Here is data from a CBC in a person with iron deficiency anemia. Note the lowhemoglobin (HGB). Microcytosis is indicated by the low MCV (mean corpuscularvolume). Hypochromia correlates here with the low MCH (mean corpuscularhemoglobin).
The CBC here shows a markedly increased MCV, typical for megaloblastic anemia. TheMCV can be mildly increased in persons recovering from blood loss or hemolyticanemia, because the newly released RBCs, the reticulocytes, are increased in size overnormal RBCs, which decrease in size slightly with aging.
This CBC demonstrates findings suggestive of spherocytosis, a condition in which theRBCs are small and round (rather than the normal biconcave appearance) withincreased hemoglobin content. This is indicated here by the increase MCHC (meancorpuscular hemoglobin concentration). There is a rare condition known as hereditaryspherocytosis. Also, RBCs in the condition of autoimmune hemolytic anemia can alsoappear similarly.
Symptoms of Anemia • Fatigue • Shortness of breath • Dizziness • Pale or yellowish skin • Swollen tongue that may appear dark red • Weight loss • Diarrhea • Numbness or tingling in your hands and feet • Muscle weakness • Irritability • Unsteady movements • Mental confusion or forgetfulness
Anemia Definition:Decrease in hemoglobin concentrationbelow the normal value for the age, sex and for the given individual
Classification of anemiasThere are many classifications of anemia• Based on underlying mechanisms• Morphologic characteristics
Anemias due to BLOOD LOSS Mechanism Specific Examples BLOOD LOSS Acute blood loss Trauma Chronic blood loss Gastrointestinal tract lesions, gynecologic disturbances