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Disease related to leukocytes (wb cs)
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Disease related to leukocytes (wb cs)

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  • 1. DISEASE RELATED TOLEUKOCYTES (WBCs)
  • 2. LEUKOPENIA & LEUKEMIAS
  • 3. LEUKOPENIA Bone marrow produces very few WBCs This leaves the body unprotected against many bacteria and others agents might invade the tissues
  • 4. Causes of Leukopenia Irridation by x-rays or gamma rays Exposure to drugs and chemicals that contain benzene
  • 5. Effects of Leukopenia on theBody Decrease in the number of WBCs immediately allows invasion of adjacent tissues by bacteria that are already present Within 2 days after the bone marrow stops producing WBCs, ulcers may appears in the mouth and colon, or develop some form of severe respiratory infection Bacteria from the ulcers rapidly invade surrounding the tissues and the blood Without treatment, death often ensues in less than a week after acute total leukopenia begins
  • 6. LEUKEMIAS Uncontrolled production of WBCs Caused by cancerous mutation of a myelogenous or lymphogenous cell Usually characterized by greatly increased numbers of abnormal WBCs in the circulating blood
  • 7. TYPES OF LEUKEMIA Lymphocytic leukemias Myelogenous leukemias
  • 8. Lymphocytic Leukemias Caused by cancerous production of lymphoid cells Usually beginning in a lymph node or other lymphocytic tissue and spreading to other areas of the body
  • 9. Myelogenous luekemias Begins by cancerous production of myelogenous cells in bone marrow Then, spreads throughout the body so that white blood cells are produced in many extramedullary tissues… -especially in the lymph nodes, spleen and liver
  • 10. Effects of Leukemias on theBody Metastatic growth of leukemic cells in abnormal areas of the body Leukemic cells from the bone marrow may reproduce so greatly that they invade the surrounding bone, causing pain and eventually, a tendency for bones to fractures easily Leukemias spread to the spleen, lymph nodes, liver, and other vascular regions regardless of whether the origin of the leukemia is in the bone marrow or the lymph nodes
  • 11. Effects of Leukemias on theBody Commonly it will increase the development of infection, severe anemia, and a bleeding tendency caused by thrombocytopenia(lack of platelets) Excessive use of metabolic substrates by the growing cancerous cells The leukemic tissues reproduce new cells so rapidly that tremendous demands are made on the body reserves for foodstuffs, specific amino acids, and vitamins
  • 12. Effects of Leukemias on theBody Consequently, the energy of the patient is greatly depleted, and excessive utilization of amino acids by the leukemic cells causes especially rapid deterioration of the normal protein tissues of the body Thus, while the leukemic tissues grow, other tissues grow, other tissues becomes debilitated After metabolic starvation has continued long enough, this alone is sufficient to cause death
  • 13. THEEND