2. Wheeze
ο A high-pitched whistling/musical sound produced by
the passage of air through narrowed airways/ bronchi
ο Louder during expiration
ο A manifestation of lower respiratory tract obstruction
ο Site of obstruction may be anywhere from the
intrathoracic trachea to the small bronchi or large
bronchioles
ο Sound is generated by turbulence in larger airways that
collapse with forced expiration
3. Wheezing in Children
ο Episodic wheezing and cough are common in children
ο Infants and young children (<3 years) are especially
prone to wheezing
5. Wheeze
ο Acute
ο Inhaled foreign body
ο Acute infection
ο Acute allergic reaction
ο Recurrent
ο Respiratory System
ο Asthma
ο Other causes*
β’ Non-respiratory system
ο Heart failure (left to right shunts)
ο GERD (milk inhalation)
6. Categories of Wheezing in children
<5 years
ο Transient early wheezing
ο Persistent early-onset wheezing
ο Late-onset wheezing
7. Transient early wheezing
ο Result from small airways being obstruct due to
inflammation secondary to viral infections.
ο β lung function from birth
ο Risk factors: mother smoking during and/ or
after pregnancy and prematurity
ο Common in β
ο Resolves by 5 years old
8. Non atopic wheezing
ο Have normal lung function in early life
ο Lower respiratory illness due to viral infection
leads to β wheezing during the 1st 10 years of life.
ο cause less severe persistent wheezing
ο symptoms improve during adolescence
9. Ig E-mediated wheezing
(atopic asthma)
ο Lung function β normal at birth
ο Recurrent wheeze develops with allergic sensitisation
ο β blood Ig E & positive skin prick tests to common
allergens
ο Persistence of symptoms & β lung function later in
childhood.
ο Risk factors:
ο Positive family history
ο Allergy
ο History of eczema
10. Other causes of recurrent wheeze
in infancy
ο Recurrent aspiration of feeds
ο Cystic fibrosis
o Inhaled foreign body
ο Congenital abnormality of lung, airway or heart
ο Idiopathic
ο Cowβs milk protein intolerance
11. History Taking
Wheeze
ο Age of onset
ο Duration-Acute or recurrent
ο Precipitating factors
ο URTI symptoms
ο Contact with URTI patient
ο Triggers for asthma - ( A,V,C,D,E,F)
ο History of atopy
ο Associated symptoms
ο Rapid breathing
ο Cough- dry or productive? Sputum colour?
ο Chest tightness
ο Nausea or vomiting
ο Cyanosis
12. ο Pattern of symptoms
ο Daytime/ nocturnal symptoms
ο Exercise induced
ο Severity
ο On any medication? Types?
ο Relieved with medication
ο Restriction of daily activities
ο Sleep disturbances
13. ο Systemic Review
ο General condition - LOA, LOW
ο Atopy - angioedema, allergic rhinitis, allergic
conjunctivitis, eczema, urticaria
ο Past Medical History
ο Number of admission to the hospital
ο Number of admission due to similar problem
ο Last admission due to similar problem
ο Duration of stays
ο Medication given and discharge medication
ο History of prolonged URTI symptoms
14. ο Birth History
ο Antenatal: intrauterine infection
ο Intrapartum: Prematurity
ο Postnatal: Prolonged labour, NNJ, congenital pulmonary disease
ο Immunization History
ο Family History
ο Asthma
ο Atopy
ο CHD
ο Cystic fibrosis
ο Social History
ο School performance
ο Daily activities
ο Social interaction
ο Anyone smoking at home
ο Location of house
ο Environment condition: Pets, flower, dust
ο Drug and Allergy History
15. Physical Examination
ο General condition: alert, conscious, drowsiness, irritability
ο Signs of respiratory distress
ο Sitting propped up
ο Shortness of breath
ο Use of accessory muscles
ο Audible wheeze
ο Central cyanosis
ο Vital signs
ο Anthropometry measurements
ο O2 therapy: : nasal prong, face mask, high-flow
mask, nebulizer
ο Speech: sentences, phrases or words
21. Asthma (Protocol)
ο Chronic airway inflammation leading to β airway
responsiveness that leads to recurrent episodes of
wheezing, breathlessness, chest tightness and
coughing particularly night / early morning.
often associated with widespread but variable
airway obstruction that is often reversible either
spontaneously or with treatment.
26. Tests for Diagnosis and Monitoring
of Asthma
ο Spirometry β FEV1 and FVC
ο PEFR
ο To confirm the diagnosis of asthma ( improvement of >15%
after bronchodilator)
ο useful for assessing the severity of asthma
ο response of the patient to therapy
ο Normal value are available & relate to height
ο To identify environmental (including occupational) causes of
asthma symptoms
ο Skin prick test with allergens
ο Exercise challenge
32. Criteria for Admission
ο Failure to respond to standard home treatment
ο Failure of those with mild or moderate acute asthma to
respond to nebulised Ξ²2-agonists
ο Relapse within 4 hrs of nebulised Ξ²2-agonists
ο Severe acute asthma
39. Upon Discharge
ο Review asthma medications
ο Provide Asthma Action Plan
ο How to recognize worsening asthma
ο How to treat worsening asthma
ο How & when to seek medical attention
ο Schedule regular follow-ups to monitor asthma control
40. Asthma Education
ο To provide the person with asthma, their family and other
caregivers with suitable information and training so that they
can keep well and adjust treatment according to a medication
plan developed with the health care professional
ο Asthma Education should include :
ο What is asthma?
ο Types of treatment available
ο Drugs β βrelieversβ & βcontrollersβ
ο Inhalation devices β how to use them
ο Trigger factors and how to avoid them
ο Personal Asthma Action Plan
41. Prevention
ο Identifying and avoiding the following common
triggers may be useful
ο Environmental allergens (house dust mites, animal
dander, insects, mould and pollen)
ο Cigarette smoking
ο Respiratory tract infections
ο Food allergy β uncommon trigger, occurring in 1-2% of
children
ο vigorous exercise βshould not restrict
42. Assessment of level of control
Management based on control
Drug therapy βtypes,dosages,delivery
43. ο Assessment of severity
ο Classification based on frequency, chronicity and severity of
symptoms
ο Management according to severity:
Daytime Limitatio Nocturnal Need for Lung Exacerba
symptoms of symptoms/ reliever function tions
activites awakening tests
s
Controlled None None None None None None
All of the
following:
Partly >2 / week Any Any 2/week <80% β₯1 a year
controlled predicted
any measure or
present in
personal
any wk
best
Uncontroll β₯3 features of partly controlled asthma present in any week 1/week
ed
44. Management of Chronic Asthma
ο Goal:
ο Achieve and maintain control of symptoms
ο Maintain normal activity levels, including exercise
ο Maintain pulmonary function as close to normal as
possible
ο Prevent asthma exacerbations
ο Avoid adverse effects from asthma medications
ο Prevent asthma mortality
46. Chronic asthma
NOTE:
1. Patients should commence treatment at the step most
appropriate to the initial severity.
A short rescue course of prednisolone may help establish
control promptly.
2. Explain to parents and patient about asthma and all therapy
3. Ensure both compliance and inhaler technique optimal before
progression to next step.
4. Step-up; assess patient after 1 month of initiation of treatment
and if control is not adequate, consider step-up after looking
into factors as in 3
5. Step-down; review treatment every 3 months and if control
sustained for at least 4-6 months, consider gradual treatment
reduction.
55. Monitoring
οΆ Assessment during follow-up
ο Assess severity
ο Response to treatment
ο Interval symptoms
ο Frequency and severity of acute exacerbation
ο Morbidity secondary to asthma
ο Quality of life
ο PER monitoring on each visit
ο Compliance
ο Frequency, technique, reason and excuses
ο Education
ο Technique, factual information, written action plan, PEF monitoring
may not be practical for all asthmatics but is essential especially for
those have poor perception of symptoms and those with life
threatening attacks
56.
57. References
ο Pediatric Protocols
ο Illustrated Textbook of Pediatric
ο GINAReport 2009
ο GINA_Under 5 Report 2009
ο Nelson Textbook of Pediatric 18th Edition, chapter 381
Editor's Notes
Continuous ossilation,E>I coz airway nlly dilate during I,,absence in severe cond:--therefore poor guide to severity
Airway narrowing start fm inflamm;of bronchus/bronchiolesο accumula ;of cells(N,L,E)ο congestion/oedemaο narrowing of wall of bronch,hypertrophy of s/m ,cell produceβmucous,plug formation
Older age- Pul parasitic infestation,Hypersensitivitypneumonitis,T.B,Immunedef,Pciliarydyskinesia
Dry& moist =pβia,Nocturnal = asthma
Evidence of poor wt gain suggests Immune def,CF and GOR
Chronic inflamm;is precipitated by E and G .Bronchoconstriction is strongly linked to airway hyper-responsiveness to *-irritentexposure,cold/dry air ..etc..Inflamm mediators β E,Cytokines,chemokines, NK ,mast cells(proinflamm cells)ο inflamm process
LFT=spirogram(FEV1,FVC,..)PEF,Flow-volume-loopFEV1/FVC =0.8(80%) useful in determin:ofobst and restrict d/sPEFR morning /evening variation >20% is consistent with asthma,morning dip is s/- of (worsening)uncontrolled asthma
Spirometric findings
DX,Severityass,Response to Tx, Compliance,PEFR diary
Attend school regularly,can participate in sport,sleep well without disturbance