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Pathology cell injury i

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MBBS IMS MSU
MBBS IMS MSU

cell injury

Health & Medicine
1 of 64
Cell Injury I – Cell Injury and Cell Death Dept. of Pathology
Key Concepts ,[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Key Concepts (cont’d) ,[object Object],[object Object],[object Object]
Cell Injury – General Mechanisms ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cell Injury – General Mechanisms ,[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Causes of Cell Injury and Necrosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Reversible Injury ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Irreversible Injury ,[object Object],[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Funky mitochondria
Cell Injury ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Clinical Correlation ,[object Object],[object Object]
Free Radicals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Examples of Free Radical Injury ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanism of Free Radical Injury ,[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Morphology of Cell Injury – Key Concept ,[object Object]
© 2005 Elsevier Downloaded from: StudentConsult (on 8 September 2010 02:58 PM)
Reversible Injury -- Morphology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Irreversible Injury -- Morphology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Irreversible Injury – Nuclear Changes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Karyolysis & karyorrhexis -- micro
Types of Cell Death ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Apoptosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Apoptosis – Morphologic Features ,[object Object],[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:59 PM) © 2005 Elsevier
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Downloaded from: StudentConsult (on 8 September 2010 02:59 PM) © 2005 Elsevier
Apoptosis – Micro
Types of Necrosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Coagulative Necrosis ,[object Object],[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Splenic infarcts -- gross
Infarcted bowel -- gross
Myocardium photomic
Adrenal infarct -- Micro
3 stages of coagulative necrosis (L to R) -- micro
Liquefactive Necrosis ,[object Object],[object Object]
Lung abscesses (liquefactive necrosis) -- gross
Liver abscess -- micro
Liquefactive necrosis -- gross
Liquefactive necrosis of brain -- micro
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Macrophages cleaning liquefactive necrosis -- micro
Caseous Necrosis ,[object Object],[object Object],[object Object],[object Object]
Caseous necrosis -- gross
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Extensive caseous necrosis -- gross
Caseous necrosis -- micro
Enzymatic Fat Necrosis ,[object Object],[object Object],[object Object]
Enzymatic fat necrosis of pancreas -- gross
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier
Fat necrosis -- micro
Gangrenous Necrosis ,[object Object],[object Object],[object Object]
Gangrene -- gross
Wet gangrene -- gross
Gangrenous necrosis -- micro
Fibrinoid Necrosis ,[object Object],[object Object]
Downloaded from: StudentConsult (on 8 September 2010 02:58 PM) © 2005 Elsevier

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