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Gastroenterology
Sections
 General Pathophysiology,
  Assessment, and Treatment
 Specific Illnesses
General Pathophysiology
 General Risk Factors
      Excessive Alcohol Consumption
      Excessive Smoking
      Increased Stress
      Ingestion of Caustic Substances
      Poor Bowel Habits
 Emergencies
    Acute emergencies usually arise from chronic
     underlying problems.
Abdominal
  Pain
 Types
   Visceral
   Somatic
   Referred

 Causes
   Inflammation
   Distention
   Ischemia
General Assessment
 Scene Size-up & Initial
  Assessment
    Scene clues.
    Identify and treat life-threatening conditions.
 Focused History & Physical Exam
    Focused History
      Obtain SAMPLE History.
      Obtain OPQRST History.
        • Associated symptoms
        • Pertinent negatives
General Assessment
 Physical Exam
   General assessment and vital signs
   Abdominal assessment
    • Inspection, Auscultation, and Palpation
    • Cullen’s Sign
    • Grey-Turner’s Sign
General Treatment
 Maintain the airway.
 Support breathing.
    High-flow oxygen or assisted ventilations.
 Maintain circulation.
 Monitor vital signs and cardiac
  rhythm.
 Establish IV access.
 Transport in position of comfort.
Specific Illnesses
 The
  Gastrointestinal
  System
    Upper
     Gastrointestinal
     Tract
    Lower
     Gastrointestinal
     Tract
    Liver
    Gallbladder
    Pancreas
    Appendix
Upper Gastrointestinal
       Bleeding
 Causes
     Peptic Ulcer Disease
     Gastritis
     Varix Rupture
     Mallory-Weiss Tear
     Esophagitis
     Duodenitis
Upper Gastrointestinal
        Bleeding
 Signs & Symptoms
     General abdominal discomfort
     Hematemesis and melena
     Classic signs and symptoms of shock
     Changes in orthostatic vital signs
 Treatment
   Follow general treatment guidelines.
       Begin volume replacement using 2 large-bore IVs.
   Differentiate life-threatening from chronic problem.
Esophageal Varices
 Cause
   Portal
    Hypertension
     Chronic
      alcohol abuse
      and liver
      cirrhosis
     Ingestion of
      caustic
      substances
Esophageal Varices
 Signs & Symptoms
     Hematemesis, Dysphagia
     Painless Bleeding
     Hemodynamic Instability
     Classic Signs of Shock
 Treatment
   Follow General Treatment Guidelines.
       Aggressive Airway Management
       Aggressive Fluid Resuscitation
Acute Gastroenteritis
 Cause
   Damage to Mucosal GI Surfaces
     Pathologic inflammation causes hemorrhage and
      erosion of the mucosal and submucosal layers of
      the GI tract.
   Risk Factors
     Alcohol and tobacco use
     Chemical ingestion (NSAIDs, chemotherapeutics)
     Systemic infections
Acute Gastroenteritis
 Signs & Symptoms
     Rapid Onset of Severe Vomiting and Diarrhea
     Hematemesis, Hematochezia, Melena
     Diffuse Abdominal Pain
     Classic Signs of Shock
 Treatment
   Follow General Treatment Guidelines.
   Fluid Volume Replacement.
   Consider Administration of Antiemetics.
Gastroenteritis
 Similar to Acute Gastroenteritis
    Long-Term Mucosal Changes or Permanent
     Damage.
      Primarily due to microbial infection.
      More frequent in developing countries.
    Follow General Treatment Guidelines.
Peptic Ulcers
 Pathophysiology
   Erosions caused by
    gastric acid.
   Terminology based
    on the portion of
    tract affected.
   Causes:
     NSAID Use
     Alcohol/Tobacco Use
     H. pylori
Peptic Ulcers
 Signs & Symptoms
   Abdominal Pain
   Observe for signs of hemorrhagic rupture.
     Acute pain, hematemesis, melena

 Treatment
   Follow general treatment guidelines.
   Consider administration of histamine
    blockers and antacids.
Lower Gastrointestinal
       Bleeding
 Pathophysiology
   Bleeding distal to the ligament of Treitz
   Causes
       Diverticulosis
       Colon lesions
       Rectal lesions
       Inflammatory bowel disorder
Lower Gastrointestinal
       Bleeding
 Signs & Symptoms
     Determine acute vs. chronic.
     Quantity/color of blood in stool.
     Abdominal pain
     Signs of shock.
 Treatment
   Follow general treatment guidelines.
       Establish IV access with large-bore catheter(s).
Ulcerative Colitis
 Pathophysiology
   Causes Unknown
 Signs &
  Symptoms
   Abdominal Cramping
   Nausea, Vomiting,
    Diarrhea
   Fever or Weight Loss
 Treatment
   Follow general
    treatment guidelines.
Crohn’s Disease
 Pathophysiology
   Causes unknown.
   Can affect the entire
    GI tract.
   Pathologic
    inflammation:
      Damages mucosa.
      Hypertrophy and
       fibrosis of underlying
       muscle.
      Fissures and fistulas.
Crohn’s Disease
 Signs and Symptoms
   Difficult to differentiate.
      Clinical presentations vary drastically.
   GI bleeding, nausea, vomiting, diarrhea.
   Abdominal pain/cramping, fever, weight loss.
 Treatment
   Follow general treatment guidelines.
Diverticulitis
 Pathophysiology
   Inflammation of small
    outpockets in the
    mucosal lining of the
    intestinal tract.
   Common in the elderly.
   Diverticulosis.

 Signs &
  Symptoms
   Abdominal
    pain/tenderness.
   Fever, nausea, vomiting.
   Signs of lower GI
    bleeding.
 Treatment
   General treatment
    guidelines.
Hemorrhoids
 Pathophysiology
   Mass of swollen veins in
    anus or rectum.
   Idiopathic.

 Signs &
  Symptoms
   Limited bright red
    bleeding and painful
    stools.
   Consider lower GI
    bleeding.
 Treatment
   General treatment
    guidelines.
Bowel Obstruction
 Pathophysiology
   Blockage of the
    hollow space of the
    small or large
    intestines
   Hernias
Bowel Obstruction
 Pathophysiology
   Intussusception
Bowel Obstruction
 Pathophysiology
   Volvulus
Bowel Obstruction
 Pathophysiology
   Adhesions
Bowel Obstruction
 Pathophysiology
   Other Causes
       Foreign bodies, gallstones, tumors, bowel infarction
 Signs & Symptoms
     Decreased Appetite, Fever, Malaise
     Nausea and Vomiting
     Diffuse Visceral Pain, Abdominal Distention
     Signs & Symptoms of Shock
 Treatment
   Follow general treatment guidelines.
Accessory Organ Diseases
 GI Accessory Organs
     Liver
     Gallbladder
     Pancreas
     Vermiform Appendix
Appendicitis
 Pathophysiology
   Inflammation of the vermiform appendix.
   Frequently affects older children and young
    adults.
   Lack of treatment can cause rupture and
    subsequent peritonitis.
Appendicitis
 Signs & Symptoms
   Nausea, vomiting, and low-grade fever.
   Pain localizes to RLQ
    (McBurney’s point).
 Treatment
   Follow
    general
    treatment
    guidelines.
Cholecystitis
 Pathophysiology
   Inflammation of the
    Gallbladder
   Cholelithiasis
   Chronic
    Cholecystitis
     Bacterial infection
   Acalculus
    Cholecystitis
     Burns, sepsis,
      diabetes
     Multiple organ failure
Cholecystitis
 Signs & Symptoms
   URQ Abdominal Pain
     Murphy’s sign
   Nausea, Vomiting
   History of Cholecystitis
 Treatment
   Follow general treatment guidelines.
Pancreatitis
 Pathophysiology
   Inflammation of the Pancreas
     Classified as metabolic, mechanical, vascular, or
      infectious based on cause.
     Common causes include alcohol abuse, gallstones,
      elevated serum lipids, or drugs.
Pancreatitis
 Signs & Symptoms
   Mild Pancreatitis
      Epigastric Pain, Abdominal Distention, Nausea/Vomiting
      Elevated Amylase and Lipase Levels
   Severe Pancreatitis
      Refractory Hypotensive Shock and Blood Loss
      Respiratory Failure

 Treatment
   Follow general treatment guidelines
Hepatitis
 Pathophysiology
   Injury to Liver Cells
     Typically due to inflammation or infection.
   Types of Hepatitis
     Viral hepatitis (A, B, C, D, and E)
     Alcoholic hepatitis
     Trauma and other causes
   Risk Factors
Hepatitis
 Signs & Symptoms
     URQ abdominal tenderness
     Loss of appetite, weight loss, malaise
     Clay-colored stool, jaundice, scleral icterus
     Photophobia, nausea/vomiting
 Treatment
   Follow general treatment guidelines.
       Use PPE and follow BSI precautions
Gastroenterology
 General Pathophysiology,
  Assessment, and Management
 Specific Illnesses
   Upper Gastrointestinal Diseases
   Lower Gastrointestinal Diseases
   Accessory Organ Diseases

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Gastroenterology

  • 2. Sections  General Pathophysiology, Assessment, and Treatment  Specific Illnesses
  • 3. General Pathophysiology  General Risk Factors  Excessive Alcohol Consumption  Excessive Smoking  Increased Stress  Ingestion of Caustic Substances  Poor Bowel Habits  Emergencies  Acute emergencies usually arise from chronic underlying problems.
  • 4. Abdominal Pain  Types  Visceral  Somatic  Referred  Causes  Inflammation  Distention  Ischemia
  • 5. General Assessment  Scene Size-up & Initial Assessment  Scene clues.  Identify and treat life-threatening conditions.  Focused History & Physical Exam  Focused History  Obtain SAMPLE History.  Obtain OPQRST History. • Associated symptoms • Pertinent negatives
  • 6. General Assessment  Physical Exam  General assessment and vital signs  Abdominal assessment • Inspection, Auscultation, and Palpation • Cullen’s Sign • Grey-Turner’s Sign
  • 7. General Treatment  Maintain the airway.  Support breathing.  High-flow oxygen or assisted ventilations.  Maintain circulation.  Monitor vital signs and cardiac rhythm.  Establish IV access.  Transport in position of comfort.
  • 8. Specific Illnesses  The Gastrointestinal System  Upper Gastrointestinal Tract  Lower Gastrointestinal Tract  Liver  Gallbladder  Pancreas  Appendix
  • 9. Upper Gastrointestinal Bleeding  Causes  Peptic Ulcer Disease  Gastritis  Varix Rupture  Mallory-Weiss Tear  Esophagitis  Duodenitis
  • 10. Upper Gastrointestinal Bleeding  Signs & Symptoms  General abdominal discomfort  Hematemesis and melena  Classic signs and symptoms of shock  Changes in orthostatic vital signs  Treatment  Follow general treatment guidelines.  Begin volume replacement using 2 large-bore IVs.  Differentiate life-threatening from chronic problem.
  • 11. Esophageal Varices  Cause  Portal Hypertension  Chronic alcohol abuse and liver cirrhosis  Ingestion of caustic substances
  • 12. Esophageal Varices  Signs & Symptoms  Hematemesis, Dysphagia  Painless Bleeding  Hemodynamic Instability  Classic Signs of Shock  Treatment  Follow General Treatment Guidelines.  Aggressive Airway Management  Aggressive Fluid Resuscitation
  • 13. Acute Gastroenteritis  Cause  Damage to Mucosal GI Surfaces  Pathologic inflammation causes hemorrhage and erosion of the mucosal and submucosal layers of the GI tract.  Risk Factors  Alcohol and tobacco use  Chemical ingestion (NSAIDs, chemotherapeutics)  Systemic infections
  • 14. Acute Gastroenteritis  Signs & Symptoms  Rapid Onset of Severe Vomiting and Diarrhea  Hematemesis, Hematochezia, Melena  Diffuse Abdominal Pain  Classic Signs of Shock  Treatment  Follow General Treatment Guidelines.  Fluid Volume Replacement.  Consider Administration of Antiemetics.
  • 15. Gastroenteritis  Similar to Acute Gastroenteritis  Long-Term Mucosal Changes or Permanent Damage.  Primarily due to microbial infection.  More frequent in developing countries.  Follow General Treatment Guidelines.
  • 16. Peptic Ulcers  Pathophysiology  Erosions caused by gastric acid.  Terminology based on the portion of tract affected.  Causes:  NSAID Use  Alcohol/Tobacco Use  H. pylori
  • 17. Peptic Ulcers  Signs & Symptoms  Abdominal Pain  Observe for signs of hemorrhagic rupture.  Acute pain, hematemesis, melena  Treatment  Follow general treatment guidelines.  Consider administration of histamine blockers and antacids.
  • 18. Lower Gastrointestinal Bleeding  Pathophysiology  Bleeding distal to the ligament of Treitz  Causes  Diverticulosis  Colon lesions  Rectal lesions  Inflammatory bowel disorder
  • 19. Lower Gastrointestinal Bleeding  Signs & Symptoms  Determine acute vs. chronic.  Quantity/color of blood in stool.  Abdominal pain  Signs of shock.  Treatment  Follow general treatment guidelines.  Establish IV access with large-bore catheter(s).
  • 20. Ulcerative Colitis  Pathophysiology  Causes Unknown  Signs & Symptoms  Abdominal Cramping  Nausea, Vomiting, Diarrhea  Fever or Weight Loss  Treatment  Follow general treatment guidelines.
  • 21. Crohn’s Disease  Pathophysiology  Causes unknown.  Can affect the entire GI tract.  Pathologic inflammation:  Damages mucosa.  Hypertrophy and fibrosis of underlying muscle.  Fissures and fistulas.
  • 22. Crohn’s Disease  Signs and Symptoms  Difficult to differentiate.  Clinical presentations vary drastically.  GI bleeding, nausea, vomiting, diarrhea.  Abdominal pain/cramping, fever, weight loss.  Treatment  Follow general treatment guidelines.
  • 23. Diverticulitis  Pathophysiology  Inflammation of small outpockets in the mucosal lining of the intestinal tract.  Common in the elderly.  Diverticulosis.  Signs & Symptoms  Abdominal pain/tenderness.  Fever, nausea, vomiting.  Signs of lower GI bleeding.  Treatment  General treatment guidelines.
  • 24. Hemorrhoids  Pathophysiology  Mass of swollen veins in anus or rectum.  Idiopathic.  Signs & Symptoms  Limited bright red bleeding and painful stools.  Consider lower GI bleeding.  Treatment  General treatment guidelines.
  • 25. Bowel Obstruction  Pathophysiology  Blockage of the hollow space of the small or large intestines  Hernias
  • 29. Bowel Obstruction  Pathophysiology  Other Causes  Foreign bodies, gallstones, tumors, bowel infarction  Signs & Symptoms  Decreased Appetite, Fever, Malaise  Nausea and Vomiting  Diffuse Visceral Pain, Abdominal Distention  Signs & Symptoms of Shock  Treatment  Follow general treatment guidelines.
  • 30. Accessory Organ Diseases  GI Accessory Organs  Liver  Gallbladder  Pancreas  Vermiform Appendix
  • 31. Appendicitis  Pathophysiology  Inflammation of the vermiform appendix.  Frequently affects older children and young adults.  Lack of treatment can cause rupture and subsequent peritonitis.
  • 32. Appendicitis  Signs & Symptoms  Nausea, vomiting, and low-grade fever.  Pain localizes to RLQ (McBurney’s point).  Treatment  Follow general treatment guidelines.
  • 33. Cholecystitis  Pathophysiology  Inflammation of the Gallbladder  Cholelithiasis  Chronic Cholecystitis  Bacterial infection  Acalculus Cholecystitis  Burns, sepsis, diabetes  Multiple organ failure
  • 34. Cholecystitis  Signs & Symptoms  URQ Abdominal Pain  Murphy’s sign  Nausea, Vomiting  History of Cholecystitis  Treatment  Follow general treatment guidelines.
  • 35. Pancreatitis  Pathophysiology  Inflammation of the Pancreas  Classified as metabolic, mechanical, vascular, or infectious based on cause.  Common causes include alcohol abuse, gallstones, elevated serum lipids, or drugs.
  • 36. Pancreatitis  Signs & Symptoms  Mild Pancreatitis  Epigastric Pain, Abdominal Distention, Nausea/Vomiting  Elevated Amylase and Lipase Levels  Severe Pancreatitis  Refractory Hypotensive Shock and Blood Loss  Respiratory Failure  Treatment  Follow general treatment guidelines
  • 37. Hepatitis  Pathophysiology  Injury to Liver Cells  Typically due to inflammation or infection.  Types of Hepatitis  Viral hepatitis (A, B, C, D, and E)  Alcoholic hepatitis  Trauma and other causes  Risk Factors
  • 38. Hepatitis  Signs & Symptoms  URQ abdominal tenderness  Loss of appetite, weight loss, malaise  Clay-colored stool, jaundice, scleral icterus  Photophobia, nausea/vomiting  Treatment  Follow general treatment guidelines.  Use PPE and follow BSI precautions
  • 39. Gastroenterology  General Pathophysiology, Assessment, and Management  Specific Illnesses  Upper Gastrointestinal Diseases  Lower Gastrointestinal Diseases  Accessory Organ Diseases

Editor's Notes

  1. Visceral – dull, poorly localized pain the originates in the walls of hollow organs such as gallbladder or appendix Somatic – sharp localized pain that originates in walls of the body such as skeletal muscle Peritonitis – inflammation of the abd cavity such as caused by ruptured appendix Referred – originates in a region other than where it is felt Dissecting Abdominal Aortic Anuerism – pain is felt between the shoulder blades Diaphram Inflamation – pain in neck or shoulders Appendicitis – periumbilical pain
  2. Onset – was onset sudden or gradual? Sudden perferation while gradual is blockage Provocation – If pain lessens when the pt draws legs up to chest or lies on side usually indicates peritoneal inflammation of GI origin Quality – Localized tearing pain associated with organ rupture Dull steadily increasing may indicate bowel obstruction Sharp flank pain indicative of kidney stone Region/Radiation – Severity – pain worsens with worsening pathology (ischemia, inflammation, stretching) Time – Any pain lasting longer than 6 hours is considered surgical emergency Associated Symptoms – nausea, vomiting, bright red or coffee ground emesis, any changes in bowel habits, constiption, diarrhea, dark tarry stools loss of appetite or weight loss Pertinenet Negatives Pain in lower abd pelvis area may mean problems with reproductive system Inferior MI can irritate diaphragm and cause referred pain in shoulder and neck. Ask about cardiac history Chest pain may be GI referred pain – ie gastroesophageal reflux, gastric ulcers. Ask pt have they ever experienced pain like this before.
  3. Physical Exam – posture and general appearance are key. They usually lay still often in fetal position because moving around causes more pain Distension may be an obvious sign. May be caused by build up of free air due to bowel obstruction. Abd can hold 4 o 6 L blood before any noticable change. Periumbilical ecchimosis (cullen’s sign) ecchymosis in flank (Grey-Turner’s sign Palpate – from area of no pain to area of pain. Stop palpating if you feel pulsating mass.
  4. Note that any pain lasting longer than 6 hours is classified as a surgical emergency. Establish IV to replace fluids. NPO. Anti emetic helpful.
  5. Upper GI include esophagus stomach duodenum to ligament of treitz. Appendix is part of the large intestine.
  6. Upper GI bleed – peptic ulser disease, gastritis, esophageal varises, mallory-weiss tear (caused by vomiting). If ulcer erodes through the gastic mucosa can be life threatening. Blood in GI tract causes irritation and vomiting (hematemesis). Bleeding may be light or heavy and life threatening. Signs of shock, syncope, tilt test >10mmHg change. Maintain airway and prevent aspiration. Circulatory support. 20 cc/kg infusion Esophageal Varices – swollen vein of esophagus often rupture. Caused by increased portal vein pressure due to liver disease. Acute Gastroenteritis – inflammation of the stomach and intestines with asociated acute vomitingor diarrhea. Inflammation causes hemorrhage and erosion of the mucosal and submucosal layers of the GI tract which can damage villa that absorb water and nutrients.caused by alcohol abuse, asprin, stress, chemo agents, salmonella, staphylococcus. Pt may be hemodynamicaly unstable, electrolyte imbalance can cause chest pain and disrythmias. c/o widespread diffuse abd pain. Suction airway as needed and replace fluids Chronic Gastroenteritis – non acute inflammation of the gastrointenstinal mucosa due primarily to infection ie E. coli Peptic Ulcers – erosions caused by gastric acid
  7. Lower GI Disease – rarely result in massive hemorrhage like those that occur in the upper GI Lower GI Bleed Ulcerative Colitis – inflammatory bowel disorder (IBD) of colon or large intestine Crohn’s Disease – IBD of small intestine, s/s diffuse abd cramping/pain, GI bleed, weight lose, nausea vomiting and diarrhea. Absence of Abd sounds signifies obstruction which requires surgery Diverticulitis – inflammation of diverticula (small outpouchings in the mucosal lining of the intestinal tract. Seeds popcorn and other things can get trapped and cause inflammation, bleeding and peritonitis) s/s low grade fever, lower left quad abd pain nausea and vomiting Hemorrhoids – small mass of swolen veins in the anus or rectum. (recked him, damn near killed him) rarely do they cause significant hemorrhage. May call 911 because of bleeding and pain. Alcoholics have increased risk Bowel Obstruction – blockage within the intestine either partial or complete. Can be caused by herniation, intussuseption, adhesion, volvulus twisting, prior surgery. Pt present with diffuse visceral pain, s/s shock (pale clammy skin tachycardia Alt LOC, hypotension. Can result in peritonitis if ruptured. Vomit may contain bile or smell like feces.
  8. Appendicitis – inflammation of juncture between large and small intestine. (p. 244) affects mostly older children and young adults. The appendix can become inflammed and infected due to blockage and if not treated may rupture spilling contents into peritoneal cavity causing peritonitis. s/s pain lower right quandrant (McBurney’s point) Cholecystitis – inflammation of gallbladder. Usually caused by gallstones cholesterol or bilirubin based. Common among obese woman with more than one child. The gallbladder releases bile with removes cholesterol from body. s/s right upper abd pain. Pancreatitis – caused by alcohol abuse, gallstones, high cholesterol. Pancrease produces digestive enzymes as well as insulin and glucagon. When digestive enzymes back up into pancrease causing inflammation. s/s left upper quad abd pain may radiate to back. Nausea and vomiting. Hepatitis – injury to liver infectious A,B,C,D,E alcohol cirrosis, trauma. c/o upper right abd pain, loss of appetitie and weight loss, jaundice. Liver filters and detoxifies blood, and turns glucose into glycogen. Carefully consider pharmacological admin because liver breaks down many active drug metabolites.