This document provides information about Desoxyn, which is the brand name for crystal methamphetamine. It discusses the history of methamphetamine beginning with its use in traditional Chinese medicine thousands of years ago. Desoxyn was approved for medical use in the 1930s and is still prescribed today for conditions like ADHD and obesity, though it carries high addiction risks. The document outlines appropriate and inappropriate users of Desoxyn, recommended dosages, potential side effects, drug interactions to avoid, and overdose treatment. While Desoxyn is a regulated pharmaceutical, it has the same addictive properties and health risks as illegal street methamphetamine.

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Table of Contents
What’s The History Of Desoxyn (Methamphetamine)?.......................................... 3
Desoxyn (Methamphetamine Hydrochloride)........................................................ 5
Who Should Take Desoxyn?................................................................................... 5
Who Should Not Take Desoxyn?. ........................................................................... 6
What Is The Required Dosage For Desoxyn?.......................................................... 7
What Are The Side Effects Of Desoxyn?................................................................. 7
What Should I Do If I Overdose On Desoxyn? ........................................................ 8
What Should I Do If I Miss My Desoxyn Dose? ....................................................... 8
What Food And Medication Should I Avoid When Taking Desoxyn? ...................... 9
Is Desoxyn Safer Than Street Meth? ...................................................................... 9

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What’s The History Of Desoxyn
(Methamphetamine)?
Let’s begin with a brief history of Desoxyn a long time before it became modern medication in
pharmacies in the United States. The life of Desoxyn began with a plant that has been used in
traditional Chinese medicine for thousands of years.
The name of the plant is Ephedra and its extract has been used in traditional Chinese medicine
since 3,000 BC i.e over 5,000 years ago. It’s known that when Ephedra plant is ingested, it
creates euphoria and decreases food intake. It just makes people feel good.
In 1885, Nagai Nagayoshi- a Japanese chemist studying in Germany, identified the active
chemical (stimulant) in the Ephedra plant. The stimulant in the plant was called ephedrine-
courtesy of the originator plant Ephedra. After more research into the constituents of
ephedrine, scientists were able to develop amphetamine-type stimulants (including
methamphetamine) as a synthetic or man-made alternative to the ephedra plant extract. But
they remained in powder form.

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At that time, methamphetamine
was difficult to make.
Fortunately, in 1919, another
Japanese chemist, Akira Ogata
streamlined the process by using
phosphorus and iodine to reduce
the ephedrine into a crystallized
form, thereby, creating the world’s
first crystal meth.
Methamphetamine was then
immediately used as a medical
treatment for narcolepsy, asthma
and as a weight-loss drug. You
didn’t need a doctor or prescription
to get it.
In 1932, American pharmaceutical
company Smith, Kline, and French
began marketing an amphetamine
inhaler for use in asthma and nasal
congestion. The inhaler medication, called Benzedrine, was as I said initially available without a
prescription. People soon discovered its euphoric, energizing side effects. And because of these
stimulant-type effects, pharmaceutical companies began to manufacture Benzedrine in pill
form for narcolepsy (a sleep disorder).
In 1942, a U.S pharmaceutical company by name Abbot Laboratories produced the first
commercial methamphetamine.
In 1942, during the Second World War, the allied forces and Axis powers both used the drug to
keep troops awake. After the war, meth use increased dramatically out of control.
In 1970, the United States outlawed methamphetamine but the drug use escalated the more
and eventually went underground.
In about 1975, in the USA, Desoxyn started being produced as ‘’legal’’ crystal
methamphetamine.
That's about the history and timeline.

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Desoxyn (Methamphetamine Hydrochloride)
Desoxyn belongs to the amphetamine drug
family, along with Adderall and many others.
Amphetamines are also known as central nervous
system (CNS) stimulants. The most powerful of
the amphetamine drug family ever manufactured
is Methamphetamine.
In the United States, Desoxyn is a schedule II drug,
which means it has a high potential for abuse and
dependence. Other schedule II drugs include
Vicodin, OxyContin, fentanyl, cocaine, Adderall,
and Ritalin. Desoxyn is manufactured and
distributed in the U.S. by Ovation
Pharmaceuticals, an American company now
owned by a Dutch pharmaceutical company,
Lundbeck.
Many people don't know that this legal version of
methamphetamine exists and that it could be
prescribed by a doctor. When Desoxyn
prescribed, the user gets the same formula every
time, which can’t be said for methamphetamine
purchased on the street. However, whether
regulated or not, whether purchased on the
street or not, it’s still the same old
methamphetamine used in the Second World
War. There's no difference on the effect on the user.
Who Should Take Desoxyn?
Desoxyn is generally prescribed for the following conditions:
 Attention deficit hyperactivity disorder (ADHD): Often prescribed for people who struggle
with severe distractibility, hyperactivity, impulsivity, short attention span and emotional
liability.
 Obesity: Prescribed for patients who aren’t losing weight and body fat by dieting, group
programs or use of other drugs.
 Narcolepsy: Prescribed for people having frequent sleep and unable to stay awake.
 Depression: It has also been prescribed to patients suffering depression or its tendencies.

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Who Should Not Take Desoxyn?
Only people battling severe ADHD, obesity, narcolepsy, and possibly depression should take
Desoxyn. Even then, one should not take Desoxyn if one or more of the following conditions
occur:
 An allergy to methamphetamine
 Heart disease
 Moderate to severe high blood pressure
(hypertension)
 Overactive thyroid
 Severe anxiety, tension or agitation
 Glaucoma
 History of drug or alcohol abuse
 Parkinson’s or depression and you take
monoamine oxidase (MAO) inhibitors
(such as Marplan, Azilect, Parnate, etc.)
 Pregnant and nursing mothers
 And if one of the following conditions is
present, one should be careful when
taking Desoxyn, possibly adjusting the
dose of the existing medication:
 Diabetes
 Mild hypertension
 Congenital heart defect
 Heart rhythm disorder
 Recent heart attack
 Muscle twitches (tics) or Tourette’s
syndrome
 Previous suicide attempt(s)
 Family history of mental illness (such as
psychotic disorder, depression or
bipolar disorder)
Be sure to discuss these conditions with your doctor before he or she considers prescribing
Desoxyn to you. Your doctor can help you with adjusting the dose of your other medications, if
needed.

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What Is The Required Dosage For Desoxyn?
Desoxyn is meant to be a short-term regimen when prescribed to treat obesity. Patients on this
regimen should take one 5-milligram tablet roughly a half-hour before each meal. The regimen
should not last longer than a few weeks.
For patients with ADHD, the initial dose should be 5 milligrams once or twice a day. The daily
dosage can increase in 5 milligram increments each week until topping out at either 20 to 25
milligrams daily. The doctor may suggest cutting off the dose periodically to see if the previous
behavior symptoms return. If they don’t, or if they return at a lesser degree, then the doctor
may recommend lowering the daily dose or weaning the patient off the drug altogether.
Patients taking this drug need to see their doctor on a regular basis and not miss any scheduled
visits. The drug needs to be taken with a full glass of water, and patients are strongly advised
not to take an extra dose or misuse the drug, which increases the risk of severe side effects and
even death.
What Are The Side Effects Of Desoxyn?
The potential side effects of Desoxyn could be divided into mild and severe. The milder, but still
discomforting, potential side effects include:
 Diarrhea
 Constipation
 Dry mouth or bad taste in mouth
 Headache or dizziness
 Insomnia
 Loss of appetite
 Weight loss in ADHD patients
 Slowing of growth in children
 Impotence or loss of interest in sex
 The severe side effects include the
following…………:
 Fast or uneven heartbeats
 Lightheadedness or fainting
 Tremors
 Hallucinations
 Motor tics (muscle twitches)
 Out-of-character behavior
 Severe anxiety
 Severe headache
 Blurred vision
 Buzzing in ears
 Chest pain
 Shortness of breath
 SeizureFast or uneven heartbeats
 Lightheadedness or fainting
 Tremors
 Hallucinations
 Motor tics (muscle twitches)
 Out-of-character behavior
 Severe anxiety
 Severe headache
 Blurred vision
 Buzzing in ears
 Chest pain
 Shortness of breath
 Seizure
If you suffer any of the above severe side effects, you should stop using the drug and call your
doctor immediately.

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What Should I Do If I Overdose On Desoxyn?
If you or someone you know has overdosed on Desoxyn, you'll notice one or many of the
symptoms among the “severe side effects” listed above. Seek emergency medical attention at a
hospital or urgent care facility if this has happened. Desoxyn overdose can result in coma or
death.
What Should I Do If I Miss My Desoxyn Dose?
Doctors usually recommend taking Desoxyn twice a day, at most. If you miss a dose, try to take
it as soon as possible. However, be careful of taking it late in the day, as this could make it hard
to fall asleep at night. In this scenario, just wait until the next morning to take a dose again.
Also, DO NOT take the dose if it’s almost time for the next dose, and do not take an extra dose
to make up for a missed dose. If you miss it, you miss it.

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What Food And
Medication Should
I Avoid When
Taking Desoxyn?
If you’re on an active Desoxyn regimen,
you should avoid drinking fruit juices or
taking vitamin C around the same time
because they inhibit the body’s ability
to fully absorb the medicine.
Desoxyn has also shown a negative
interaction with the following types of
drugs:
 Cold medication (decongestants)
 Insulin for diabetes
 MAO inhibitors (as mentioned
earlier)
 Phenothiazines (such as Compro,
Compazine, Thorazine, etc.), which
treat schizophrenia and other
psychotic disorders, in addition to
severe nausea, vomiting and
hiccups.
Is Desoxyn Safer
Than Street Meth?
Desoxyn is the same as
methamphetamine and carries the
same side effects and dangers as crystal
meth. Both are highly addictive.
However, you can at least count on
Desoxyn as being a legal form of meth,
produced in a safe and regulated
environment by professionals.
Dr. Martin Russell, MD