If if we r seeing premature neutrophils –AML , premature lymphocytes-ALL
12 - 17 µm ..3 times the size of RBC..Lobes from 2 to 4.. If no lobes den band form of neutrophils.
necrosis- premature death of cells in living tissue by autolysis…Coagulative-heart , liquefactive –brain… caseous-TB Acute blood loss-internal or external ..internal due an ulcer bleeding …external – trauma Metabolic disorders- gauchers(glucocerobridase) , glycogen storage disorder Poisoning –CO …
Relative lymphocytosis is followed by neutropenia during recovery phase Miliary TB- extra pulmonary involvement of TB…rubella –also called german measles , Influenza –H1N1 haemagglutinin and neuraminidase
NEN-whr maternal antibodies cross the placenta and destroy fetal neutrophils.baby , the neonate wil start presenting with severe bacterial infections. SLE- multi system auto immune disorder due to production of antinuclear antibodies. Butterfly rashes Felty syndrome, is characterized by the combination of rheumatoid arthritis, splenomegaly andneutropenia.
12 - 17 µm The eosinophil generally has a nucleus with two lobes (bilobed), and cytoplasm filled with approximately 200 large granules within the cellular cytoplasm, which contain many chemical mediators, such as histamines and major basic protein
Eczema-skin rashes and itchng,,, Dermatitis herpetiformis (DH) chronic blistering skin condition, characterised by blisters . Despite its name, DH is neither related to nor caused by herpes virus… Parasite- malaria , round worms of intestine Loeffler's syndrome is a disease in which eosinophils accumulate in the lung in response to a parasiticinfection in intestine. Filariasis most prevelant in Bihar and UP and in south india kerala has got the highest number f cases
14-16 µm…basophils, are the least common of the granulocytes, representing 0.1% of circulating white blood cells containing deep blue staining large dense granules which cover the nucleus…n granules contain serotoin , heparine and histamine. help to increase blood flow to the area of damage, as part of the inflammatory response.
Vera- bone marrow makes too many red blood cells. It may also result in the overproduction of white blood cells and platelets. Myxedema- both hypo an hper … but usually hypo…
Largest f all leucocytes…size is around 18 micro meter…third most common type of white blood cell.. Monocytes in the circulation are precursors of tissue macrophages … Monocytes have bean-shaped nuclei that are unilobar…Clear cytoplasm … Kuffer cell –liver Langerhans cell-skin Microglia-CNS Mesengial cell-kidney Osteoclast-Bone Histiocytes-LN
Chronic ifections lik TB ,,, Endocarditis- streptococci… clubbing- lung cancer , abscess in lung, cirrhosis f liver , malabsorption…
Small around 7 microm and large aroubd 14 microm… Lymphocytes can look like monocytes, except that lymphocytes do not have a kidney-bean shaped shaped nucleus, and lymphocytes are usually smaller.most f dem r small and only 10 % is large lymphocyte…Large l wil ve more cytoplasm n may contain granule in it.
Brucellosis – by drinking milk which is not pasteurized
▪ Definition of DLC
▪ Identification of WBCs
▪ Conditions effectingWBCs count
DLC-Relative proportion of different
leukocytes expressed as percentage.
▪ To support the diagnosis of infectious , inflammatory or
▪ Diagnosis of malignant blood disorders