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Allergic reaction includes the degranulation process, shown here

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  1. 1. Allergy Degranulation Process
  2. 2. Allergy <ul><li>Activated mast cells go through a process called degranulation. They release histamine and other chemicals causing inflammation. </li></ul>
  3. 3. Allergy <ul><li>The antigen floats around the body … </li></ul>
  4. 4. Allergy <ul><li>IgE antibod ies find allergen and attach themselves to it. </li></ul>
  5. 5. Allergy <ul><li>IgE binds to IgE receptors on surface of mast cells (a type of immune cell) </li></ul><ul><li>This is a kind of FC receptor. </li></ul>
  6. 6. Allergy <ul><li>Stored mediators (4) such as histamine, proteases, chemokines and heparine are released from granules (5) </li></ul>
  7. 7. Allergy <ul><li>N ewly formed mediators also released (prostaglandins, leukotrienes, thromboxanes amd PAF) </li></ul>
  8. 8. Allergy <ul><li>Produced by </li></ul><ul><li>Material from Wikipedia </li></ul><ul><li>Image by Paweł Kuźniar </li></ul>