Disease related to leukocytes (wb cs)

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Disease related to leukocytes (wb cs)

  1. 1. DISEASE RELATED TOLEUKOCYTES (WBCs)
  2. 2. LEUKOPENIA & LEUKEMIAS
  3. 3. LEUKOPENIA Bone marrow produces very few WBCs This leaves the body unprotected against many bacteria and others agents might invade the tissues
  4. 4. Causes of Leukopenia Irridation by x-rays or gamma rays Exposure to drugs and chemicals that contain benzene
  5. 5. Effects of Leukopenia on theBody Decrease in the number of WBCs immediately allows invasion of adjacent tissues by bacteria that are already present Within 2 days after the bone marrow stops producing WBCs, ulcers may appears in the mouth and colon, or develop some form of severe respiratory infection Bacteria from the ulcers rapidly invade surrounding the tissues and the blood Without treatment, death often ensues in less than a week after acute total leukopenia begins
  6. 6. LEUKEMIAS Uncontrolled production of WBCs Caused by cancerous mutation of a myelogenous or lymphogenous cell Usually characterized by greatly increased numbers of abnormal WBCs in the circulating blood
  7. 7. TYPES OF LEUKEMIA Lymphocytic leukemias Myelogenous leukemias
  8. 8. Lymphocytic Leukemias Caused by cancerous production of lymphoid cells Usually beginning in a lymph node or other lymphocytic tissue and spreading to other areas of the body
  9. 9. Myelogenous luekemias Begins by cancerous production of myelogenous cells in bone marrow Then, spreads throughout the body so that white blood cells are produced in many extramedullary tissues… -especially in the lymph nodes, spleen and liver
  10. 10. Effects of Leukemias on theBody Metastatic growth of leukemic cells in abnormal areas of the body Leukemic cells from the bone marrow may reproduce so greatly that they invade the surrounding bone, causing pain and eventually, a tendency for bones to fractures easily Leukemias spread to the spleen, lymph nodes, liver, and other vascular regions regardless of whether the origin of the leukemia is in the bone marrow or the lymph nodes
  11. 11. Effects of Leukemias on theBody Commonly it will increase the development of infection, severe anemia, and a bleeding tendency caused by thrombocytopenia(lack of platelets) Excessive use of metabolic substrates by the growing cancerous cells The leukemic tissues reproduce new cells so rapidly that tremendous demands are made on the body reserves for foodstuffs, specific amino acids, and vitamins
  12. 12. Effects of Leukemias on theBody Consequently, the energy of the patient is greatly depleted, and excessive utilization of amino acids by the leukemic cells causes especially rapid deterioration of the normal protein tissues of the body Thus, while the leukemic tissues grow, other tissues grow, other tissues becomes debilitated After metabolic starvation has continued long enough, this alone is sufficient to cause death
  13. 13. THEEND

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