicente Morales Gladys Bendahan Míriam Oms Francesc Borrell Àngels Pons Con la colaboración de: Fundació Avedis Donabedian Subdirecció General de Recursos Sanitaris Financiación: Aliança per la Seguretat dels Pacients (Departament de Salut, 2007) Ministerio de Sanidad y Política Social (Seguridad de pacientes, 2009)
  • 47. PARA SABER MAS • Aranaz JM, Aibar C, Vitaller J, Mira JJ Gestión Sanitaria. Calidad y Seguridad de los pacientes. Fundación MAPFRE. Diaz de Santos, Madrid 2008. • Baron J. Thinking and Deciding. 3rd ed. Cambridge, UK: • Cambridge University Press; 2003. • Gigerenzer G. Simple Heuristics that Make Us Smart. Oxford, UK: Oxford University Press; 1999. • Kassirer JP, Kopelman RI. Learning Clinical Reasoning. • Baltimore, MD: Williams & Wilkins; 1991. • Godoy A. Toma de decisiones y juicio clínico. Piramide. Madrid 1996. • Dowie JU, Elstein A. Professional judgement. A reader in clinical decision making. Cambridge University Press. New York 1988
  • 48. PARA SABER MAS • Society of Medical Decision Making (available at: http://www.smdm.org • • The Brunswik Society (available at: http://www.brunswik.org ) • Decision Analysis Society (available at: http://faculty.fuqua.duke.edu/daweb ) • Society for Judgment and Decision Making (available at: http://www.sjdm.org) • Center for Adaptive Behavior and Cognition (available at: • http://www.mpib-berlin.mpg.de/en/research/adaptive-behavior-and-cognition • AHRQ Web M&M, October 2007. Available at: http://www.webmm.ahrq.gov/index.aspx
  • 49. MUCHAS GRACIAS POR VUESTRA ATENCION NOS VEMOS EN: www.humedicas.blogspot.com www.seguridadclinica.blogspot.com