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Bradycardias
Salah Abusin, MD, MRCP, ABIM, ABIM (Card)
Interventional Cardiologist
Dubuque, IA, USA
Bradycardias
• SA node dysfunction or
Sick Sinus Syndrome
– Inappropriate sinus
bradycardia
– Sinoatrial exit Block
– Sinus Pause/Arrest
– Tachycarda/Bradycardia
syndrome
– Persistent Atrial Standstill
• AV Blocks
– First Degree
– Second Degree
• Mobitz I
• Mobitz II
• 2:1 Block
– Third Degree
– High Grade AV Block
Sinoatrial Node dysfunction
• Inappropriate sinus bradycardia
• Sinoatrial exit Block
• Sinus Pause/Arrest
• Tachycarda/Bradycardia syndrome
Causes - Intrinsic
• Idiopathic degenerative disease
• Coronary Artery Disease
• Cardiomyopathy
• Hypertension
• Infiltrative Disorders (amyloidosis etc..)
• Collagen Vascular Disorders (scleroderma etc.)
• Inflammatory Processes (myocarditis)
• Surgical Trauma
• Musculoskeletal disorders (myotonic dystrophy)
• Congenital heart disease (postoperative or
absence of correction)
Causes – Extrinsic - 1
• Medication
– BBs, CCBs, digoxin
– Clonidine, alpha methyldopa, reserpine
– Antiarrhythmics Type
• IA (quinidine, procainamide)
• IC (flecainide)
• III (amiodarone)
– Lithium
Causes – Extrinsic - 2
• Autonomic influences
– High vagal tone
– Carotid sinus syndrome
– Vasovagal syncope
• Electrolyte abnormalities
– Hyperkalemia, hypercarbia, hypothyroidism
• Increase intracranial pressure
• Hypothermia
• Sepsis
Sinoatrial Node dysfunction
• Inappropriate sinus bradycardia
• Sinus Pause/Arrest
• Sinoatrial exit Block
• Tachycarda/Bradycardia syndrome
Inappropriate Sinus Bradycardia
Chronotropic Incompetence
• HR<60 that doesn’t increase appropriately with
exercise
• Usually defined as failure to attain 80% of
maximal age predicted HR (MAHR) on exercise
testing
• MAHR = 220 – Age
• e.g. failure to reach a HR of 120 in a 70 year old
patient
Sinus bradycardia
Sinoatrial Node dysfunction
• Inappropriate sinus bradycardia
• Sinus Pause/Arrest
• Sinoatrial exit Block
• Tachycarda/Bradycardia syndrome
Sinus Pause/Arrest
• Defined as absence of a sinus beat for >=3
seconds while AWAKE
• SA node fails to discharge so no atrial activity
occurs
Sinus Pause/Arrest
Sinoatrial Node dysfunction
• Inappropriate sinus bradycardia
• Sinus Pause/Arrest
• Sinoatrial exit Block
• Tachycarda/Bradycardia syndrome
Sinoatrial Exit Block
• SA node discharges an impulse that does NOT
result in atrial activity
Sinoatrial Exit Block
Sinoatrial Node dysfunction
• Inappropriate sinus bradycardia
• Sinus Pause/Arrest
• Sinoatrial exit Block
• Tachycarda/Bradycardia syndrome
Tachycardia-Bradycardia Syndrome
• Bradycardia/sinus pauses interspersed with
atrial arrhythmias (AFL, A fib, A tach)
• Sinus arrest manifests after termination of
atrial arrhythmia (spontaneously or after DCCV)
• Sinus Node Recovery Time (SNRT) uses the
above observation to assess SA node function
in EP studies
Tachycardia-Bradycardia Syndrome
Hurst the Heart
12th
Edition
Indications for pacing in SND
• Class I (recommended)
– SND with documented symptoms
– SND due to irreversible factors or due to essential
drug therapy
– Chronotropic incompetence
• Class III (NOT recommended)
– Asymptomatic
Bradycardias
• SA node dysfunction or
Sick Sinus Syndrome
– Inappropriate sinus
bradycardia
– Sinoatrial exit Block
– Sinus Pause/Arrest
– Tachycarda/Bradycardia
syndrome
– Persistent Atrial Standstill
• AV Blocks
– First Degree
– Second Degree
• Mobitz I
• Mobitz II
• 2:1 Block
– Third Degree
– High Grade AV Block
AV Blocks
• First Degree
• Second Degree
– Mobitz I
– 2:1 Block
– Mobitz II
• Third Degree
• High Grade AV Block
First Degree AV Block
• PR interval > 200msec
• If QRS is normal, block is usually at the level of
the AV node
• If QRS shows bundle branch block, block
maybe in His-Purkinje System
First degree AV block
Management
• Usually no specific therapy is required
Second Degree Heart Block
Mobitz I or Wenchebach
• Progressive Prolongation of the PR interval
and shortening of the RR interval until a P
wave is blocked
• RR interval containing the non conducted P
wave is less than two PP intervals
• PR interval longer after the non conducted P
wave
• Grouped beating
Second Degree – Mobitz I
P P P P P P
Causes
• Normal
• Athletes
• Medications
• Myocardial Infarction
(inferior wall)
• Acute rheumatic fever
• Myocarditis
Features
• Usually asymptomatic
• Usually narrow QRS complex
 block at AV node
• The presence of bundle branch
block suggests the possibility
of block below the AV node in
His Purkinje system
Management
• Usually do not require permanent pacing
Second Degree – Mobitz II
• Constant PR interval with intermittent
nonconducted P wave and no evidence for PACs
• RR interval between non conducted P waves is
equal to two PP intervals
• Each QRS is preceded by multiple P waves
• 3:1, 4:1 also called high grade AV block
• Other variations include 3:2
• 2:1 block maybe Mobitz I or Mobitz II
High Grade AV Block
PP PP
Second Degree Heart Block
2:1 Block
Management
• Usually require permanent pacing especially if
symptomatic due to high likelihood of
progression to high grade AV block and third
degree AV block
Differentiating mechanism of 2:1 block
Feature Mobitz I Mobitz II
QRS duration Narrow Wide
Response to increasing
HR & AV conduction i.e.
exercise, atropine
Improves Worsens
Response to decreasing
HR & AV conduction i.e.
carotid sinus massage
Worsens Improves
Acute MI Inferior Anterior
Third Degree AV block
• Atrial impulses consistently fail to reach the
ventricles, resulting in atrial and ventricular
rhythms that are independent of each other
• PR interval varies
• PP and RR intervals are constant
• Ventriculophasic sinus arrhythmia
– PP interval containing QRS is shorter than PP
interval without a QRS complex
Third Degree AV block
P P P P P P P P P PP
Escape Rhythms
• Junctional
– Usually narrow (may be wide if underlying BBB)
– 40-60/min
• Ventricular Escape Rhythm
– Wide complex
– 30-40/min (range 20-50)
Causes
• Myocardial Infarction
– Inferior wall, usually transient, associated with a
stable junctional escape rhythm
– Anterior wall, usually permanent
• Degenerative Disease
• Infiltrative Disease (amyloid, sarcoid)
• Endocarditis (Aortic Root abscess)
• Hyperkalemia
• Medication
• Post Cardiac Surgery
Management
• Usually require permanent pacing
Acclerated Idioventricular rhythm
Acclerated Idioventricular rhythm
• Regular Wide complex rhythm
• 60-110/min
• AV dissociation
• Benign phenomenon
• Causes
– Normal
– Coronary reperfusion
– Digoxin toxicity
Problems
3rd
degree AV block, junctional escape
Second Degree Mobitz I
P P P P P P P P P P P
3rd
degree AV block, junctional escape
P P P P P P P P P P
3rd
degree AV block, junctional escape
or high grade AV block
Problem
• 50 year old female with no PMH presents with
acute onset of shortness of breath on exertion
of 4 days duration
• HR 50/min, BP 140/80
• Initial ECG sinus bradycardia
• TropI 1.2
Sinus arrest with ventricular escape
Sinus arrhythmia
Problem
• 65 year old male presented with 4 day history
of shortness of breath on exertion, orthopnea
and PND
• HR 50/min, regular, BP 150/70
Atrial Fibrillation with 3rd
degree AV
block & junctional escape
Single Chamber Ventricular Pacing at
45/min with complete heart block
Dual Chamber Pacing with marked
anterolateral ST depression
Sick Sinus Syndrome
Sinus pauses with interspersed short runs
of Atrial Fibrillation
Thank You

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ARLC 2014 - Bradycardias

  • 1. Bradycardias Salah Abusin, MD, MRCP, ABIM, ABIM (Card) Interventional Cardiologist Dubuque, IA, USA
  • 2. Bradycardias • SA node dysfunction or Sick Sinus Syndrome – Inappropriate sinus bradycardia – Sinoatrial exit Block – Sinus Pause/Arrest – Tachycarda/Bradycardia syndrome – Persistent Atrial Standstill • AV Blocks – First Degree – Second Degree • Mobitz I • Mobitz II • 2:1 Block – Third Degree – High Grade AV Block
  • 3.
  • 4. Sinoatrial Node dysfunction • Inappropriate sinus bradycardia • Sinoatrial exit Block • Sinus Pause/Arrest • Tachycarda/Bradycardia syndrome
  • 5. Causes - Intrinsic • Idiopathic degenerative disease • Coronary Artery Disease • Cardiomyopathy • Hypertension • Infiltrative Disorders (amyloidosis etc..) • Collagen Vascular Disorders (scleroderma etc.) • Inflammatory Processes (myocarditis) • Surgical Trauma • Musculoskeletal disorders (myotonic dystrophy) • Congenital heart disease (postoperative or absence of correction)
  • 6. Causes – Extrinsic - 1 • Medication – BBs, CCBs, digoxin – Clonidine, alpha methyldopa, reserpine – Antiarrhythmics Type • IA (quinidine, procainamide) • IC (flecainide) • III (amiodarone) – Lithium
  • 7. Causes – Extrinsic - 2 • Autonomic influences – High vagal tone – Carotid sinus syndrome – Vasovagal syncope • Electrolyte abnormalities – Hyperkalemia, hypercarbia, hypothyroidism • Increase intracranial pressure • Hypothermia • Sepsis
  • 8. Sinoatrial Node dysfunction • Inappropriate sinus bradycardia • Sinus Pause/Arrest • Sinoatrial exit Block • Tachycarda/Bradycardia syndrome
  • 9. Inappropriate Sinus Bradycardia Chronotropic Incompetence • HR<60 that doesn’t increase appropriately with exercise • Usually defined as failure to attain 80% of maximal age predicted HR (MAHR) on exercise testing • MAHR = 220 – Age • e.g. failure to reach a HR of 120 in a 70 year old patient
  • 11. Sinoatrial Node dysfunction • Inappropriate sinus bradycardia • Sinus Pause/Arrest • Sinoatrial exit Block • Tachycarda/Bradycardia syndrome
  • 12. Sinus Pause/Arrest • Defined as absence of a sinus beat for >=3 seconds while AWAKE • SA node fails to discharge so no atrial activity occurs
  • 14. Sinoatrial Node dysfunction • Inappropriate sinus bradycardia • Sinus Pause/Arrest • Sinoatrial exit Block • Tachycarda/Bradycardia syndrome
  • 15. Sinoatrial Exit Block • SA node discharges an impulse that does NOT result in atrial activity
  • 17. Sinoatrial Node dysfunction • Inappropriate sinus bradycardia • Sinus Pause/Arrest • Sinoatrial exit Block • Tachycarda/Bradycardia syndrome
  • 18. Tachycardia-Bradycardia Syndrome • Bradycardia/sinus pauses interspersed with atrial arrhythmias (AFL, A fib, A tach) • Sinus arrest manifests after termination of atrial arrhythmia (spontaneously or after DCCV) • Sinus Node Recovery Time (SNRT) uses the above observation to assess SA node function in EP studies
  • 20. Indications for pacing in SND • Class I (recommended) – SND with documented symptoms – SND due to irreversible factors or due to essential drug therapy – Chronotropic incompetence • Class III (NOT recommended) – Asymptomatic
  • 21. Bradycardias • SA node dysfunction or Sick Sinus Syndrome – Inappropriate sinus bradycardia – Sinoatrial exit Block – Sinus Pause/Arrest – Tachycarda/Bradycardia syndrome – Persistent Atrial Standstill • AV Blocks – First Degree – Second Degree • Mobitz I • Mobitz II • 2:1 Block – Third Degree – High Grade AV Block
  • 22. AV Blocks • First Degree • Second Degree – Mobitz I – 2:1 Block – Mobitz II • Third Degree • High Grade AV Block
  • 23. First Degree AV Block • PR interval > 200msec • If QRS is normal, block is usually at the level of the AV node • If QRS shows bundle branch block, block maybe in His-Purkinje System
  • 25. Management • Usually no specific therapy is required
  • 26. Second Degree Heart Block Mobitz I or Wenchebach • Progressive Prolongation of the PR interval and shortening of the RR interval until a P wave is blocked • RR interval containing the non conducted P wave is less than two PP intervals • PR interval longer after the non conducted P wave • Grouped beating
  • 27. Second Degree – Mobitz I P P P P P P
  • 28. Causes • Normal • Athletes • Medications • Myocardial Infarction (inferior wall) • Acute rheumatic fever • Myocarditis Features • Usually asymptomatic • Usually narrow QRS complex  block at AV node • The presence of bundle branch block suggests the possibility of block below the AV node in His Purkinje system
  • 29. Management • Usually do not require permanent pacing
  • 30. Second Degree – Mobitz II • Constant PR interval with intermittent nonconducted P wave and no evidence for PACs • RR interval between non conducted P waves is equal to two PP intervals • Each QRS is preceded by multiple P waves • 3:1, 4:1 also called high grade AV block • Other variations include 3:2 • 2:1 block maybe Mobitz I or Mobitz II
  • 31. High Grade AV Block
  • 32. PP PP Second Degree Heart Block 2:1 Block
  • 33. Management • Usually require permanent pacing especially if symptomatic due to high likelihood of progression to high grade AV block and third degree AV block
  • 34. Differentiating mechanism of 2:1 block Feature Mobitz I Mobitz II QRS duration Narrow Wide Response to increasing HR & AV conduction i.e. exercise, atropine Improves Worsens Response to decreasing HR & AV conduction i.e. carotid sinus massage Worsens Improves Acute MI Inferior Anterior
  • 35. Third Degree AV block • Atrial impulses consistently fail to reach the ventricles, resulting in atrial and ventricular rhythms that are independent of each other • PR interval varies • PP and RR intervals are constant • Ventriculophasic sinus arrhythmia – PP interval containing QRS is shorter than PP interval without a QRS complex
  • 36. Third Degree AV block P P P P P P P P P PP
  • 37. Escape Rhythms • Junctional – Usually narrow (may be wide if underlying BBB) – 40-60/min • Ventricular Escape Rhythm – Wide complex – 30-40/min (range 20-50)
  • 38. Causes • Myocardial Infarction – Inferior wall, usually transient, associated with a stable junctional escape rhythm – Anterior wall, usually permanent • Degenerative Disease • Infiltrative Disease (amyloid, sarcoid) • Endocarditis (Aortic Root abscess) • Hyperkalemia • Medication • Post Cardiac Surgery
  • 39. Management • Usually require permanent pacing
  • 41. Acclerated Idioventricular rhythm • Regular Wide complex rhythm • 60-110/min • AV dissociation • Benign phenomenon • Causes – Normal – Coronary reperfusion – Digoxin toxicity
  • 43. 3rd degree AV block, junctional escape
  • 45. P P P P P P P P P P P 3rd degree AV block, junctional escape
  • 46. P P P P P P P P P P 3rd degree AV block, junctional escape or high grade AV block
  • 47. Problem • 50 year old female with no PMH presents with acute onset of shortness of breath on exertion of 4 days duration • HR 50/min, BP 140/80 • Initial ECG sinus bradycardia • TropI 1.2
  • 48. Sinus arrest with ventricular escape
  • 50. Problem • 65 year old male presented with 4 day history of shortness of breath on exertion, orthopnea and PND • HR 50/min, regular, BP 150/70
  • 51. Atrial Fibrillation with 3rd degree AV block & junctional escape
  • 52. Single Chamber Ventricular Pacing at 45/min with complete heart block
  • 53. Dual Chamber Pacing with marked anterolateral ST depression
  • 54.
  • 55. Sick Sinus Syndrome Sinus pauses with interspersed short runs of Atrial Fibrillation

Editor's Notes

  1. Other definitions, failure to attain 85%, 75%
  2. HR 46/min Put her on a treadmill reached HR of 137/min
  3. 3.4 and 4.8 second pauses Patient had acute coronary syndrome with lesion in proximal RCA involving the branch to the SA node, placed a dual chamber pacemaker
  4. ACC/AHA guidelines
  5. Prolongation of of the PR interval &amp;gt; 200ms, 1:1 conduction, P before every QRS complex, both P and QRS are normal
  6. Progressive prolongation of the PR interval terminated in a non conducted P wave