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Introduction  Hypersensitivity is increased reactivity or increased sensitivity by the animal body to an antigen to which it has been previously exposed.  The term is often used as a synonym for allergy, which describes a state of altered reactivity to an antigen.  Hypersensitivity has been divided into categories based upon whether it can be passively transferred by antibodies or by specifically immune lymphoid cells.  The most widely adopted current classification is that of Coombs and Gell that designates immunoglobulin-mediated (immediate) hypersensitivity reactions as types I, II, and III, and lymphoid cell-mediated (delayed-type) hypersensitivity/cell-mediated immunity as a type IV reaction.  “Hypersensitivity” generally represents the “dark side,” signifying the undesirable aspects of an immune reaction, whereas the term “immunity” implies a desirable effect.  A hypersensitive response (HR) is an anti-pathogen response in plants produced by avr-R system activation that leads to alterations in Ca+ flux, MAPK activation, and NO and ROI formation.  There is rapid necrosis of plant cells in contact with the pathogen.  This process prevents spread of the pathogen and releases hydrolytic enzymes that facilitate injury to the pathogen’s structural integrity. Causes of Hypersensitivity Immune responses that are the cause of hypersensitivity diseases may be specific for antigens from different sources:  Autoimmunity: reactions against self antigens.  Reactions against microbes.  Reactions against non-microbial environmental antigens. Mechanism of Hypersensitivity Hypersensitivity diseases are commonly classified according to the type of immune response and the effector mechanism responsible for cell and tissue injury. These mechanisms include some that are predominantly dependent on antibodies and others predominantly dependent on T cells, although a role for both humoral and cell-mediated immunity is often found in many hypersensitivity diseases.Hypersensitivity 1

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A condition in which the immune system reacts abnormally to a foreign substance. Drug allergy An abnormal reaction of the immune system to a medication. Food allergies An unpleasant or dangerous immune system reaction after a certain food is eaten. Contact dermatitis A skin rash caused by contact with a certain substance. Latex allergy An allergic reaction to certain proteins found in natural rubber latex. Allergic asthma Asthma triggered by exposure to the same substances that trigger allergy symptoms. Seasonal allergies An allergic response causing itchy, watery eyes, sneezing and other similar symptoms. Animal allergy An abnormal immune reaction to proteins in an animal's skin cells, saliva or urine. Anaphylaxis A severe, potentially life-threatening allergic reaction. Allergy to mold An abnormal allergic reaction to mould spores.Hypersensitivity (Allergy) - Drug allergy, Contact dermatitis, Allergic asthma

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