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Screening

Dr. Akhilesh Bhargava
      MD, DHA, PGDHRM
   Prof. Community Medicine
               &
    Director-SIHFW, Ja...
Screening
“ application of a medical procedure
                or a test,
                 rapidly,
    to people who as y...
Why screen
Purpose:
       To reduce morbidity/mortality
       by detection at an early stage
    where treatment is more...
Screening criteria

      a disease need to satisfy:

Ø   Life threatening,irreversible,serious

Ø   Treatment at early st...
Qualities of screening test
    üLow cost
    üEasy to administer
                Øskills
                Øtechnique
     ...
Validity

“ ability of a test to do what it is intended to do”

         expressed as sum of-
               Sensitivity+
...
Sensitivity
                           “ A test’s ability to designate an
                           individual with a dis...
Specificity
                       “ability of a test to designate an
                      individual who does not have a...
Changes in specificity/sensitivity…
                   ? Ideal:
     Sensitivity 100%
     Specificity 100% (Increase in o...
Conditions that ask for increase---

     Increase Sensitivity-
              Øserious diseases
              Øa definite ...
Reliability

“ ability to reproduce same results with
                consistency ”
    Factors:
           Biological var...
Evaluation of a screening
     test/program

Disease’s appropriateness         Can a screening
determined                 ...
Feasibility
Ø Acceptability
     • Quick
     • Easy to administer-Less discomfort
Ø Cost-effectiveness
     • Total cost
...
Predictive value of a test

“ a measure to ascertain whether or not a person
tested positive, has the disease ”
          ...
Predictive value - interpretations

    Influencers- Validity-increasing specificity,
                           increases...
PV- interpretations…

Change in -prevalence    PV+ve Sensitivity Specificity
            0.1           1.8    90          ...
Effectiveness

Screening objective- To reduce morbidity/mortality
                     through
                     early ...
Bias in screening

Ø   Self-selection
Ø                                     Time
Ø   Lead time bias (identification-------...
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Screening in Public Health

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Presentation from Dr. Akhilesh Bhargava

Published in: Health & Medicine

Screening in Public Health

  1. 1. Screening Dr. Akhilesh Bhargava MD, DHA, PGDHRM Prof. Community Medicine & Director-SIHFW, Jaipur
  2. 2. Screening “ application of a medical procedure or a test, rapidly, to people who as yet have not developed symptoms of disease for the purpose of determining their likelihood of developing of disease” . Akhilesh Bhargava 2
  3. 3. Why screen Purpose: To reduce morbidity/mortality by detection at an early stage where treatment is more successful, and cost effective Assumption- “Favorable prognosis” as treatment will start before clinical manifestation and arrest the process Akhilesh Bhargava 3
  4. 4. Screening criteria a disease need to satisfy: Ø Life threatening,irreversible,serious Ø Treatment at early stage to be more effective than one given after. Ø High prevalence of detectable pre- clinical stage Akhilesh Bhargava 4
  5. 5. Qualities of screening test üLow cost üEasy to administer Øskills Øtechnique Øminimal discomfort ü Valid ü Reliable ü Reproducible Akhilesh Bhargava 5
  6. 6. Validity “ ability of a test to do what it is intended to do” expressed as sum of- Sensitivity+ Specificity+ Reliability(reproducibility) Yield Akhilesh Bhargava 6
  7. 7. Sensitivity “ A test’s ability to designate an individual with a disease as positive”, expressed as a/(a+c) Highly sensitive • a few false negatives • fewer cases of disease missed Disease Test +ve -ve +ve a b a+b -ve c d c+d a+c b+d Results depend on criteria of positivity Akhilesh Bhargava 7
  8. 8. Specificity “ability of a test to designate an individual who does not have a disease as negative, expressed as d / b+d .” a highly specific test: - a few false positives - a fewer cases without Disease disease are included Test +ve -ve +ve a b a+b -ve c d c+d a+c b+d Akhilesh Bhargava 8
  9. 9. Changes in specificity/sensitivity… ? Ideal: Sensitivity 100% Specificity 100% (Increase in one at cost on other and depend on positivity criterion) Less stringent- sensitivity increases (more of actually diseased test +ve, no. without disease also increase) More strict - specificity increases (large no. test –ve, more no. of true cases will be missed) Akhilesh Bhargava 9
  10. 10. Conditions that ask for increase--- Increase Sensitivity- Øserious diseases Øa definite treatment exists Øsubsequent diagnostic tests cost less Increase Specificity- Øsubsequent diagnosis costly, risky Akhilesh Bhargava 10
  11. 11. Reliability “ ability to reproduce same results with consistency ” Factors: Biological variations Variation in method of testing Intra-observer variation Inter- observer variation Akhilesh Bhargava 11
  12. 12. Evaluation of a screening test/program Disease’s appropriateness Can a screening determined test Valid test available be introduced ? Feasibility ? Effectiveness ? Akhilesh Bhargava 12
  13. 13. Feasibility Ø Acceptability • Quick • Easy to administer-Less discomfort Ø Cost-effectiveness • Total cost • Unit cost • Follow-up cost Ø Subsequent diagnosis & treatment of +ve Ø Yield (no. detected) Measure- Predictive value Akhilesh Bhargava 13
  14. 14. Predictive value of a test “ a measure to ascertain whether or not a person tested positive, has the disease ” Disease Test Present Absent +ve 900(a) 4950(b) PV+ve (TP) ( FP) (TP/TP+FP)=91% -ve 100(c) 94050(d) PV-ve ( FN ) (TN ) (TN/FN+TN)=99.9% Total 1000 99000 Sensitivity-TP/TP+F= Specificity-TN/FP+TN= Akhilesh Bhargava 14
  15. 15. Predictive value - interpretations Influencers- Validity-increasing specificity, increases PV+ve test Prevalence of pre-clinical disease 900 4950 5850 900 1980 2880 100 94050 94150 100 97020 97120 sens.-a/a+c=90% 90% speci.-d/b+d=95% 98% PV+ve-a/a+b=15.4% 31.3% PV-ve- d/c+d=99.9% 99.9%
  16. 16. PV- interpretations… Change in -prevalence PV+ve Sensitivity Specificity 0.1 1.8 90 95 1.0 15.4 90 95 5.0 48.6 90 95 50.0 94.7 90 95 PV+ve can be increased by -increasing specificity -increasing prevalence
  17. 17. Effectiveness Screening objective- To reduce morbidity/mortality through early detection & offering treatment in pre-clinical stage To be effective- -groups need to be comparable -scrutinized for ascertainment of outcome -bias reduced
  18. 18. Bias in screening Ø Self-selection Ø Time Ø Lead time bias (identification----------------diagnosis during screening after symptoms Ø Length bias- over representation of those with long pre-clinical phase, amongst screened (heterogeneous nature of disease, prevalence dependent on duration)

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