NovioTech BV is a startup company founded by Hans Hanssen and others to commercialize two technologies: 1) A glucose sensor technology called NovioSense that measures glucose levels in tear fluid using a continuous, non-invasive method. 2) A novel hydrogel technology called NovioHelix that forms a gel with programmable transition temperatures and nano-pores for use in biomedical applications like wound care. The company has raised €1.1 million in funding and aims to have functional prototypes of both technologies within 12 months.

1. NovioTech BV
Technology to the Market
From Glucose Sensor to Hydrogel
Hans Hanssen (CTO)
Presented 30 June 2011 to Valorisation UMC Radboud

2. About NovioTech BV
• Shareholders:
• Tweehuysen Holding BV
• Hanssen Investment and Consultancy BV
• Prof. Jan van Hest
• Prof. Alan Rowan
• Scientific Advisor: Prof Roeland Nolte
www.noviotech.com

3. About the Speaker: Hans Hanssen
• Former CEO of MCTEC
• Co-Founder of DSE BV, Eyetube BV, MCTEC BV,
NovioTech BV
• Business Advisor to EPFlex GmBH, Nano4Imaging
BV, Encapson BV

4. Outline of the Talk
• NovioSense – Glucose Sensor Technology
• NovioHelix – Novel Thermogel Technology

6. Diabetes
• At this moment World Health Organization estimates 5-7% of the worldpopulation
has diabetes.
• This will increase within the next 20 years to 300 million.
• Diabetes can lead to:
– Heart disease and stroke
– High blood pressure
– Blindness
– Kidney disease
– Nervous system disease (Neuropathy)
– Amputation

7. Standard sensors
• Involves finger-pricking for sampling
• Not-continuous monitoring

10. Concept sensor
A
V
Electrochemical reactions E°/V
WE: H2O2  2H+ + O2 + 2e- 0.695
Counter Working Reference CE: 2H+ + ½O2 + 2e-  H2O
Electrode Electrode Electrode RE: Ag(s) + Cl-  AgCl(s) 0.22233

11. 9.00E-07
y = 5.36E-07x + 2.10E-07
8.00E-07 R2 = 9.96E-01
7.00E-07
6.00E-07
Current (A)
5.00E-07
4.00E-07
3.00E-07
2.00E-07
1.00E-07
0.00E+00
0 0.5 1
Glucose conc. (mM)
The resulting current is linear within
the concentration regime of glucose
levels in tear fluid

13. Semi-Continuous Glucose Monitoring
Sending signal to
receiver in glasses
Amplifying signal and
transmition to insulin pump

14. Project Status
Patent Pending: NovioTech Assignee
Contact with Major Players in the Glucose Management Industry
Raised €1.1M of Inter Regional Funding
Goal is Functional Prototypes in 12 Months From Now

16. Warm
Cool
Gel formation at up to 99.98% water
Programmable transition temperatures
Optically Transparent
Biocompatible
Forms Nano-Pores (100-250nm)
Stiffness from (10 - 1000Pa)

18. Market Opportunities Based on Bulk Properties

20. Low Hanging Fruit: NanoWipe
Contacts with Potential End Users (DSM Resolve) and Instrument
Manufacturers (NanoSight UK)

21. 3D Tissue Culture Medium

22. Wound Care

23. Project Status
Identified Dedicated Project Manager
Patent Pending: NovioTech has Exclusive License
Promising New Thermo Responsive Nano Material
Identify Most Promising Market Areas
Early Prototype NanoWipe
Proof of Principle BioMedical Applications Underway

24. Wound Management