Pharmaceutical07
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Slides from a 2007 presentation by Dr Liz Young of AstraZeneca Pharmaceuticals as part of the Careers After Biological Sciences seminar series. (c) Elizabeth Young, 2007
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Pharmaceutical07
- 1. Life in the pharmaceutical industry Elizabeth Young Lead Generation Biology AstraZeneca R&D Charnwood E A Young AstraZeneca R&D Charnwood
- 2. Presentation Overview My background Motivation AstraZeneca Drug Discovery Process A Life in the Day Industry & Academia Advantages & Disadvantages A career @ AstraZeneca What is required? E A Young AstraZeneca R&D Charnwood
- 3. My background BSc Biological Sci (Hons) 1986-1989 Leicester University Merck Sharp & Dohme 1989-1991 Terlings Park PhD Insulin signalling 1991-1994 Bristol University Parke-Davis 1994-2000 Cambridge UK AstraZeneca 2000- Loughborough E A Young AstraZeneca R&D Charnwood
- 4. Sabbatical E A Young AstraZeneca R&D Charnwood
- 5. Why industry? Application of biological sciences to development of product to meet medical need E A Young AstraZeneca R&D Charnwood
- 6. AstraZeneca International http://www.astrazeneca.com E A Young AstraZeneca R&D Charnwood
- 7. AstraZeneca International http://www.astrazeneca.com E A Young AstraZeneca R&D Charnwood
- 8. Facts & Figures More than 65,000 employees worldwide* 18% in the UK, 21% in Sweden, 21% in the US, 40% rest of the world $15 million every working day on new medicines R&D* 14-18% sales re-invested in R&D $1 billion idea → market *Source http://www.astrazeneca.com E A Young AstraZeneca R&D Charnwood
- 9. Drugs cost money… 1 in 10 drugs in Phase I clinical trials get to market 33% marketed drugs do not breakeven Breakeven takes 5-7 yrs from launch 1 in 10 marketed drugs is a Blockbuster More than $1 billion of revenue pa – Lipitor $12b pa Marketing & sales in 1st yr launch = total R&D spend on drug 4 HTS → 1 Lead Optimisation Project 1 HTS >0.5 million compounds Early failure desirable Cost rises as project advances E A Young AstraZeneca R&D Charnwood
- 10. AstraZeneca: People, Culture & Values People are “most valued resource” Development Help employees deliver their best & achieve potential Tailored plans for the individual Management supports learning & development Reward Not only remuneration Flexibility is an important feature Introduction of choice Values Commitment to Competitiveness & Performance – Should not compromise Values – Integrity, high ethical standards – Respect individual & environment – Openness, honesty, trust & support each other E A Young AstraZeneca R&D Charnwood – Leadership by example @ all levels
- 11. AstraZeneca: People, Culture & Values Communication Open & varied lines of communication – Business developments – Roles & targets aligned to Business Feedback – 2-yearly global employee survey Leadership Global programmes – Leadership capabilities – Management skills Wellbeing Global Health, Safety & Welfare initiatives – Work/Life balance promoted – Flexible working – Charnwood WellBeing Centre E A Young AstraZeneca R&D Charnwood
- 12. AZ Charnwood on-site gym E A Young AstraZeneca R&D Charnwood
- 13. AstraZeneca R&D Charnwood E A Young AstraZeneca R&D Charnwood
- 14. AstraZeneca R&D Charnwood Situated on the edge of Loughborough NW Leicestershire 28 ha site bordering open meadowland R&D site – Respiratory & Inflammatory Research Areas Loughborough’s 2nd largest employer – 1,200 staff – High local profile – Community projects – “Groundforce” Day @ local children’s special school E A Young AstraZeneca R&D Charnwood
- 15. Groundforce Day @ Children’s Home E A Young AstraZeneca R&D Charnwood
- 16. Drug Discovery Process Target Identification Hit Lead Clinical Dev & Trials Market Pre-CD Lead Optimisation & Validation Identification Identification E A Young AstraZeneca R&D Charnwood
- 17. Lead Generation Process 1 2 2.5 3 4 5 TG DISCOVERY DEVELOPMENT Target Hit Lead Lead CD Principle Concept Dev. For Launch Product Id. Id. Id. Opt. Pre. Test. Test. Launch Phase LCM 1 MS 2 3 4 5 6 7 8 9 Lead Generation E A Young AstraZeneca R&D Charnwood
- 18. Lead Generation Terms Active Compound showing activity in a specific target screen Often the output of an HTS – X % efficacy @ 10 μM Hit (the basis of an Lead Identification project) Compound with confirmed structure & purity having clear concentration-response activity in follow up screens IC50 10 μM (pIC50 5.0) in a cell-based assay Lead (the basis of an Lead Optimisation project) Compound amenable to chemical modifications resulting in improved activity & selectivity One of a set of related compounds displaying a Structure-Activity Relationship (SAR) – IC50 0.1 μM (pIC50 7.0) in a cell-based assay – Suitable for oral dosing as an investigative tool E A Young AstraZeneca R&D Charnwood
- 19. A life in the day… Office Laboratory Data analysis Compounds arrive Write-up & upload Assemble assay Discussion with colleagues – E.g. cells + compounds Select compounds for progression Capture data Literature searching Assay development New project ideas Meetings – Team, project, dept, safety etc E A Young AstraZeneca R&D Charnwood
- 20. Industry v Academia Advantages Disadvantages E A Young AstraZeneca R&D Charnwood
- 21. Advantages Applied Research New projects End product Compensation Working towards improving Choice people’s QoL – Cash + pension, retail & Facilities childcare vouchers, bikes, holiday…… Equipment Flexible working Global Compound, Reagents & Data collections Performance bonus – Cash Multidisciplinary environment – Shares Commercial environment Career opportunities Budgets women (& men) with families Diverse opportunities (e.g.lab & No grant applications non-lab based) E A Young AstraZeneca R&D Charnwood
- 22. E A Young AstraZeneca R&D Charnwood
- 23. Disadvantages Commercial environment Mergers & Acquisitions Budgets Changing projects E A Young AstraZeneca R&D Charnwood
- 24. A career @ AstraZeneca What is required? 1st or 2.1 degree &/or PhD – appropriate subject Practical experience – Sandwich year – Work experience Hugely competitive 3 posts, >100 applicants http://www.astrazeneca.com E A Young AstraZeneca R&D Charnwood
- 25. The 100th Charnwood HTS: rewarding effort E A Young AstraZeneca R&D Charnwood
- 26. Acknowledgements Industrial (AZ) Adrian Freeman David Keeling John Unitt Academia Gary Willars, University of Leicester Ken Young, MRC Toxicology, Leicester E A Young AstraZeneca R&D Charnwood