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Differential Leukocyte
Count
Dr.Raghuveer.CR
Objectives
▪ Definition of DLC
▪ Identification of WBCs
▪ Functions
▪ Conditions effectingWBCs count
DLC-Relative proportion of different
leukocytes expressed as percentage.
USES:
▪ To support the diagnosis of infectious , ...
Identification-Neutrophils
Neutrophilia-ANC7500/microL
▪ Acute bacterial infections
▪ Tissue necrosis
▪ Acute blood loss
▪ Acute haemorrhage
▪ Metabo...
Neutropenia-ANC<2000/microL
▪ Decreased or ineffective production in BM
▪ Infections-Typhoid , MiliaryTuberculosis, measle...
Increased destruction
▪ Neonatal isoimmune neutropenia
▪ Systemic lupus erythematous
▪ Felty’s syndrome
Eosinophil
Eosinophilia-AEC>600/microL
▪ Allergic diseases
▪ Skin diseases- Eczema , dermatitis herpetiformis
▪ Parasitic infection
▪...
Basophil
Basophilia- ABC >100/ microL
▪ CML
▪ Polycythemia vera
▪ Myxedema
▪ Drug/food allergies
Monocyte
Monocytosis AMC>1000/micro l
▪ Infections-TB , Sub Acute Bacterial Endocarditis
▪ Hodgkins disease
▪ Ulcerative colitis , ...
Small and Large lymphocyte
Lymphocytosis
▪ ALC >4000(adults) >9000(children)
Infections- Hepatitis , Cyto megalo virus , mumps , rubella ,
varicella ...
???
Summary
▪ DLC-Relative proportion of leucocytes
▪ Neutrophils-40 -60%- Acute infection
▪ Lymphocytes-20 – 40%-Viral infect...
Thank You
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Differential leukocyte

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Differential leukocyte

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Differential leukocyte

  1. 1. Differential Leukocyte Count Dr.Raghuveer.CR
  2. 2. Objectives ▪ Definition of DLC ▪ Identification of WBCs ▪ Functions ▪ Conditions effectingWBCs count
  3. 3. DLC-Relative proportion of different leukocytes expressed as percentage. USES: ▪ To support the diagnosis of infectious , inflammatory or allergic disorders. ▪ Diagnosis of malignant blood disorders
  4. 4. Identification-Neutrophils
  5. 5. Neutrophilia-ANC7500/microL ▪ Acute bacterial infections ▪ Tissue necrosis ▪ Acute blood loss ▪ Acute haemorrhage ▪ Metabolic disorders ▪ Poisoning ▪ Malignant tumors
  6. 6. Neutropenia-ANC<2000/microL ▪ Decreased or ineffective production in BM ▪ Infections-Typhoid , MiliaryTuberculosis, measles , rubella , influenza ▪ Hematologic disorders ▪ Drugs-Analgesics , antithyroid drugs , anti cancer drugs ▪ Ionizing radiation
  7. 7. Increased destruction ▪ Neonatal isoimmune neutropenia ▪ Systemic lupus erythematous ▪ Felty’s syndrome
  8. 8. Eosinophil
  9. 9. Eosinophilia-AEC>600/microL ▪ Allergic diseases ▪ Skin diseases- Eczema , dermatitis herpetiformis ▪ Parasitic infection ▪ Carcinoma with necrosis ▪ Lung diseases- Loffler's syndrome , tropical eosinophilia
  10. 10. Basophil
  11. 11. Basophilia- ABC >100/ microL ▪ CML ▪ Polycythemia vera ▪ Myxedema ▪ Drug/food allergies
  12. 12. Monocyte
  13. 13. Monocytosis AMC>1000/micro l ▪ Infections-TB , Sub Acute Bacterial Endocarditis ▪ Hodgkins disease ▪ Ulcerative colitis , Chrons disease
  14. 14. Small and Large lymphocyte
  15. 15. Lymphocytosis ▪ ALC >4000(adults) >9000(children) Infections- Hepatitis , Cyto megalo virus , mumps , rubella , varicella ,TB , Brucellosis AML , CML , Multiple myeloma
  16. 16. ???
  17. 17. Summary ▪ DLC-Relative proportion of leucocytes ▪ Neutrophils-40 -60%- Acute infection ▪ Lymphocytes-20 – 40%-Viral infection ▪ Monocytes: 2 – 8%-Chronic inflammation ▪ Eosinophils: 1 – 4%-Allergy and parasitic infection ▪ Basophils: 0.5 – 1%--CML
  18. 18. Thank You

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